The effect of hydroxyapatite coating on the fixation of hip prostheses

Huracek, J.; Spirig, P

doi:10.1007/bf00572908

Cited by 31 publications

(9 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Long-term in vivo studies have demonstrated that mechanical failure occurs at the metal/HAP interface rather than at the bone/HAP interface. 13 Numerous investigators have therefore examined better ways of depositing thin calcium phosphate coatings. Techniques that have been developed include CPP deposition by storage in simulated body fluid with or without alkaline pretreatment, 7,14 sol-gel processes, 5,15,16 and electrochemical methods.…”

Section: Introductionmentioning

confidence: 99%

Electrochemically assisted deposition of thin calcium phosphate coatings at near‐physiological pH and temperature

Rößler

Sewing

Stölzel

et al. 2003

J Biomedical Materials Res

121

View full text Add to dashboard Cite

An electrochemical method for the deposition of calcium phosphate phases on titanium surfaces using the galvanostatic mode is presented. Deposition was performed in a (Ca(2+) / H(x)PO(4) ((3-x)-))-containing electrolyte near physiological conditions with regard to pH (6.4) and temperature (36 degrees C). Cathodic alkalization leads first to the formation of a thin homogeneous layer that shows a nanoscale surface topography of alternating wall-like elevations and channels. It is thought that these channels in the calcium phosphate prelayer are formed as pathways for hydroxyl ions and hydrogen. Upon this layer, spheres of amorphous calcium phosphate (ACP) are formed as indicated by Fourier transform infrared spectroscopy (FTIR) and transmission electron microscopy. According to transmission electron microscopy images, these spheres consist of small clusters of calcium phosphate (approximately 30 nm) and can grow up to 300 nm in diameter. Characteristic for this ACP is a high water content as seen by FTIR. As a function of current density, the ACP is then transformed into crystalline hydroxyapatite (HAP), which was identified using FTIR and X-ray diffraction. The morphology of the HAP crystals can be described as needles with dimensions of <500-nm length and <60-nm width. By choice of different electrochemical parameters, a homogeneous coating of either ACP, HAP, or the intermediate phase can be achieved, as shown in a kinetic phase diagram, thus allowing the formation of coatings with different properties in solubility and morphology.

show abstract

Section: Introductionmentioning

confidence: 99%

Electrochemically assisted deposition of thin calcium phosphate coatings at near‐physiological pH and temperature

Rößler

Sewing

Stölzel

et al. 2003

J Biomedical Materials Res

121

View full text Add to dashboard Cite

show abstract

“…Biovidros, alumina, beta fosfato tricálcico (β-TCP), octafosfato de cálcio (OCP) e a hidroxiapatita (HAp) são exemplos de materiais cerâmicos utilizados nas pesquisas com biomateriais, sendo bastante usados na área médica-odontológica [8]. A HAp é um fosfato de cálcio largamente utilizado como biomaterial em aplicações médicas, tais como revestimento de próteses, substituições de pequenas partes ósseas e sistema de entrega de drogas [9,10]. Essas aplicações são permitidas devido à HAp ser um componente natural do organismo, estando presentes em dentes e ossos com uma porcentagem de 30 a 70% em massa total destes tecidos.…”

Section: Introductionunclassified

Desenvolvimento de biomaterial composto por hidroxiapatita e clorexidina para aplicação na cavidade oral

et al. 2019

View full text Add to dashboard Cite

ResumoA hidroxiapatita (HAp) está presente no organismo humano nos tecidos ósseos e dentários, em que do total da massa de cada tecido 30 a 70% correspondem a HAp, podendo ser aplicada como revestimentos de próteses ou até substituição de pequenas partes ósseas. Assim, o objetivo foi sintetizar HAp por precipitação, incorporar clorexidina (CHX) e avaliar as propriedades microbianas. A caracterização foi realizada por DRX, FTIR, TG/DTG, MET e MEV. A CHX foi incorporada à HAp por adsorção, variando a quantidade incorporada. O difratograma apresentou picos em 25,9º, 31,5°, 32,2º e 32,7º (2θ) referentes aos planos (002), (211), (112) e (300) da HAp. O espectro de FTIR mostrou banda em 1050 cm -1 correspondente à deformação dos grupos fosfatos e deformações de grupos CH 2 em 1485 e 1445 cm -1 da clorexidina, que apresentou morfologia porosa e cilíndrica. O biomaterial apresentou excelentes propriedades antimicrobianas frente a Streptococcus mutans, Staphylococcus aureus e Escherichia coli. Palavras-chave: hidroxiapatita, clorexidina, atividade antimicrobiana. AbstractHydroxyapatite (HAp) is present in the human body in bone and dental tissues, which of the total mass of each tissue 30 to 70% correspond to HAp, and can be applied as coatings of prostheses or replacement of small bone parts. Thus, the objective was to synthesize HAp by precipitation, to incorporate chlorhexidine (CHX) and to evaluate the microbial properties. The characterization was performed by XRD, FTIR, TG/DTG, TEM and SEM. CHX was incorporated into the HAp by adsorption, varying the amount incorporated. The XRD pattern showed peaks at 25.9º, 31.5º, 32.2ºand 32.7º (2θ) for planes (002), (211), (112) and (300) of HAp. The FTIR spectrum showed band at 1050 cm -1 corresponding to the deformation of the phosphate groups and deformations of CH 2 groups at 1485 and 1445 cm -1 of chlorhexidine, which presented porous and cylindrical morphology. The biomaterial showed excellent antimicrobial properties against Streptococcus mutans, Staphylococcus aureus and Escherichia coli.

show abstract

“…HA is often used as a bone filler, and as a coating for metal implants to improve fixation of the implant to bone tissue [6]. Though HA is promising for clinical use [7,8], some reports have suggested that HA coatings can produce nanoparticulate debris, causing toxicity and inflammation in the body [9,10]. In pregnant mice it has been shown that NPs cross the placenta, accumulate in the fetus [11], restrict blood flow, reduce placenta size, and cause fetal growth restriction, eventually causing death.…”

Section: Introductionmentioning

confidence: 99%

The Influence of Hydroxyapatite Nanoparticle Morphology on Embryonic Development in a Zebrafish Exposure Model

Pujari-Palmer

Ott

2017

Nanomaterials

View full text Add to dashboard Cite

Nanomaterials are used in many different industries such as cosmetics, food, clothing, and electronics. There is increasing concern that exposure to nanoparticles (NPs) during pregnancy can adversely affect fetal development. It is well known that the size, charge, and chemistry of a nanoparticle can modulate embryological development. The role that particle morphology plays on early development, however, is still widely unknown. The present study aims to investigate the effect of hydroxyapatite nanoparticle (HANP) morphology on embryological development in a zebrafish exposure model. Four distinct HANP morphologies (dots, long rods, sheets, and fibers) were fabricated and characterized. Zebrafish embryos were exposed to HANPs (0–100 mg/L), and viability and developmental deformities were evaluated for up to 5 days post-fertilization (dpf). Malformations such as pericardial edema and axial curvature were apparent in embryos as early as 1 dpf, following exposure to the dot and fiber particles, and developed in embryos by 3 dpf in the sheet and long rod particle groups. Minimal death was observed in response to dot, long rod, and sheet particles (≤25%), while fiber particles induced overwhelming toxicity (≤60%) after 1 dpf, and complete toxicity during all subsequent time points. Collectively, these results suggest that nanoparticle morphology can significantly impact embryological development and should be a required consideration when designing nanomaterials for commercial use.

show abstract

The effect of hydroxyapatite coating on the fixation of hip prostheses

Cited by 31 publications

References 23 publications

Electrochemically assisted deposition of thin calcium phosphate coatings at near‐physiological pH and temperature

Electrochemically assisted deposition of thin calcium phosphate coatings at near‐physiological pH and temperature

Desenvolvimento de biomaterial composto por hidroxiapatita e clorexidina para aplicação na cavidade oral

The Influence of Hydroxyapatite Nanoparticle Morphology on Embryonic Development in a Zebrafish Exposure Model

Contact Info

Product

Resources

About