The effect of hemodynamic changes induced by propofol induction on cerebral oxygenation in young and elderly patients

Hung, Ying; Huang, Chengwei; Kuok, Chi Hang; Chen, Chien-Chuan; Hsu, Yung-Wei

doi:10.1016/j.jclinane.2004.09.005

Cited by 9 publications

(10 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…After 3 min, FTOE and TOI returned to baseline, suggesting a better coupling between OD and consumption, despite the sustained decrease in MABP which seemed to have no further influence at that moment. In concordance with our findings, Hung et al [14] found a lower regional cerebral oxygen saturation (rSO 2 ) after propofol induction in young and elderly patients and suggest that this was induced by hypotension. Despite a decrease in MABP of 30% up to 5 min after administration, they saw a quick return to baseline of rSO 2 , suggesting an increase in fractional oxygen extraction with propofol administration.…”

Section: Discussionsupporting

confidence: 93%

“…This propofolinduced decrease in MABP is most likely the result of vasodilatation. Transient hypotension with propofol administration has been reported in many studies in adults and children [3,[14][15][16][17] . In neonates, however, only three studies report about the effect of propofol on MABP: Ghanta et al [4] found a slight, nonsignificant increase in MABP during propofol (2.5 mg kg -1 ) sedation for semielective intubation.…”

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Cerebral and Systemic Hemodynamic Effects of Intravenous Bolus Administration of Propofol in Neonates

Vanderhaegen¹,

Naulaers²,

Huffel³

et al. 2009

Neonatology

View full text Add to dashboard Cite

Objectives: To assess variability of systemic hemodynamics and its covariates following bolus propofol administration in (pre)term neonates, and to analyze the effect of propofol on cerebral tissue oxygenation index (TOI) and fractional tissue oxygen extraction measured by near-infrared spectroscopy. Methods: In (pre)term neonates, we recorded mean arterial blood pressure (MABP), saturation (SaO₂), heart rate (HR) and TOI from 5 min before up to 60 min after intravenous bolus propofol (3 mg kg^–1) administration during elective chest tube removal. Covariate analysis included postmenstrual age (PMA ≤ or >37 weeks), postnatal age (PNA ≤ or >10 days), comedication (fentanyl +/– midazolam) and congenital cardiopathy (yes/no). Fractional tissue oxygen extraction was calculated as (SaO₂ – TOI)/SaO₂. Results: Twenty recordings in 19 neonates were assessed. Following propofol administration, an abrupt, minor decrease in HR and SaO₂ was seen with fast recovery, while MABP decreased up to 1 h. TOI decreased during the first 3 min, reflecting an imbalance between cerebral oxygen delivery and demand. Despite sustained decrease in MABP, TOI then returned to baseline, suggesting a better balance between oxygen delivery and demand. PNA ≤10 days, comedication and absence of cardiopathy were associated with more subtle decreases in cerebral oxygenation and faster recovery. Conclusions: Propofol-induced decrease in HR, SaO₂ and cerebral oxygenation is short lasting while a decrease in MABP is observed up to 60 min. The variability in the effects of propofol is influenced by PNA, comedication or cardiopathy. Near-infrared spectroscopy can be used to assess hemodynamic effects of hypnotics on the cerebral oxygenation.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 96%

Cerebral and Systemic Hemodynamic Effects of Intravenous Bolus Administration of Propofol in Neonates

Vanderhaegen¹,

Naulaers²,

Huffel³

et al. 2009

Neonatology

View full text Add to dashboard Cite

show abstract

“…Therefore, a decrease in MABP is observed up to one hour after administration of propofol in neonates [8]. Premedicating neonates with propofol generally causes a modest and short-lasting decrease in HR, SaO 2 , and rScO 2 , as opposed to the longer-lasting and more pronounced decrease in MABP [8], [11,16,17]. In addition, the discontinuity pattern of the EEG is also influenced by propofol, which induces a reversible state of diminished responsiveness behaviorally similar to quiet (nonrapid eye movement (NREM)) sleep [18].…”

Section: Introductionmentioning

confidence: 99%

Using Graph Theory to Assess the Interaction between Cerebral Function, Brain Hemodynamics, and Systemic Variables in Premature Infants

et al. 2018

View full text Add to dashboard Cite

Graphs can be used to describe a great variety of real-world situations and have therefore been used extensively in different fields. In the present analysis, we use graphs to study the interaction between cerebral function, brain hemodynamics, and systemic variables in premature neonates. We used data from a propofol dose-finding and pharmacodynamics study as a model in order to evaluate the performance of the graph measures to monitor signal interactions. Concomitant measurements of heart rate, mean arterial blood pressure, arterial oxygen saturation, regional cerebral oxygen saturation-measured by means of near-infrared spectroscopy-and electroencephalography were performed in 22 neonates undergoing INSURE (intubation, surfactant administration, and extubation). The graphs used to study the interaction between these signal modalities were constructed using the RBF kernel. Results indicate that propofol induces a decrease in the signal interaction up to 90 minutes after propofol administration, which is consistent with clinical observations published previously. The clinical recovery phase is mainly determined by the EEG dynamics, which were observed to recover much slower compared to the other modalities. In addition, we found a more pronounced loss in cerebral-systemic interactions with increasing propofol dose.

show abstract

“…The decrease in MAP during anaesthesia induction with propofol caused minimal changes in the regional oxygen saturation in young and elderly patients, and the changes were related to those in MAP [22].…”

Section: Tissue Oxygenation and Oxygen Supply (Hb)mentioning

confidence: 85%

Management of physiological variables in neuroanaesthesia: maintaining homeostasis during intracranial surgery

Randell

Niskanen²

2006

Current Opinion in Anaesthesiology

View full text Add to dashboard Cite

show abstract

The effect of hemodynamic changes induced by propofol induction on cerebral oxygenation in young and elderly patients

Cited by 9 publications

References 24 publications

Cerebral and Systemic Hemodynamic Effects of Intravenous Bolus Administration of Propofol in Neonates

Cerebral and Systemic Hemodynamic Effects of Intravenous Bolus Administration of Propofol in Neonates

Using Graph Theory to Assess the Interaction between Cerebral Function, Brain Hemodynamics, and Systemic Variables in Premature Infants

Management of physiological variables in neuroanaesthesia: maintaining homeostasis during intracranial surgery

Contact Info

Product

Resources

About