The Effect of Hyperventilation on “Excess Lactate” Production During Anaesthesia

Sykes, M.K.; Cooke, Pauline

doi:10.1093/bja/37.6.372

Cited by 17 publications

(3 citation statements)

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“…When inoccur during either active (voluntary) or passive dividual values were plotted, some of the pH hyperventilation while awake or during anesthesia values were below the band (Fig. 1) and some [27]. It has been postulated that the decrease of of the HC0 3 " values were above the band (Fig.…”

Section: Discussionmentioning

confidence: 97%

Normal pregnancy: A model of sustained respiratory alkalosis

Fadel¹,

Northrop²,

Misenhimer³

et al. 1979

Journal of Perinatal Medicine

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Section: Discussionmentioning

confidence: 97%

Normal pregnancy: A model of sustained respiratory alkalosis

Fadel¹,

Northrop²,

Misenhimer³

et al. 1979

Journal of Perinatal Medicine

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“…In our patient the elevation in blood lactate and pyruvate was due to hyperventilation. Although in Huckabee's experiments the lactate/pyruvate ratio in man or dog was not changed during hyperventilation (Huckabee 1958), excess lactate accumulation has been noted by most other investigators (Tobin 1964, Sykes and Cooke 1965, Eldridge and Salzer 1967, Zborowska-Sluis and Dossetor 1967, Zborowska-Sluis et al 1970). I n our patient also, hyperventilation was accompanied by an increase in the lactate/ pyruvate ratio.…”

Section: Discussionmentioning

confidence: 87%

Lactic Acidaemia Due to Hyperventilation in a Child with Severe Mental Retardation

Monnens

Willems

Kollée

et al. 1976

Develop Med Child Neuro

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SUMMARY A 16‐year‐old girl with severe mental retardation of unknown aetiology presented with increased blood content of lactate and pyruvate. It was demonstrated that the biochemical abnormalities were due to hyperventilation. RÉSUMÉ L'observation d'une fille de seize ans avec une rétardation mentale sévère est présenté. L'acide lactique et l'acide pyruvique étaient augmentées dans le sang. On a démontre que cette augmentation était causée par l'hyperventilation. ZUSAMMENFASSUNG Es wird ein 16‐jähriges, geistig sehr stark zuruckgebliebenes Mädchen beschrieben mit erhöhten Blutspiegel von Laktat und Pyruvat. Diese biochemische Abweichungen konnten einer Hyperventilierung zugeschrieben werden. RESUMEN Una muchacha de 16 años con retraso mental grave de origen desconocido apareció con un aumento de contenido en sangre de ácido lactico y piruvato. Se demostró que las anomalías eran debidas a una hiperventilación.

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“…Vasoconstriction resulting from hypocapnia may have been responsible by reducing the blood supply critically. Sykes and Cooke (1965) deliberately produced hypocapnia during anaesthesia and measured lactate and pyruvate levels before and after reduction of Paooj. Their results did not reach levels of significance but did suggest a trend towards excess lactate production at low Pa<x>, levels.…”

Section: Discussionmentioning

confidence: 99%

Observations of Blood Lactate and Pyruvate Levels and Excess Lactate Production During and After Anaesthesia With and Without Hyperventilation

Chamberlain¹,

Lis²

1969

Survey of Anesthesiology

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Arterial blood levels of lactate and pyruvate and the production of excess lactate were studied in two groups of patients. One group of ten patients was anaesthetized with <1 per cent halothane, nitrous oxide and oxygen and allowed to breathe spontaneously. The second group of twelve patients was anaesthetized with nitrous oxide and oxygen, and additional trichloroethylene or papaveretum, and deliberately hyperventilated. No significant changes were found in lactate or pyruvate during anaesthesia in the first group, but there was a significant increase in the lactate: pyruvate ratio half an hour after recovery from the anaesthetic. Significant excess lactate production occurred during anaesthesia in the second group after hyperventilation had been in progress for half an hour. The excess lactate increased after 1 hour of hyperventilation and further increases were found half an hour after recovery from the anaesthetic. These findings are discussed in relation to the observed changes in blood-gas levels and acid-base balance and to the current knowledge of carbohydrate metabolism. BRITISH JOURNAL OF ANAESTHESIA TABLE I Age, sex and diagnosis of patients studied.

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The Effect of Hyperventilation on “Excess Lactate” Production During Anaesthesia

Cited by 17 publications

References 0 publications

Normal pregnancy: A model of sustained respiratory alkalosis

Normal pregnancy: A model of sustained respiratory alkalosis

Lactic Acidaemia Due to Hyperventilation in a Child with Severe Mental Retardation

Observations of Blood Lactate and Pyruvate Levels and Excess Lactate Production During and After Anaesthesia With and Without Hyperventilation

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