The effect of hydrogen-rich water on letrozole-induced polycystic ovary syndrome in rats

Makav, Mustafa; Kuru, Mushap; Aras, Şükran Yediel; Sarı, Ebru Karadağ; Bulut, Menekşe; Alwazeer, Duried

doi:10.1016/j.rbmo.2023.103332

Cited by 3 publications

(1 citation statement)

References 36 publications

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“…Furthermore, H 2 has decreased inflammation in the uterus [ 26 ]. It has been revealed that HRW decreased the malondialdehyde, cortisol, and testosterone in female rats with polycystic ovary syndrome [ 27 ]. Another report revealed that HRW alleviated epithelial degeneration and necrosis in muscle fibers of tissues in animal models [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

The effect of hydrogen-rich water consumption on premenstrual symptoms and quality of life: a randomized controlled trial

Aker,

Gönenç,

Çalişici

et al. 2024

BMC Women's Health

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Background Premenstrual syndrome (PMS) consists of psychiatric or somatic symptoms negatively affecting the daily life. PMS treatment can involve the use of complementary-alternative approaches. Hydrogen-rich water (HRW) has antioxidant and anti-inflammatory properties that may treat PMS. This study aimed to investigate the effect of drinking HRW on the severity of premenstrual symptoms and the quality of life of women who suffer from PMS. Methods This study is a randomized controlled trial. Participants were randomized into two groups (intervention group=33, control group=32) using the block randomization method. Participants were requested to consume 1500-2000 mL of HRW daily in the intervention group and drink water in the placebo group. Participants began drinking either HRW or placebo water from day 16 of their menstrual cycle until day 2 of the following cycle for three menstrual cycles. The research data were collected using a Demographic Information Form, Premenstrual Syndrome Scale (PMSS), and Short form of the World Health Organization Quality of Life Questionnaire (WHOQOL- BREF). Results The intervention group had significantly lower mean scores than the control group in both the first and second follow-ups on the PMSS (P<0.05). In the first follow-up, the intervention group had significantly higher mean scores in the Physical Health and Psychological domains of the WHOQOL-BREF compared to the control group (P<0.05). Group × time interaction was significant for PMSS (F = 10.54, P<0.001). Group × time interaction was insignificant for WHOQOL- BREF (P>0.05). Conclusions The consumption of HRW reduces the severity of premenstrual symptoms and improves individuals' quality of life in physical and psychological domains.

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Section: Discussionmentioning

confidence: 99%

The effect of hydrogen-rich water consumption on premenstrual symptoms and quality of life: a randomized controlled trial

Aker,

Gönenç,

Çalişici

et al. 2024

BMC Women's Health

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Combating oxidative stress and inflammation in gentamicin-induced nephrotoxicity using hydrogen-rich water

Cumaoglu,

Makav,

Dag

et al. 2024

Tissue and Cell

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The effect of letrozole on liver function and some biochemical parameters in rats

Dolanbay,

Makav,

Vural

et al. 2024

Journal of Advances in VetBio Science and Techniques

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Letrozole (LTZ), is an aromatase inhibitor, that has been widely used in a variety of diseases such as polycystic ovary syndrome, endometriosis, and breast cancer. LTZ is received via the oral route and metabolized in the liver. Therefore, LTZ may have toxic effects like other drugs metabolized in the liver. Based on this, our study aimed to investigate the effect of LTZ on liver function and biochemical parameters. For this purpose, 16 Wistar albino female rats were divided into two groups (n=8): Control and LTZ respectively. The rats in the letrozole group were administered with 2 mL/kg LTZ by oral gavage once a day for 21 days. The Control group received the vehicle once a day for 21 days. Blood samples were collected on the 22nd day of the experiment. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), lactate dehydrogenase (LDH), albumin (ALB), alkaline phosphatase (ALP), direct bilirubin and total bilirubin were measured. Biochemical analysis indicated that ALT, AST, LDH, ALP, and total bilirubin levels were significantly higher in the LTZ administrated group compared to the Control. ALB levels decreased in the LTZ group. In conclusion, it was determined that LTZ has toxic and detrimental effects on the liver. We suggested that long-term LTZ administrated patients should be under control against liver damage and may have liver supporting adjuvant therapies for robust liver functions.

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The effect of hydrogen-rich water on letrozole-induced polycystic ovary syndrome in rats

Cited by 3 publications

References 36 publications

The effect of hydrogen-rich water consumption on premenstrual symptoms and quality of life: a randomized controlled trial

The effect of hydrogen-rich water consumption on premenstrual symptoms and quality of life: a randomized controlled trial

Combating oxidative stress and inflammation in gentamicin-induced nephrotoxicity using hydrogen-rich water

The effect of letrozole on liver function and some biochemical parameters in rats

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