The effect of <i>Allium cepa</i> extract on the chitosan/PLGA scaffolds bioactivity

Monárrez-Cordero, B.E.; Rodríguez-Gónzalez, C.A.; Valencia-Gómez, Laura Elizabeth; Hernández-Paz, J.F.; Martel-Estrada, Santos-Adriana; Camacho‐Montes, H.; Olivas–Armendáriz, I.

doi:10.1177/2280800021989701

Cited by 3 publications

(2 citation statements)

References 38 publications

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“…Allium cepa extract, chitosan and poly (DL-lactic-co-glycolic) acid have been employed for the synthesis of a 3D matrix with a porous morphology (50–100 µm), allowing its surface mineralization to have a uniform hydroxyapatite layer [ 138 ]. Cucurbitacin B was incorporated into a biomaterial scaffold based on a poly (lactidecoglycolide) and β-tricalcium phosphate from where it was linearly released, showing enhanced neovascularization (via VEGFR-related signaling pathways) and bone regeneration (via higher bone mineral density, bone volume and number of trabeculae).…”

Section: The Innovative Administration and Application Of Plant Extra...mentioning

confidence: 99%

Phytochemical Compounds Involved in the Bone Regeneration Process and Their Innovative Administration: A Systematic Review

Hanga-Farcaș

Miere

Filip

et al. 2023

Plants

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Bone metabolism is a complex process which is influenced by the activity of bone cells (e.g., osteocytes, osteoblasts, osteoclasts); the effect of some specific biomarkers (e.g., parathyroid hormone, vitamin D, alkaline phosphatase, osteocalcin, osteopontin, osteoprotegerin, osterix, RANKL, Runx2); and the characteristic signaling pathways (e.g., RANKL/RANK, Wnt/β, Notch, BMP, SMAD). Some phytochemical compounds—such as flavonoids, tannins, polyphenols, anthocyanins, terpenoids, polysaccharides, alkaloids and others—presented a beneficial and stimulating effect in the bone regeneration process due to the pro-estrogenic activity, the antioxidant and the anti-inflammatory effect and modulation of bone signaling pathways. Lately, nanomedicine has emerged as an innovative concept for new treatments in bone-related pathologies envisaged through the incorporation of medicinal substances in nanometric systems for oral or local administration, as well as in nanostructured scaffolds with huge potential in bone tissue engineering.

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Section: The Innovative Administration and Application Of Plant Extra...mentioning

confidence: 99%

Phytochemical Compounds Involved in the Bone Regeneration Process and Their Innovative Administration: A Systematic Review

Hanga-Farcaș

Miere

Filip

et al. 2023

Plants

View full text Add to dashboard Cite

show abstract

“…Allium cepa extract, chitosan and poly (DL-lactic-co-glycolic) acid have been em-ployed for the synthesis of a 3D matrix with porous morphology (50-100 um) allowing its surface mineralization with a uniform hydroxyapatite layer [135]. Cucurbitacin B was incorporated into a biomaterial scaffold based on poly (lactidecoglycolide) and β-tricalcium phosphate from where it was linearly released showing enhanced neovascularization (via VEGFR-related signaling pathways) and bone regeneration (via higher bone mineral density, bone volume and number of trabeculae).…”

Section: The Innovative Administration and Application Of Plant Extra...mentioning

confidence: 99%

Phytochemical Compounds Involved in the Bone Regeneration Process and Their Innovative Administration: A Systematic Review

Hanga-Farcaș¹,

Miere²,

Filip³

et al. 2023

Preprint

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Bone metabolism is a complex process which is influenced by the activity of bone cells (e.g., osteocytes, osteoblasts, osteoclasts), the effect of some specific biomarkers (e.g., parathyroid hormone, vitamin D, alkaline phosphatase, osteocalcin, osteopontin, osteoportegerin, osterix, RANKL, Runx2) and the characteristic signaling pathways (e.g., RANKL/RANK, Wnt/β, Notch, BMP, SMAD). Some phytochemical compounds such as flavonoids, tannins, polyphenols, anthocyanins, terpenoids, polysaccharides, alkaloids and others presented a beneficial and stimulating effect in the bone regeneration process due to pro-estrogenic activity, antioxidant and anti-inflammatory effects and modulation of bone signaling pathways. Lately, nanomedicine has emerged as an innovative concept for new treatments in bone related pathologies envisaged by incorporation of medicinal substances in nanometric systems for oral or local administration, as well as in nanostructured scaffolds with huge potential in bone tissue engineering.

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Dietary organosulfur compounds: Emerging players in the regulation of bone homeostasis by plant-derived molecules

2022

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The progressive decline of bone mass and the deterioration of bone microarchitecture are hallmarks of the bone aging. The resulting increase in bone fragility is the leading cause of bone fractures, a major cause of disability. As the frontline pharmacological treatments for osteoporosis suffer from low patients' adherence and occasional side effects, the importance of diet regimens for the prevention of excessive bone fragility has been increasingly recognized. Indeed, certain diet components have been already associated to a reduced fracture risk. Organosulfur compounds are a broad class of molecules containing sulfur. Among them, several molecules of potential therapeutic interest are found in edible plants belonging to the Allium and Brassica botanical genera. Polysulfides derived from Alliaceae and isothiocyanates derived from Brassicaceae hold remarkable nutraceutical potential as antiinflammatory, antioxidants, vasorelaxant and hypolipemic. Some of these effects are linked to the ability to release the gasotrasmitter hydrogen sulfide (H 2 S). Recent preclinical studies have investigated the effect of organosulfur compounds in bone wasting and metabolic bone diseases, revealing a strong potential to preserve skeletal health by exerting cytoprotection and stimulating the bone forming activity by osteoblasts and attenuating bone resorption by osteoclasts. This review is intended for revising evidence from preclinical and epidemiological studies on the skeletal effects of organosulfur molecules of dietary origin, with emphasis on the direct regulation of bone cells by plantderived polysulfides, glucosinolates and isothiocyanates. Moreover, we highlight the potential molecular mechanisms underlying the biological role of these compounds and revise the importance of the so-called 'H 2 S-system' on the regulation of bone homeostasis.

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The effect of Allium cepa extract on the chitosan/PLGA scaffolds bioactivity

Cited by 3 publications

References 38 publications

Phytochemical Compounds Involved in the Bone Regeneration Process and Their Innovative Administration: A Systematic Review

Phytochemical Compounds Involved in the Bone Regeneration Process and Their Innovative Administration: A Systematic Review

Phytochemical Compounds Involved in the Bone Regeneration Process and Their Innovative Administration: A Systematic Review

Dietary organosulfur compounds: Emerging players in the regulation of bone homeostasis by plant-derived molecules

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