The effect of hydroxyapatite addition on the mechanical properties of polyvinyl alcohol/chitosan biomaterials for bone scaffolds application

Abstract

The total antioxidant capacity and fluorescence imaging of selected plant leaves commonly consumed in Brunei Darussalam AIP Conference Proceedings 1933, 020001 (2018) Abstract. The increasing number of bone fracture incident in Indonesia from year to year needs an urgent problem solving of the limited bone substitute which can meet the necessary criteria for that purpose. Motivated by this, therefore, the current study is focusing on the optimization of material properties used as bone scaffold. A biomaterial of polyvinyl alcohol (PVA)/chitosanhydroxyapatite (HA) composite was successfully made by wet chemistry method, followed by freeze thawing and freeze drying. For comparison purposes, the percentage of HA has been varied from 0, 25 and 40 % (wt/v). The resulting composites were characterized by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscope (SEM), compressive test, and swelling behavior. The results showed that the addition of HA up to 40% (wt/v) has yielded a porous structure with an average pore size of 42.39 μm. In addition, the compressive modulus was enhanced from 14 MPa for 0% HA to 143, and 191 MPa for composites with the addition of HA from 25 to 40% (wt/v). The addition of HA has also reduced the swelling ratio from 296% for the sample without HA to 85 and 78 % for sample with addition of HA from 25 to 40 (wt/v), respectively. The obtained results show that PVA/chitosan-HA in this study is potential to be used as scaffold in bone tissue engineering.

Novel Hybrid Composites Based on PVA/SeTiO2 Nanoparticles and Natural Hydroxyapatite for Orthopedic Applications: Correlations between Structural, Morphological and Biocompatibility Properties

“…In order to overcome the disadvantage of poor adherence to PVA, hydrogels with both bioactive and biocompatible components were developed by adding HA particles as a second reinforcing phase. The idea is not new, with several studies being reported in the literature [40,44,46,47,52]. For example, Wu et al [52] have incorporated HA into PVA hydrogel and developed a bioactive composite suitable for orthopedic applications such as artificial cartilage, studying the correlation between the immersion time in SBF (simulated body fluid) and the mechanical properties of these composites.…”

“…The observed features indicate that the presence of HA in PVA composites strongly influences the sample morphology, producing a fibrous and porous structure, which may provide advantages in using this material as soft tissue replacement, with interconnected small pores for micro-vascularization. At the same time, the presence of HA inside the "honeycomb" may have an important role in the adhesion ability of the osteogenic and chondrogenic precursor cells, supporting their differentiation, as well as the proliferation [44,45].…”

Enhancing surface morphology, mechanical, and wettability properties of PVA/chitosan/HAp nanofiber scaffold through dielectric barrier discharge plasma treatment

“…FTIR analysis revealed overlapping stretching vibrations corresponding to CO and NH functional groups, confirming the presence of chitosan within the nanofiber matrix. Meanwhile, the characteristic PO 4 3− stretching group at wave number 1020.84-1041.56 cm −1 confirmed the presence of Hap [47], while the PO 4 3− bending group was observed at 588.28 cm −1 and the CO 3…”

“…It is energy-efficient and environmentally friendly, making it a particularly attractive option for achieving this goal [7]. Composite scaffolds have better performance than monomaterial scaffolds [8,9]. Commonly used bone scaffold fabrication methods include gas foaming [10], solvent-casting [11], thermal phase separation [12], rapid prototyping [13], freeze-drying [14], and electrospinning [15].…”

Constructed microbubble porous scaffolds of polyvinyl alcohol for subchondral bone formation for osteoarthritis surgery

“…This demonstrates the ability of the scaffolds to swell and allow their pores to expand which facilitates the attachment and penetration of the bone cells into the scaffolds to grow in a 3D direction. On the other hand, a scaffold that swells too much can damage the frame structure and hinder cell attachment and growth [35]. Thus, the scaffolds must maintain a certain hydration state and keep a moderate intensity force.…”