The effect ofTreponema denticolaimmunoinhibitory protein on cytokine expression in T cells

TLR5 activation induces expression of the pro‐inflammatory mediator Urokinase Plasminogen Activator via NF‐κB and MAPK signalling pathways in human dental pulp cells

“…Treponema denticola is well known as a member of the red complex which is the most dangerous group causing periodontal disease and includes Porphytomonas gingivalis (Holt & Ebersole 2005). Recent reports have indicated that more than 50% of these strains were found in infected root canals (Siqueira et al, 2001, Lee et al 2004, Foschi et al 2006, Narayanan & Vaishnavi 2010, suggesting that T. denticola plays an important role in pulpal diseases. In the pathology of pulpal diseases, oral bacteria can contact the pulp from infection of the root canal and deep periodontal pocket or when dental caries destroys the hard tissue and progresses to the pulp (Rana et al 2009).…”