The effect of hyperbilirubinemia on motor repertoire of infants between 3 and 5 months of age

Kahraman, Aysu; Alkan, Halil; Çelik, Hasan Tolga; Mutlu, Akmer

doi:10.1007/s00431-021-04162-4

Cited by 9 publications

(9 citation statements)

References 21 publications

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“…The delivered treatments to reduce hyperbilirubinemia were phototherapy (Agrawal et al, 1998; Can et al, 2015; Y. Chen & Kang, 1995; Deorari et al, 1994; Grimmer et al, 1999; Hokkanen et al, 2014; Hung, 1989; Kahraman et al, 2021; Lunsing et al, 2013; Sabatino et al, 1996; Soorani‐Lunsing et al, 2001; Wong et al, 2006) ( n = 12) and blood transfusion ( n = 14) (Agrawal et al, 1998; Bengtsson & Verneholt, 1974; Y. Chen & Kang, 1995; Deorari et al, 1994; Grimmer et al, 1999; Gupta et al, 1990; Hokkanen et al, 2014; Holmes et al, 1968; Hung, 1989; Kahraman et al, 2021; Özmert et al, 1996; Rubin et al, 1979; Sabatino et al, 1996; Wong et al, 2006), which are the two interventions recommended by clinical practice guidelines for the resolution of pathologically increased bilirubin (Table A6).…”

Section: Resultsmentioning

confidence: 99%

“…Finally, four studies conducted a general physical evaluation (Bengtsson & Verneholt, 1974; Holmes et al, 1968; Özmert et al, 1996; Wong et al, 2006) as a complementary tool to those described above. In summary, eight studies found neurological alterations, among which the main pathologies were as follows: choreoathetoid cerebral palsy, diagnosed with early detection tools or clinical signs before the age of 2 years (Bengtsson & Verneholt, 1974; Besli et al, 2020; Kahraman et al, 2021; Özmert et al, 1996); ADHD, diagnosed through a retrospective study where subjects were questioned at the age of 30 years (Hokkanen et al, 2014); and MND, diagnosed by clinical signs and neurological evaluations at the age of 1 year (Grimmer et al, 1999; Lunsing et al, 2013; Özmert et al, 1996; Soorani‐Lunsing et al, 2001). Moreover, all of these studies reported neurological disorders during the first year of life, such as alterations in muscle tone (hypotonia).…”

Section: Resultsmentioning

confidence: 99%

“…Eighteen studies (Agrawal et al, 1998;Bengtsson & Verneholt, 1974;Besli et al, 2020;Y. Chen & Kang, 1995;de Almeida et al, 2002;Deorari et al, 1994;Grimmer et al, 1999;Gupta et al, 1990;Hokkanen et al, 2014;Holmes et al, 1968;Hung, 1989;Kahraman et al, 2021;Lunsing et al, 2013;Özmert et al, 1996;Rubin et al, 1979;Sabatino et al, 1996;Soorani-Lunsing et al, 2001;Wong et al, 2006) analysed the effect of neonatal hyperbilirubinemia in fullterm newborns and one study (Can et al, 2015) in preterm infants. An overall sample of 2210 subjects was evaluated of which 2023 were born at term and 187 were premature.…”

Section: Systematic Reviewmentioning

confidence: 99%

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Neonatal hyperbilirubinemia and repercussions on neurodevelopment: A systematic review

Merino‐Andrés,

Pérez‐Nombela,

Álvarez‐Bueno

et al. 2023

Child

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BackgroundAccumulation of bilirubin above normal levels is considered a neurological risk factor for both premature and full‐term newborns. This systematic review aimed to determine the effect of neonatal hyperbilirubinemia on neurodevelopment in preterm and full‐term newborns.MethodsPubMed, EMBASE, Cochrane Library, CINAHL, PsycINFO, Scopus and Lilacs databases were searched for articles published until 1 June 2022. The quality of cohort and case–control studies was assessed with the Newcastle–Ottawa Scale, and the MINCir scale was used to evaluate the methodological quality of therapy studies or the therapeutic procedures. Premature neonates without neurological conditions and those born at term with hyperbilirubinemia as the sole risk factor were included. Studies reporting one or more neurodevelopmental outcomes were included with an inter‐group comparison of a hyperbilirubinemia group versus a non‐hyperbilirubinemia or non‐pathological hyperbilirubinemia group. The main outcomes were auditory function, visual function, cognitive function, motor function, behavior, global development and neurological risk.ResultsThe search identified 951 studies, 19 of which (n = 2210 newborns) were finally included. Fifteen of the cohort and case–control studies presented low risk of bias, and six studies showed high methodological quality. Within the preterm population, hyperbilirubinemia as the sole risk factor was not shown to affect neurodevelopment. Auditory, neurological and motor development alterations were found in the population of full‐term newborns with hyperbilirubinemia, which were more evident during the first year of life.ConclusionsElevated bilirubin levels may be a trigger for the onset of neurodevelopmental disorders in full‐term infants during the first year of life. More studies are warranted in the preterm population with hyperbilirubinemia to draw conclusions about its impact on their neurodevelopment.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Systematic Reviewmentioning

confidence: 99%

See 1 more Smart Citation

Neonatal hyperbilirubinemia and repercussions on neurodevelopment: A systematic review

Merino‐Andrés,

Pérez‐Nombela,

Álvarez‐Bueno

et al. 2023

Child

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“…The GMA component of the MOS-R was scored by two advanced-certified raters and any disagreements were settled through review between three raters. Reliability for the MOS-R has previously been reported to be high with intraclass correlation coefficients of 0.86–0.98 [ 26 , 27 , 28 , 29 ]. The MOS-R consists of five subsections: (i) fidgety movements, which is assigned a score of 1, 4 or 12 for absent/sporadic, abnormal or normal movements respectively; (ii) observed movement patterns, that tallies the number of typical and atypical observed postures and assigns a score of 1 for more atypical movements, 2 for equal number of atypical and typical movements, and 4 for more typical movements/postures; (iii) the age-adequate movement repertoire scores 1 (absent), 2 (reduced), or 4 (present) which is determined by a checklist of movements that are expected to be observed depending on the age of assessments: at 9–11, 12–13, 14–15, and over 16 weeks’ CA; (iv) observed postural patterns, which follows a similar scoring concept to subsection (ii), but observes postural patterns rather than movement patterns; (v) movement character, which describes an infant’s movements as either smooth and fluent (score 4), not smooth and fluent, but not cramped-synchronized (score 2), or cramped-synchronized (score 1).…”

Section: Methodsmentioning

confidence: 99%

Early Motor Repertoire of Very Preterm Infants and Relationships with 2-Year Neurodevelopment

Kwong

Boyd

Chatfield

et al. 2022

JCM

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The Motor Optimality Score, revised (MOS-R) is an extension of the Prechtl General Movements Assessment. This study aims to determine the relationship between MOS-R and 2-year neurodevelopmental outcomes in a cohort of 169 infants born very preterm (<31 weeks’ gestational age), and to examine the predictive validity of the MOS-R at 3–4 months’ corrected age (CA) above perinatal variables associated with poor outcomes, including Prechtl fidgety movements. Development at 2 years’ CA was assessed using Bayley Scales of Infant and Toddler Development, Third edition (Bayley-III) (motor/cognitive impairment: Bayley-III ≤ 85) and Neurological, Sensory, Motor, Developmental Assessment (NSMDA) (neurosensory motor impairment: NSMDA ≥ 12). Cerebral palsy (CP) was classified at 2 years as definite or clinical. The MOS-R was related to 2-year outcomes: Bayley-III motor (BMOS-R = 1.24 95% confidence interval (0.78, 1.70)), cognitive (BMOS-R = 0.91 (0.48, 1.35)), NSMDA scores (BMOS-R = −0.34 (−0.42, −0.25)), definite CP (odds ratio [OR] 0.67 (0.53, 0.86)), clinical CP (OR 0.74 (0.66, 0.83)) for each 1-point increase in MOS-R. MOS-R ≤ 23 predicted motor (sensitivity 78% (60–91%); specificity 63% (54–72%)) and neurosensory motor impairment (sensitivity 86% (64–97%); specificity 59% (51–68%)). The MOS-R is strongly related to CP and motor and cognitive delay at 2 years and is a good predictor of motor and neurosensory motor impairment.

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“…16 Existing prospective cohort studies of very low birthweight infants have found that higher motor optimality scores are associated with better motor function at 1 year 17 and with cognitive, language and motor development of very preterm infants at 2 years. 18 Recent studies have identified median MOS-R between 24 and 26 for infants born at term, [19][20][21][22][23] and a study investigating the difference in infants born EP with adverse outcomes found lower median MOS-R (17.5) compared with infants born EP with a normal outcome (median MOS- R 21). 24 To our knowledge, no studies have documented typical MOS-R scored from…”

Section: While Fidgety Movements Have Good Predictive Validitymentioning

confidence: 99%

Parent‐recorded videos of infant spontaneous movement: Comparisons at 3–4 months and relationships with 2‐year developmental outcomes in extremely preterm, extremely low birthweight and term‐born infants

Kwong

Doyle

Olsen

et al. 2022

Paediatric Perinatal Epid

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Background: Infants born extremely preterm (EP, <28-week gestational age) or extremely low birthweight (ELBW, <1000 g) are at risk of developmental delay and cerebral palsy (CP). The General Movements Assessment (GMA) and its extension, the Motor Optimality Score, revised (MOS-R) (assesses movement patterns and posture), may help to identify early delays.Objectives: To compare differences in the MOS-R scored from parent-recorded videos between infants born EP/ELBW and term-born infants, to determine relationships between the MOS-R and 2-year cognitive, language and motor outcomes and if any relationships differ between birth groups and the association of the GMA (fidgety) with CP.Methods: A geographical cohort (EP/ELBW and term-control infants) was assessed using the MOS-R inclusive of the GMA at 3-to 4-month corrected age (CA), and the Bayley Scales of Infant and Toddler Development, 3rd edition (Bayley-III) at 2-year CA. Differences in mean total MOS-R between groups, relationships between MOS-R and 2-year outcomes and relationships between GMA (fidgety) and CP in infants born EP/ELBW were estimated using linear/logistic regression.Results: Three hundred and twelve infants (147 EP/ELBW; 165 term) had complete MOS-R and Bayley-III assessments. Mean MOS-R was lower in infants born EP/ELBW than controls (mean difference −3.2, 95% confidence interval [CI] −4.2, −2.3). MOS-R was positively related to cognitive (β [regression coefficient] = 0.71, 95% CI 0.27, 1.15), language (β = 0.96, 95% CI 0.38, 1.54) and motor outcomes (β = .89, 95% CI 0.45, 1.34). There was little evidence for interaction effects between birth groups for any outcome. Absent/abnormal fidgety movements were related to CP in children born EP/ELBW (risk ratio 5.91, 95% CI 1.48, 23.7).Conclusions: Infants born EP/ELBW have lower MOS-R than infants born at term.

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The effect of hyperbilirubinemia on motor repertoire of infants between 3 and 5 months of age

Cited by 9 publications

References 21 publications

Neonatal hyperbilirubinemia and repercussions on neurodevelopment: A systematic review

Neonatal hyperbilirubinemia and repercussions on neurodevelopment: A systematic review

Early Motor Repertoire of Very Preterm Infants and Relationships with 2-Year Neurodevelopment

Parent‐recorded videos of infant spontaneous movement: Comparisons at 3–4 months and relationships with 2‐year developmental outcomes in extremely preterm, extremely low birthweight and term‐born infants

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