The effect of inbreeding on the redistribution of genetic variance of fecundity and viability in Tribolium castaneum

Fernández, Almudena; Toro, Miguel Á; López-Fanjul, Carlos

doi:10.1038/hdy.1995.149

Cited by 60 publications

(45 citation statements)

References 18 publications

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“…Inbreeding will tend to drive different alleles towards fixation in each line and therefore the lines should diverge (Robertson 1952). Such divergence has been reported in Tribolium casteneum (Pray and Goodnight 1995;Fernandez et al 1995) and Drosophila melanogaster (Fowler and Whitlock 1999). The present results (Table 2) also indicate significant genetic variation among the inbred lines (significant variation for all four traits is found among the W-I lines if analyzed separately).…”

Section: Discussionsupporting

confidence: 65%

Inbreeding Depression: Tests of the Overdominance and Partial Dominance Hypotheses

Roff¹

2002

Evolution

124

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Abstract. The two principal theories of the causal mechanism for inbreeding depression are the partial dominance hypothesis and the overdominance hypothesis. According to the first hypothesis, inbreeding increases the frequency of homozygous combinations of deleterious recessive alleles thereby decreasing fitness, whereas the overdominance hypothesis posits that inbreeding increases homozygosity and thus reduces the frequency of the superior heterozygotes. These two hypotheses make different predictions on the effect of crossing inbred lines: the overdominance hypothesis predicts that trait means will be restored to the outbred means, whereas the partial dominance hypothesis predicts that trait means will exceed those of the outbred population. I tested these predictions using seven inbred lines of the sand cricket, Gryllus firmus. Fourteen generations of brother-sister mating resulted in an inbreeding depression of 20-34% in four traits: nymphal weights at ages 14 days, 21 days, 28 days, and early fecundity. An incomplete diallel cross of these lines showed genetic variation among lines and an increase in all trait means above the outbred means, with three being significantly higher. These results provide support for the partial dominance hypothesis and are inconsistent with the overdominance hypothesis.

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Section: Discussionsupporting

confidence: 65%

Inbreeding Depression: Tests of the Overdominance and Partial Dominance Hypotheses

Roff¹

2002

Evolution

124

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“…These findings have been supported to some extent by empirical studies on model organisms (e.g., García et al 1994;Fernandez et al 1995;Whitlock and Fowler 1999). Hallander and Waldmann (2007) investigated the importance of nonadditive genetic interactions when truncation selection was applied to a breeding population.…”

supporting

confidence: 58%

Efficient Markov Chain Monte Carlo Implementation of Bayesian Analysis of Additive and Dominance Genetic Variances in Noninbred Pedigrees

Waldmann¹,

Hallander²,

Hoti

et al. 2008

Genetics

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Accurate and fast computation of quantitative genetic variance parameters is of great importance in both natural and breeding populations. For experimental designs with complex relationship structures it can be important to include both additive and dominance variance components in the statistical model. In this study, we introduce a Bayesian Gibbs sampling approach for estimation of additive and dominance genetic variances in the traditional infinitesimal model. The method can handle general pedigrees without inbreeding. To optimize between computational time and good mixing of the Markov chain Monte Carlo (MCMC) chains, we used a hybrid Gibbs sampler that combines a single site and a blocked Gibbs sampler. The speed of the hybrid sampler and the mixing of the single-site sampler were further improved by the use of pretransformed variables. Two traits (height and trunk diameter) from a previously published diallel progeny test of Scots pine (Pinus sylvestris L.) and two large simulated data sets with different levels of dominance variance were analyzed. We also performed Bayesian model comparison on the basis of the posterior predictive loss approach. Results showed that models with both additive and dominance components had the best fit for both height and diameter and for the simulated data with high dominance. For the simulated data with low dominance, we needed an informative prior to avoid the dominance variance component becoming overestimated. The narrow-sense heritability estimates in the Scots pine data were lower compared to the earlier results, which is not surprising because the level of dominance variance was rather high, especially for diameter. In general, the hybrid sampler was considerably faster than the blocked sampler and displayed better mixing properties than the single-site sampler.

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“…Several studies have noted an increase in the amount of additive genetic variation following a bottleneck (Bryant et al, 1986;Lopez-Fanjul and Villaverde, 1989;Fernandez et al, 1995;Wade et al, 1996), and this result has been interpreted as inconsistent with a purely additive model of inheritance. The additive model does predict that the expected additive variance will be lower after a bottleneck, but there should be substantial variability around this expectation (with V A actually increasing in some replicates, eg Whitlock and Fowler, 1999).…”

Section: Inbreeding and Genetic Variancementioning

confidence: 83%

Inbreeding and the genetic variance in floral traits of Mimulus guttatus

Kelly

Arathi

2003

Heredity

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The additive genetic variance, V A , is frequently used as a measure of evolutionary potential in natural plant populations. Many plants inbreed to some extent; a notable observation given that random mating is essential to the model that predicts evolutionary change from V A . With inbreeding, V A is not the only relevant component of genetic variation. Several nonadditive components emerge from the combined effects of inbreeding and genetic dominance. An important empirical question is whether these components are quantitatively significant. We use maximum likelihood estimation to extract estimates for V A and the nonadditive 'inbreeding components' from an experimental study of the wildflower Mimulus guttatus. The inbreeding components contribute significantly to four of five floral traits, including several measures of flower size and stigma-anther separation. These results indicate that inbreeding will substantially alter the evolutionary response to natural selection on floral characters.

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The effect of inbreeding on the redistribution of genetic variance of fecundity and viability in Tribolium castaneum

Cited by 60 publications

References 18 publications

Inbreeding Depression: Tests of the Overdominance and Partial Dominance Hypotheses

Inbreeding Depression: Tests of the Overdominance and Partial Dominance Hypotheses

Efficient Markov Chain Monte Carlo Implementation of Bayesian Analysis of Additive and Dominance Genetic Variances in Noninbred Pedigrees

Inbreeding and the genetic variance in floral traits of Mimulus guttatus

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