2011
DOI: 10.1016/j.biomaterials.2011.08.072
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The effect of hydrophilic chain length and iRGD on drug delivery from poly(ε-caprolactone)-poly(N-vinylpyrrolidone) nanoparticles

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Cited by 114 publications
(80 citation statements)
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“…This results in the generation of CRGDK/R, which dissociates from the integrins and binds to neuropilin-1 (NRP1), thereby activating an endocytic bulk transport pathway through the tumor tissue (8)(9)(10)(11). The increased tumor delivery of iRGDconjugated payloads has been shown in different experimental tumor models by other independent studies (12,13) and translates into a higher therapeutic efficacy (4,5).…”
Section: Introductionmentioning
confidence: 96%
“…This results in the generation of CRGDK/R, which dissociates from the integrins and binds to neuropilin-1 (NRP1), thereby activating an endocytic bulk transport pathway through the tumor tissue (8)(9)(10)(11). The increased tumor delivery of iRGDconjugated payloads has been shown in different experimental tumor models by other independent studies (12,13) and translates into a higher therapeutic efficacy (4,5).…”
Section: Introductionmentioning
confidence: 96%
“…Thus, when nanoparticles, nanogels, or anticancer agents are modified with iRGD, their tissue-penetrating and tumor-targeting properties can be improved. 11,[13][14][15][16][17] Additionally, when iRGD was coadministrated with drugs or a systemic injection drug delivery system, antitumor activities were also improved. 12 In the past, liposomes have been used as drug carriers to improve the pharmacokinetics of drugs, resulting in reduced toxicities and enhanced therapeutic efficacies.…”
Section: Introductionmentioning
confidence: 99%
“…175 The mechanism of the iRGD includes three steps: the RGD motif targets αv integrins on tumor endothelium, then iRGD undergoes a proteolytic cleavage acquiring the ability to bind to neurophilin-1 to achieve tissue penetration. 175 Linear iRGD (CRGDRCPDC) was conjugated to poly(ε-caprolactone)-poly(N-vinylpyrrolidone) (PCL-PVP) NPs by Zhu et al 176 The result of cytotoxicity and uptake investigation indicated that the iRGD-conjugated PCL-PVP NPs possessed higher cytotoxicity than the unconjugated NPs against murine hepatic H22 cell at 12 and 24 h after incubation. Through in vivo studies on H22-transplanted solid tumor model, they further demonstrated the superior antitumor efficacy of iRGD-conjugated NPs over the unconjugated counterparts.…”
mentioning
confidence: 99%