The effect of hydrazine derivatives of 3-formylchromones on angiogenic basic fibroblast growth factor and fibroblast growth factor receptor-1 in human melanoma cell line WM-115

Abstract

The hydrazine derivatives of benzopyrones remain an unexplored group of chemical compounds. This preliminary study investigates the influence of A-5, CH-3 and K-2 derivatives at concentrations of 1, 10, 100 nM and 1 μM on selected biochemical factors of a melanoma cell line WM-115, with regard to their potential angiogenic properties. The studied compounds were found to influence cell proliferation, as well as total protein, bFGF and FGFR1 concentration.

Synthesis, Spectroscopic Analysis and Assessment of the Biological Activity of New Hydrazine and Hydrazide Derivatives of 3-Formylchromone

“…Previous studies have confirmed the antiproliferative properties [ 12 , 31 ] and biochemical activity [ 32 , 33 ] of 3-formylchromone derivatives. Moreover, biological activity of copper (II) complexes of 3-formylchromone, was also described [ 21 ]; however, hydrazine and hydrazide derivatives of benzopyrones with fluorine substituents remain a poorly-analyzed group of compounds.…”

Cancer Stem Cells: «Emergency Service» for Tumors Under Generalized Cellular Stress

“…Ну и наконец, мы нашли подтверждения, пусть и крайне немногочисленные, тому, что ксенобиотики также способны индуцировать стволовость опухолевых клеток [113,114], а также активировать экспрессию 21 из 96 «генов стволовости» TAMRA+ клеток опухоли Кребс-2: Abca1 [115], Acpp [81], Aldh1a1 [42], Cp [116], Cyp7a1 [117], Fgfr1 [118], Gas6 [119], Gstm3 [120], Igf1 [121], Igf2 [122], Il10 [123,124], Mmp2 [125], Nrcam [126], Pde4d [127], Pdk4 [128], Per2 [129], Pf4 [130], Pon1 [131], Rragd [105], Serpinb2 [132], Wnt5a [133].…”