The effect of hydroxypropylmethylcellulose on water penetration into a matrix system

Wan, Lucy S.C.; Heng, Paul Wan Sia; Wong, L. F.

doi:10.1016/0378-5173(91)90033-k

Cited by 65 publications

(22 citation statements)

References 7 publications

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“…Swelling is the result of the gradual imbibing of water to form an increasingly hydrated gel layer which is the diffusional path length across which the pharmaceutical active is transported via mechanisms of diffusion and gel layer dissolution (Wan et al, 1991;60 Panomsuket al, 1996). For polysaccharide matrices, this process has been shown to follow square root of time kinetics (Munday and Cox, 2000;Kavanagh and Corrigan, 2004).…”

Section: Introductionmentioning

confidence: 99%

Starch-free grewia gum matrices: Compaction, swelling, erosion and drug release behaviour

Nep

Asare-Addo

Ghori

et al. 2015

International Journal of Pharmaceutics

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Section: Introductionmentioning

confidence: 99%

Starch-free grewia gum matrices: Compaction, swelling, erosion and drug release behaviour

Nep

Asare-Addo

Ghori

et al. 2015

International Journal of Pharmaceutics

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“…8a). This could be attributed to the fact that the pores of high molecular weight HPMC probably block up quickly and inhibit further liquid uptake, decreasing dilution and erosion and subsequently resulting in slower drug diffusion and release rates [21,37,38]. For the films prepared with addition of PVP in the formulation, the drug release profiles did not change significantly compared with those without PVP (Fig.…”

Section: Redispersion Of Drug Particles and In Vitro Drug Release Promentioning

confidence: 65%

Synthesis and immobilization of micro-scale drug particles in cellulosic films

Meng

Yang²,

Keyvan

et al. 2011

Colloids and Surfaces B: Biointerfaces

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“…Due to the high water affinity of the polymer, these forces are likely to be preferred over polymer-polymer interactions. Therefore the forces holding the polymer segments together is reduced and the polymer chains can swell (10). Water diffuses into the matrix and when its concentration reaches a threshold value, the polymer swells and a gel layer is formed at the beginning to unfold and gradually become solvated.…”

Section: Polyox ® Wsr 303mentioning

confidence: 99%

Preparation and In-vivo Pharmacokinetic Study of a Novel Extended Release Compression Coated Tablets of Fenoterol Hydrobromide

Elshafeey

Sami

2008

AAPS PharmSciTech

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Abstract. The aim of this study was to formulate extended release compression coated core tablets of fenoterol hydrobromide, a selective β 2 adrenergic receptor agonist, in an attempt to prevent nocturnal asthma. Two hydrophilic polymers viz Kollidon ® SR, Polyox ® WSR 303 and a hydrophobic one (Precirol ® ATO5) were employed. Compression coated tablets were formulated by preparing a core tablet containing 7.5 mg drug and various amounts of polymer and Emcompress ® then compressed coated with the same polymeric materials. For comparison purpose different matrix tablets were also prepared employing the same polymers. In-vitro release studies were carried out at different pH (1.2 and 6.8). Pharmacokinetics of extended release tablets as well as commercially available immediate release tablets (Berotec ® ) were studied after oral administration to beagle dogs using a new developed LC-MS/ MS method with a lower limit of quantification of 1 ng/ml. Fenoterol release from compression coated tablets was significantly lower than matrix tablets. The mechanism of release was changed with the nature and content of polymer. The release pattern of drug from F16 containing 40 mg Kollidon ® SR divided in the core tablet (15 mg) and the rest in the compressed coat (25 mg) showed a typical zero order release kinetic that could extend drug release >10 h and reasonable time for 75% to be released (t 75 ) (8.92 h). When compared to immediate release Berotec ® tablet the MRT was significantly extended from 7.03±0.76 to 10.93±1.25 h (P<0.001) and HVD t 50%Cmax was also significantly extended from 2.71±0.68 to 6.81±0.67 h with expected prevention of nocturnal asthma.

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The effect of hydroxypropylmethylcellulose on water penetration into a matrix system

Cited by 65 publications

References 7 publications

Starch-free grewia gum matrices: Compaction, swelling, erosion and drug release behaviour

Starch-free grewia gum matrices: Compaction, swelling, erosion and drug release behaviour

Synthesis and immobilization of micro-scale drug particles in cellulosic films

Preparation and In-vivo Pharmacokinetic Study of a Novel Extended Release Compression Coated Tablets of Fenoterol Hydrobromide

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