This study investigated the effects of attitudes toward patient safety, safety motivation, and nursing professionalism on patient safety performance confidence among nursing students. One hundred sixty-eight nursing students were surveyed between December 11 and 20, 2023, and the collected data were analyzed using the SPSS 25.0 program. Independent t-tests, one-way ANOVA, Pearson's correlation coefficients, and multiple regression analysis were employed for data analysis. The results revealed a significant correlation between patient safety performance confidence and attitude (r = 0.412, p <0.001), safety motivation (r = 0.550, p <0.001), and nursing professionalism (r = 0.585, p <0.001). Attitude also showed significant correlations with safety motivation (r = 0.307, p <0.001) and nursing professionalism (r = 0.384, p <0.001), as well as patient safety performance confidence (r = 0.412, p <0.001). Safety motivation significantly correlated with nursing professionalism (r = 0.317, p <0.001). The study identified nursing professionalism and safety motivation as factors influencing nursing students' confidence in patient safety performance (F = 56.04, p <0.001), with the model explaining 49.6% of the variance. Consequently, to enhance nursing students' confidence in patient safety performance, it is recommended that diverse safety management programs be implemented in nursing education and practice. These programs emphasize the importance of patient safety, foster positive nursing professionalism, and promote adherence to safety protocols during clinical practice.