The Effect of Guava on the Improvement of Lipid Profile in Hypercholesterolemic Rats

Abstract

Red guava is a fruit species with high vitamin C content and the highest fibers, in particular, soluble fiber (pectin) among tropical fruits and cereals. The soluble fiber is hypocholesterolemic in the body. Therefore, it has the potential to reduce cholesterol content. This study aimed to assess the potential of red guava in reducing cholesterol content in hypocholesterolemic rats. This study applied a pure experiment using a randomized pretestposttest group design on hypocholesterolemic Sprague Dawley rats. The rats were fed with 0.72 g of red guava and pectin supplement as a comparison. The total cholesterol content, LDL, HDL and triglyceride were measured by CHOD-PAP and GPO-PAP methods. Data analysis used t-test and ANOVA with significance rate of 0.05. Red guava intake to the hypocholesterolemic rats significantly reduced the contents of: total cholesterol to 57.8 mg/dL (32%), LDL to 25.5 mg/dL (43%), triglyceride to 19.7 mg/dL (18%). Conversely, it significantly increased HDL content to 10.6 mg/dL (18%). The red guava has proven to give hypocholesterolemic effect by reducing the total cholesterol LDL and triglyceride; Conversely, it significantly increased HDL.

Tropical Fruits and Their Co-Products as Bioactive Compounds and Their Health Effects: A Review

“…In its composition, it is possible to find several bioactive compounds These bioactive nutrients play significant roles in several health problems related to lifestyle diseases, such as diabetes (type 2), cardiovascular disease, several cancer types and obesity. As regards the hypocholesterolemic properties of guava, Maryanto and Marsono, [140] carried out a study to assess the potential of red guava in reducing cholesterol content in hyper-cholesterolemic rats. They found that red guava intake significantly reduced the contents of total cholesterol (32%), low-density lipoprotein cholesterol (43%), and triglyceride (18%).…”

The Effect of Banana Pseudostem Flour and Food Bar of Edible Canna Substituted with Banana Pseudostem Flour on Lipid Profile of Hypercholesterolemia Mice

“…This condition reinforced the suspect that EBP J30 flour and food bar could reduce the risk of atherosclerosis. The decrease in AIP value indicated the decreased levels of pro-atherogenic lipoproteins (triglycerides and LDL) and the increased anti-atherogenic (HDL) [35].…”

A non‐conventional approach for obtaining phenolic antioxidants from red guava (Psidium guajavaL.) by‐products

“…Guava ( Psidium guajava L.) is popular in tropical countries, being consumed fresh or processed into juices, frozen pulp, jams, and pie fillings. Besides its commercial value, it has been reported that this fruit present health‐promoting effects such as the mitigation of oxidative stress‐induced damage to human dermal fibroblasts (Alvarez‐Suarez et al, 2018), cytotoxicity against human breast adenocarcinoma cells (Dos Santos et al, 2018), and reduction of LDL cholesterol in rats (Maryanto & Marsono, 2019).…”