The effect of <i>Trichostrongylus tenuis</i> on the caecal mucosa of young, old and anthelmintic-treated wild red grouse, <i>Lagopus lagopus scoticus</i>

Watson, H.; Lee, D. L.; Hudson, Peter J.

doi:10.1017/s0031182000054056

Cited by 30 publications

(24 citation statements)

References 13 publications

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“…In infected red grouse, such xenobiotics may originate from primary T. tenuis infection or from secondary pathogen infection following caecal haemorrhaging (Watson et al . ). Further, both NR2F2 (alias COUP‐TFII) and PTPN1 are involved in regulating glucose homoeostasis, energy expenditure and adipogenesis (Li et al .…”

Section: Discussionmentioning

confidence: 97%

“…Trichostrongylus tenuis infection is localized to the caecum where adult worms cause haemorrhaging and tissue necrosis with substantial impact on grouse condition and fitness (Watson et al . ; Hudson et al . ; Delahay et al .…”

Section: Discussionmentioning

confidence: 99%

“…Adult worms burrow into the caecal walls where they cause haemorrhaging and necrosis with substantial impacts on grouse fitness (Hudson ; Watson et al . ; Hudson et al . ; Delahay et al .…”

Section: Introductionmentioning

confidence: 99%

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Genome‐wide association and genome partitioning reveal novel genomic regions underlying variation in gastrointestinal nematode burden in a wild bird

et al. 2015

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Identifying the genetic architecture underlying complex phenotypes is a notoriously difficult problem that often impedes progress in understanding adaptive eco-evolutionary processes in natural populations. Host-parasite interactions are fundamentally important drivers of evolutionary processes, but a lack of understanding of the genes involved in the host's response to chronic parasite insult makes it particularly difficult to understand the mechanisms of host life history trade-offs and the adaptive dynamics involved. Here, we examine the genetic basis of gastrointestinal nematode (Trichostrongylus tenuis) burden in 695 red grouse (Lagopus lagopus scotica) individuals genotyped at 384 genome-wide SNPs. We first use genome-wide association to identify individual SNPs associated with nematode burden. We then partition genome-wide heritability to identify chromosomes with greater heritability than expected from gene content, due to harbouring a multitude of additive SNPs with individually undetectable effects. We identified five SNPs on five chromosomes that accounted for differences of up to 556 worms per bird, but together explained at best 4.9% of the phenotypic variance. These SNPs were closely linked to genes representing a range of physiological processes including the immune system, protein degradation and energy metabolism. Genome partitioning indicated genome-wide heritability of up to 29% and three chromosomes with excess heritability of up to 4.3% (total 8.9%). These results implicate SNPs and novel genomic regions underlying nematode burden in this system and suggest that this phenotype is somewhere between being based on few large-effect genes (oligogenic) and based on a large number of genes with small individual but large combined effects (polygenic).

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

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Genome‐wide association and genome partitioning reveal novel genomic regions underlying variation in gastrointestinal nematode burden in a wild bird

et al. 2015

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“…T. tenuis is a caecal nematode of birds that reaches its highest prevalence and abundance in red grouse Lagopus lagopus scoticus, an economically important game bird endemic to Great Britain. High burdens of T. tenuis are severely detrimental to red grouse both individually and at the population level [22][23][24][25][26]. T. tenuis is an excellent candidate for a microsatellite-based study of genetic structure for two principal reasons.…”

Section: Introductionmentioning

confidence: 99%

Abundant variation in microsatellites of the parasitic nematode Trichostrongylus tenuis and linkage to a tandem repeat

Johnson

Webster

Adam

et al. 2006

Molecular and Biochemical Parasitology

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“…Adult worms burrow into the caecal walls where they cause haemorrhaging and necrosis with substantial downstream consequences for energy balance, fecundity and survival (Hudson ; Watson et al . ; Hudson et al . ; Delahay et al .…”

Section: Introductionmentioning

confidence: 99%

The role of parasite‐driven selection in shaping landscape genomic structure in red grouse (Lagopus lagopus scotica)

et al. 2015

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Landscape genomics promises to provide novel insights into how neutral and adaptive processes shape genome-wide variation within and among populations. However, there has been little emphasis on examining whether individual-based phenotype-genotype relationships derived from approaches such as genome-wide association (GWAS) manifest themselves as a population-level signature of selection in a landscape context. The two may prove irreconcilable as individual-level patterns become diluted by high levels of gene flow and complex phenotypic or environmental heterogeneity. We illustrate this issue with a case study that examines the role of the highly prevalent gastrointestinal nematode Trichostrongylus tenuis in shaping genomic signatures of selection in red grouse (Lagopus lagopus scotica). Individual-level GWAS involving 384 SNPs has previously identified five SNPs that explain variation in T. tenuis burden. Here, we examine whether these same SNPs display population-level relationships between T. tenuis burden and genetic structure across a small-scale landscape of 21 sites with heterogeneous parasite pressure. Moreover, we identify adaptive SNPs showing signatures of directional selection using F(ST) outlier analysis and relate population- and individual-level patterns of multilocus neutral and adaptive genetic structure to T. tenuis burden. The five candidate SNPs for parasite-driven selection were neither associated with T. tenuis burden on a population level, nor under directional selection. Similarly, there was no evidence of parasite-driven selection in SNPs identified as candidates for directional selection. We discuss these results in the context of red grouse ecology and highlight the broader consequences for the utility of landscape genomics approaches for identifying signatures of selection.

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The effect of Trichostrongylus tenuis on the caecal mucosa of young, old and anthelmintic-treated wild red grouse, Lagopus lagopus scoticus

Cited by 30 publications

References 13 publications

Genome‐wide association and genome partitioning reveal novel genomic regions underlying variation in gastrointestinal nematode burden in a wild bird

Genome‐wide association and genome partitioning reveal novel genomic regions underlying variation in gastrointestinal nematode burden in a wild bird

Abundant variation in microsatellites of the parasitic nematode Trichostrongylus tenuis and linkage to a tandem repeat

The role of parasite‐driven selection in shaping landscape genomic structure in red grouse (Lagopus lagopus scotica)

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