The Effect of Increased Renal Venous Pressure on Renal Function

Doty, J. Wesley; Saggi, BH; Blocher, Charles R.; Pin, R; Fakhry, Itaf; Gehr, Todd W.B.; Sica, Dominic A.; Sugerman, H J

doi:10.1097/00005373-199901000-00057

Cited by 56 publications

(71 citation statements)

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“…Abnormal branching of the SMA causes renal venous hypertension, and an experimental animal model demonstrates that elevation in renal venous pressure leads to decreased renal artery blood flow and a reduced glomerular filtration rate as well as increased renin activity [24]. In a study measuring plasma renin and angiotensin II levels in a 23-year-old patient with neurosyphilis, blood tests demonstrated increased plasma renin and angiotensin II activity in the LRV despite the absence of renal artery stenosis or a renin-producing tumor.…”

Section: Discussionmentioning

confidence: 99%

Multidetector computed tomography findings and correlations with proteinuria in nutcracker syndrome

et al. 2009

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We evaluated the effectiveness of multidetector computed tomography (MDCT) as a diagnostic tool for nutcracker syndrome (NS) and its association with proteinuria. The angle and distance between the aorta and the superior mesenteric artery (SMA), the degree of difference in corticomedullary enhancement (DCE) between kidneys in the nephrographic phase of computed tomography, peak velocity ratio (PVR), and anteroposterior diameter ratio (APDR) in the sonogram were measured. The MDCT results, sonogram results, and the ratio of protein:creatinine were significantly different between NS patients and the controls. The area under the curve for angle, distance, and DCE were 0.895 +/- 0.058, 0.876 +/- 0.063, and 0.942 +/- 0.036, respectively. The cutoff values for angle and distance had sensitivity and specificity values of 96.2 and 80% for <22.4 degrees and 84.6 and 80% for <4.9 mm, respectively. The DCE had a sensitivity of 88.5% and a specificity of 100% for the positive scores. There were significant correlations between the degree of DCE and the ratio of protein:creatinine (r = 0.337, p = 0.031), and between distance and the ratio of protein:creatinine (r = -0.419, p = 0.006). We conclude that MDCT has diagnostic value for NS in children and that MDCT findings are correlated with proteinuria.

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Section: Discussionmentioning

confidence: 99%

Multidetector computed tomography findings and correlations with proteinuria in nutcracker syndrome

et al. 2009

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“…Bloomfield et al [2] found increased plasma renin activity in renal venous blood when the IAP in pigs was raised incrementally to 25 mmHg above baseline. Doty et al [7] raised the renal venous pressure to 30 mmHg by placing a loop around the renal vein and observed increased plasma renin activity in blood taken from the carotid artery. These changes were partially reversed by decreasing renal venous pressure.…”

Section: Discussionmentioning

confidence: 99%

Role of angiotensin II under prolonged increased intraabdominal pressure (IAP) in pigs

et al. 2003

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“…Impaired renal blood flow, diminished renal perfusion pressure, and a decrease in glomerular filtration rate elevate PRA. [3,16]. High PRA levels have been measured during PP [9].…”

Section: Discussionmentioning

confidence: 99%

Clonidine provides opioid-sparing effect, stable hemodynamics, and renal integrity during laparoscopic cholecystectomy

et al. 2001

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The Effect of Increased Renal Venous Pressure on Renal Function

Cited by 56 publications

References 0 publications

Multidetector computed tomography findings and correlations with proteinuria in nutcracker syndrome

Multidetector computed tomography findings and correlations with proteinuria in nutcracker syndrome

Role of angiotensin II under prolonged increased intraabdominal pressure (IAP) in pigs

Clonidine provides opioid-sparing effect, stable hemodynamics, and renal integrity during laparoscopic cholecystectomy

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