THE EFFECT OF HYPOTHALAMIC LESIONS ON SEXUAL BEHAVIOR AND ESTROUS CYCLES IN THE EWE<sup>1</sup>

Clegg, M. T.; Santolucito, John A.; Smith, J. D.; Ganong, William F.

doi:10.1210/endo-62-6-790

Cited by 50 publications

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“…Our observation that complete bilateral lesions of the VMH caused a significant reduction in female ferrets' acceptance of male neck grips coupled with increased display of aggressive behavior towards the stimulus male corroborates previous reports of reduced receptivity in a variety of vertebrate species including female whiptail lizard (Kendrick et al, 1995), rat (Clark et al, 1981;Mathews and Edwards, 1977;Pfaff and Sakuma, 1979), hamster (Malsbury et al, 1977), guinea pig (Goy and Phoenix, 1963), ewe (Clegg et al, 1958) and cat (Leedy and Hart, 1985) after the bilateral placement of VMH lesions. Partial lesions of the female ferret's VMH failed to disrupt the display of receptive behavior.…”

Section: Discussionsupporting

confidence: 91%

“…Disruptive effects of VMH lesions on females' receptive responsiveness during estrus were also reported in sheep (Clegg et al, 1958) and to a lesser extent in the cat (Leedy and Hart, 1985). We therefore compared the effects of lesions of the VMH and MPOA/AH on females' display of the limp acceptance behavior normally shown by sexually receptive female ferrets (Baum, 1976) in response to a male's neck grip.…”

Section: Introductionmentioning

confidence: 97%

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Ventromedial hypothalamic nucleus lesions disrupt olfactory mate recognition and receptivity in female ferrets

Robarts

Baum

2007

Hormones and Behavior

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Previous research showed that ferrets of both sexes rely on the perception of conspecifics' body odors to identify and motivate approach towards opposite-sex mating partners, and exposure to male body odors stimulated Fos expression in an olfactory projection circuit of female, but not male, ferrets that terminates in the ventromedial hypothalamic nucleus (VMH). We asked whether the female-typical preference of ferrets to approach male as opposed to female body odors in Y-maze tests would be disrupted by VMH lesions. Sexually experienced female ferrets were ovo-hysterectomized prior to receiving bilateral electrolytic lesions of the VMH, the preoptic area/anterior hypothalamus (POA/ AH) or a sham operation. Subsequently, while receiving estradiol benzoate, females that received either complete or partial bilateral lesions of the VMH approached volatile odors from an anesthetized male on significantly fewer trials than females given POA/AH lesions or a sham operation. Both groups of ferrets with VMH lesion damage reliably discriminated between volatile anal scents as well as urinary odors from the 2 sexes in home cage habituation/dishabituation tests, suggesting that their odor-based sex discrimination remained intact. Females with complete bilateral VMH lesions showed significantly lower acceptance of neck gripping from a stimulus male (receptivity) and more aggression towards the male than all other groups of female subjects. Estrogen-sensitive neurons in the VMH appear to play a central role in female-typical neural processing of odor inputs leading to a preference to seek out a male sex partner, in addition to facilitating females' sexual receptivity.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 97%

Ventromedial hypothalamic nucleus lesions disrupt olfactory mate recognition and receptivity in female ferrets

Robarts

Baum

2007

Hormones and Behavior

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“…In these circumstances, sexual interactions hasten LH release (Signoret, 1975) as is the case in the intact female (Lindsay ef at., 1975 (Clegg et al, 1958 ;Radford, 1967 ;Przekop and Domanski, 1970 (Signoret, 1970). Richard (1967) for this species ; they were maintained under halothane anesthesia (4 to 5 p. 100 in air).…”

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confidence: 99%

Effect of hypothalamic deafferentation on LH and sexual behaviour in ovariectomized ewe under hormonally induced oestrous cycle

Thiéry¹,

Pelletier²,

Signoret³

et al. 1978

Ann. Biol. anim. Bioch. Biophys.

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“…This may imply that melatonin treatment of ovariectomized fallow deer does advances the period of responsiveness to oestradiol. As oestradiol is believed to regulate oestrous behaviour by acting on the hypothalamus (Clegg et al, 1958;Radford, 1967), the seasonal variation in the expression of oestrus may be due to a variation in the action of oestradiol on the hypothalamic-pituitary axis. In this study, the melatonin-treated deer were responsive in late February, some 8 weeks before the onset of the natural rut (the first natural mating in 1990 was recorded on 21 April); and contrary to other methods of advancing the onset of oestrus or ovulation in intact deer (pregnant mares' serum gonadotrophin: Adam et al, 1985;Asher & Smith, 1987; gonadotrophin-releasing hormone (GnRH): Asher & Macmillan, 1986) melatonin treatment has been shown to induce recurring reproductive activity in the nonbreeding season (Adam & Atkinson, 1984;Adam et al, 1986;Asher et al, 1988b McLeod et ai, 1991).…”

Section: Discussionmentioning

confidence: 99%

Effect of progesterone and oestradiol benzoate on oestrous behaviour and secretion of luteinizing hormone in ovariectomized fallow deer (Dama dama)

Jabbour¹,

Asher²,

Smith³

et al. 1992

Reproduction

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Summary. Eighteen ovariectomized fallow deer does and two adult bucks were used to investigate the effect of exogenous progesterone and oestradiol benzoate on oestrous behaviour and secretion of luteinizing hormone (LH). In Expts 1 and 2, conducted during the breeding season (April\p=n-\September), does were treated with intravaginal Controlled Internal Drug Release (CIDR) devices (0\m=.\3g progesterone per device) for 12 days and differing doses of oestradiol benzoate administered 24 h after removal of the CIDR device. The dose had a significant effect on the proportion of does that exhibited oestrus within the breeding season (P < 0\m=.\001), the incidence of oestrus being 100% with 1\m=.\0,0\m=.\1 and 0\m=.\05 mg, 42% for 0\m=.\01 mg and 0% for 0\m=.\002 mg oestradiol benzoate. There was a significant log\p=n-\linear effect of dose on the log duration of oestrus, which was 6\p=n-\20,2\p=n-\14,2\p=n-\12 and 2h after treatment with 1, 0\m=.\1,0\m=.\05 and 0\m=.\01 mg of oestradiol benzoate, respectively. Dose had a significant effect on the peak plasma LH concentration (P < 0\m=.\01), mean (\m=+-\s.e.m.)surge peaks of 27\m=.\7\ m=+-\ 2\m=.\3, 25\m=.\9\m=+-\1\m=.\8and 18\m=.\6\m=+-\3\m=.\4 ng/ml being observed following treatment with 1, 0\ m=. \ 1and 0\m=.\01 mg oestradiol benzoate respectively. In Expt 3, also conducted during the breeding season, progesterone treatment (0 vs. 6\p=n-\12 days) before the administration of 0\m=.\05mg oestradiol benzoate had a significant effect on the incidence of oestrus (0/6 vs. 10/12, P < 0\m=.\05), but not on LH secretion. The duration of progesterone treatment (6 vs. 12 days) had no effect on oestrus. In Expt 4, conducted in the nonbreeding season (October\p=n-\March), control does were largely unresponsive to treatment with 0\m=.\1 mg oestradiol benzoate. This was manifest in a lower proportion of does exhibiting oestrous behaviour and LH surges. Melatonin treatment, with implants administered on four occasions at intervals of 28\p=n-\30 days starting from 24 October, significantly increased the proportion of does that exhibited oestrus in February, during the later phase of the nonbreeding season (7/8 vs. 1/8, P < 0\m=.\05). Melatonin-treated does also exhibited significantly higher basal plasma LH concentrations after removal of CIDR devices in February (5\m=.\8\ m=+-\0\m=.\5vs. 2\m=.\1\m=+-\0\m=.\4 ng/ml, P < 0\m=.\01). While only one control doe had an LH surge, with a peak of 13\m=.\8 ng/ml, all melatonin-treated does exhibited LH surges, with a mean peak concentration of 58\m=.\0 \ m=+-\ 8\m=.\4 ng/ml.

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THE EFFECT OF HYPOTHALAMIC LESIONS ON SEXUAL BEHAVIOR AND ESTROUS CYCLES IN THE EWE¹

Cited by 50 publications

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Ventromedial hypothalamic nucleus lesions disrupt olfactory mate recognition and receptivity in female ferrets

Ventromedial hypothalamic nucleus lesions disrupt olfactory mate recognition and receptivity in female ferrets

Effect of hypothalamic deafferentation on LH and sexual behaviour in ovariectomized ewe under hormonally induced oestrous cycle

Effect of progesterone and oestradiol benzoate on oestrous behaviour and secretion of luteinizing hormone in ovariectomized fallow deer (Dama dama)

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THE EFFECT OF HYPOTHALAMIC LESIONS ON SEXUAL BEHAVIOR AND ESTROUS CYCLES IN THE EWE1

Cited by 50 publications

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Ventromedial hypothalamic nucleus lesions disrupt olfactory mate recognition and receptivity in female ferrets

Ventromedial hypothalamic nucleus lesions disrupt olfactory mate recognition and receptivity in female ferrets

Effect of hypothalamic deafferentation on LH and sexual behaviour in ovariectomized ewe under hormonally induced oestrous cycle

Effect of progesterone and oestradiol benzoate on oestrous behaviour and secretion of luteinizing hormone in ovariectomized fallow deer (Dama dama)

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THE EFFECT OF HYPOTHALAMIC LESIONS ON SEXUAL BEHAVIOR AND ESTROUS CYCLES IN THE EWE¹