The Effect of Improving Basic Preventive Measures in the Perioperative Arena on <i>Staphylococcus aureus</i> Transmission and Surgical Site Infections

Loftus, Randy W.; Dexter, Franklin; Goodheart, Michael J.; McDonald, Megan; Keech, John; Noiseux, Nicolas; Pugely, Andrew J.; Sharp, William J.; Sharafuddin, Melhem J.; Lawrence, Walter; Fisher, Mark; McGonagill, Patrick W.; Shanklin, Jennifer; Skeete, Dionne; Tracy, Chad R.; Erickson, Beth; Granchi, Thomas S.; Evans, Lance; Schmidt, Eli; Godding, Joshua; Brenneke, Raven; Persons, Deanna; Herber, Alexia; Yeager, Mark P.; Hadder, Brent; Brown, Jeremiah R.

doi:10.1001/jamanetworkopen.2020.1934

Cited by 47 publications

(101 citation statements)

References 28 publications

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“…Meticulous intravascular catheter disinfection contributes to an overall reduction in SSIs [161]. Several studies have demonstrated the importance of regional anesthesia for the success of TJA at least in terms of complication spectrum/rate [162,163].…”

Section: Intraoperative Care For Tja Patientsmentioning

confidence: 99%

Prevention of Prosthetic Joint Infection: From Traditional Approaches towards Quality Improvement and Data Mining

Gallo

Nieslanikova

2020

JCM

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A projected increased use of total joint arthroplasties will naturally result in a related increase in the number of prosthetic joint infections (PJIs). Suppression of the local peri-implant immune response counters efforts to eradicate bacteria, allowing the formation of biofilms and compromising preventive measures taken in the operating room. For these reasons, the prevention of PJI should focus concurrently on the following targets: (i) identifying at-risk patients; (ii) reducing “bacterial load” perioperatively; (iii) creating an antibacterial/antibiofilm environment at the site of surgery; and (iv) stimulating the local immune response. Despite considerable recent progress made in experimental and clinical research, a large discrepancy persists between proposed and clinically implemented preventative strategies. The ultimate anti-infective strategy lies in an optimal combination of all preventative approaches into a single “clinical pack”, applied rigorously in all settings involving prosthetic joint implantation. In addition, “anti-infective” implants might be a choice in patients who have an increased risk for PJI. However, further progress in the prevention of PJI is not imaginable without a close commitment to using quality improvement tools in combination with continual data mining, reflecting the efficacy of the preventative strategy in a particular clinical setting.

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Section: Intraoperative Care For Tja Patientsmentioning

confidence: 99%

Prevention of Prosthetic Joint Infection: From Traditional Approaches towards Quality Improvement and Data Mining

Gallo

Nieslanikova

2020

JCM

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“…During anesthesia, bacterial and viral contamination of the anesthesia workspace routinely occurs, largely due to activities of the anesthesiologist and/or nurse anesthetist caring for the patient throughout the case [1,[37][38][39][40]. Multiple steps can be followed to mitigate this risk, as follows.…”

Section: Ambulatory Surgery Without Aerosol Production Without Genermentioning

confidence: 99%

“…(f) Double glove before touching the patient's nose/mouth and remove the outer glove following contact (e.g., placement of a nasal cannula) [54][55][56]. (g) After patient positioning, wipe down equipment and high-touch surfaces with disinfection wipes that contain a quaternary ammonium compound and alcohol [40,49,[56][57][58][59]. (h) Provide data feedback by surveillance of Enterococcus, Staphylococcus aureus, Klebsiella, Acinetobacter, Pseudomonas, and Enterobacter spp.…”

Section: Ambulatory Surgery Without Aerosol Production Without Genermentioning

confidence: 99%

Strategies for daily operating room management of ambulatory surgery centers following resolution of the acute phase of the COVID-19 pandemic

Dexter

Elhakim

Loftus

et al. 2020

Journal of Clinical Anesthesia

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Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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“…The study by Loftus et al 1 is an important addition to the literature supporting bundled infection prevention interventions to reduce the burden of surgical site infections (SSIs). The authors prospectively randomized patients undergoing a heterogeneous mix of surgical procedures to receive a standardized perioperative infection prevention bundle vs existing standard of care and followed patients for 60 days.…”

mentioning

confidence: 99%

“…What was the cost needed to prevent an infection? What is the value added by this bundled intervention designed to reduce the pathogen reservoir compared with existing Centers for Disease Control and Prevention recommendations 3 that target perioperative antibiotic administration and host optimization?Demonstrating a reduction in transmission events and infections was important, but Loftus et al1…”

mentioning

confidence: 99%

Bundled Interventions to Reduce Surgical Site Infections Are Effective and Urgently Needed

Forrester

2020

JAMA Netw Open

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The Effect of Improving Basic Preventive Measures in the Perioperative Arena on Staphylococcus aureus Transmission and Surgical Site Infections

Cited by 47 publications

References 28 publications

Prevention of Prosthetic Joint Infection: From Traditional Approaches towards Quality Improvement and Data Mining

Prevention of Prosthetic Joint Infection: From Traditional Approaches towards Quality Improvement and Data Mining

Strategies for daily operating room management of ambulatory surgery centers following resolution of the acute phase of the COVID-19 pandemic

Bundled Interventions to Reduce Surgical Site Infections Are Effective and Urgently Needed

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