1996
DOI: 10.1006/bbrc.1996.0819
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The Effect of Hepatitis B Virus X Gene Expression on Response to Growth Inhibition by Transforming Growth Factor-β1

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Cited by 16 publications
(13 citation statements)
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“…Loss of sensitivity to TGF-bs has also been observed in the progression of carcinogenesis (Kiso et al, 1994;Markowitz et al, 1995;Inagaki et al, 1993;Wang et al, 1996;Park et al, 1994;Oshikawa et al, 1996;Knaus et al, 1996). It may be possible that negative control of Src kinase by TGF-bs is impaired in these tissues or cell lines, inducing Src up-regulation.…”
Section: Discussionmentioning
confidence: 98%
“…Loss of sensitivity to TGF-bs has also been observed in the progression of carcinogenesis (Kiso et al, 1994;Markowitz et al, 1995;Inagaki et al, 1993;Wang et al, 1996;Park et al, 1994;Oshikawa et al, 1996;Knaus et al, 1996). It may be possible that negative control of Src kinase by TGF-bs is impaired in these tissues or cell lines, inducing Src up-regulation.…”
Section: Discussionmentioning
confidence: 98%
“…5,10,25,26 The perturbation in the postreceptor signaling pathway has been suggested to be involved in TGF-␤ resistance in some transformed cells, whereas the mechanism has not yet been well examined. Recently, we have reported that TGF-␤ 1 induces degradation of activated Src tyrosine kinase in rat fibroblasts.…”
Section: Discussionmentioning
confidence: 99%
“…3 Some transformed cells, however, exhibit poor response to TGF-␤-induced growth inhibition, and this loss of negative regulation contributes to the uncontrolled proliferation of these cells. [4][5][6][7][8][9][10][11] Therefore, an enhanced understanding of the mechanisms underlying the insensitiveness to TGF-␤s greatly facilitates the development of effective strategies for preventing the progression of carcinogenesis.…”
mentioning
confidence: 99%
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