The effect of immunosuppression on resistance to Rhodococcus equi in mice

Bowles, Pamela M.; Woolcock, J. B.; Mutimer, M. D.

doi:10.1016/0165-2427(89)90172-4

Cited by 12 publications

(3 citation statements)

References 12 publications

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“…Data demonstrated that the cyclophosphamide inhibited neutrophil production in mice, as previously observed in dogs (Madarame et al 1997). Results of this paper support the findings in literature where increased lethality of R. equi in mice was associated with immunosuppression (Bowles et al 1989a,b, Yager et al 1991, Multimer & Woolcock 1992, Hondalus & Mussel 1994. Further studies are necessary to determine the cyclophosphamide effect in phagocytosis process.…”

Section: Resul Resul Resul Resul Results Ts Ts Ts Tssupporting

confidence: 82%

Pathogenicity of Rhodococcus equi in mice, isolated from environment, human and horse clinical samples

Costa

Machado²,

Krewer

et al. 2006

Pesq. Vet. Bras.

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Rhodococcus equi is a facultative intracellular pathogen associated with bronchopneumonia, mesenteric lymphadenitis and enterocolitis in foals. Although R. equi is likely to be found in every horse-breeding farm, the clinical disease is unrecognized in most of them. Capsule components, equi factor, micolic acid and some products encoded by the large 85-90Kb plasmid were described as virulence factors. However, the pathogenesis of R. equi infections and the sensibility of foals are not completely understood. The aim of this study was evaluate the virulence of R. equi isolated from human, horses and environment for mices. Nine strains carrying the 85-90Kb plasmid isolated from foal clinical specimens, one from immunodeficient human patient and six plasmidless strains (four isolated from feces, one from pasture and one from immunodeficient human patient) were inoculated in cyclophosphamide immunossuppressed mice. The pathological changes and viability of R. equi cells in the liver of mice was verified after the 3rd, 6th an 10th day after inoculation for horse and environmental isolates and for R. equi isolates from human patients on the 1st, 3rd and 6th day. During the necropsy procedures, infiltrate of macrophages and pyogranulomatous lesions were detected after the sixth pos-inoculation day in the liver and spleen. In horse isolates, only plasmid positive strains were virulent, but in human isolates both strains (plasmid positive e plasmid negative) were virulent. Both groups of the immunossupressed mice inoculated with R. equi isolated from environment showed pathological changes. All R. equi strains were unable to kill non imunossuppressed mice.

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Section: Resul Resul Resul Resul Results Ts Ts Ts Tssupporting

confidence: 82%

Pathogenicity of Rhodococcus equi in mice, isolated from environment, human and horse clinical samples

Costa

Machado²,

Krewer

et al. 2006

Pesq. Vet. Bras.

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“…Disease resulting from R equi is rare in adult horses and the few reported cases were all immunosuppressed (Roberts and others 1980, Genetzky and others 1982, Falcon and others 1985, Zink and others 1986, Freestone and others 1987, Vengust and others 2002). This is in agreement with reports that R equi is an important opportunistic pathogen in immunosuppressed human beings (Gray and others 2000, Simsir and others 2001) and mice (Bowles and others 1989, Yager and others 1991). This short communication describes the first reported case in which the lymphocyte subpopulations from an immunosuppressed horse infected with R equi were analysed.…”

Section: Case Study (× 109/litre) Normal Range (× 109/litre)∗ Monoclosupporting

confidence: 93%

B and T cell suppression in an Arabian horse with Rhodococcus equi infection

et al. 2004

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“…However, bacterial clearance vs. development of pneumonia is dose dependent. Mortality, bacterial burden and development of lesions similar to those seen in foals can be dramatically increased when mice are treated with the immunosuppressive drugs cyclophosphamide or cortisone acetate (Mutimer & Woolcock, 1982; Bowles et al , 1989a, b).…”

Section: Infections By R Equimentioning

confidence: 99%

Molecular and infection biology of the horse pathogenRhodococcus equi

Bargen

Haas

2009

FEMS Microbiol Rev

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The soil actinomycete Rhodococcus equi is a pulmonary pathogen of young horses and AIDS patients. As a facultative intracellular bacterium, R. equi survives and multiplies in macrophages and establishes its specific niche inside the host cell. Recent research into chromosomal virulence factors and into the role of virulence plasmids in infection and host tropism has presented novel aspects of R. equi infection biology and pathogenicity. This review will focus on new findings in R. equi biology, the trafficking of R. equi-containing vacuoles inside host cells, factors involved in virulence and host resistance and on host-pathogen interaction on organismal and cellular levels.

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The effect of immunosuppression on resistance to Rhodococcus equi in mice

Cited by 12 publications

References 12 publications

Pathogenicity of Rhodococcus equi in mice, isolated from environment, human and horse clinical samples

Pathogenicity of Rhodococcus equi in mice, isolated from environment, human and horse clinical samples

B and T cell suppression in an Arabian horse with Rhodococcus equi infection

Molecular and infection biology of the horse pathogenRhodococcus equi

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