The effect of increasing tertiles of waist circumference on cardio-metabolic risk, adipokines and biomarkers of inflammation and oxidative stress in nascent metabolic syndrome

Jialal, Ishwarlal; Jialal, Ganesh; Devaraj, Sridevi; Adams‐Huet, Beverley

doi:10.1016/j.jdiacomp.2018.01.008

Cited by 4 publications

(1 citation statement)

References 24 publications

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“…Among the mechanisms that can be mentioned are the following: first, the breakdown of VAT through many steps can increase gluconeogenesis in the liver, hence reducing the very low-density lipoprotein (VLDL) output; this leads to impaired glucose tolerance and increased TG (42-45). Second, in inflammatory conditions, adipose tissue begins to release fat and produce cortisol and pro-inflammatory cytokines, such as adipokines, which itself affects metabolic health (42,43).…”

Section: Discussionmentioning

confidence: 99%

The mediatory effect of inflammatory markers on the association between a body shape index and body roundness index with cardiometabolic risk factor in overweight and obese women: a cross-sectional study

Mirzababaei,

Abaj,

Khosravinia

et al. 2023

Front. Nutr.

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BackgroundObesity affects body composition and anthropometric measurements. A Body Shape Index (ABSI) and Body Roundness Index (BRI) are reportedly associated with an increased risk of cardiovascular disease. However, the relationship between ABSI, BRI, cardiometabolic factors, and inflammatory elements is not well-elucidated. Therefore, this study sought to examine the mediatory effect of inflammatory markers on the association between ABSI and BRI with cardiometabolic risk factors in overweight and obese women.MethodsThis cross-sectional study was performed on 394 obese and overweight women. The typical food intake of individuals was assessed using a 147-item semi-quantitative Food Frequency Questionnaire (FFQ). Body composition was measured by bioelectrical impedance analysis (BIA). Biochemical parameters, such as inflammatory markers and anthropometric components, were also assessed. For each participant, all measurements were carried out on the same day.ResultThere was a significant positive association between ABSI and AC and CRI.I in subjects with higher ABSI scores before and after adjustment (P < 0.05). In addition, there was a significant positive association between BRI and FBS, TC, TG, AIP, AC, CRI.I, CRI.II, and TyG in participants with higher BRI scores before and after adjustment (P < 0.05). We found that hs-CRP, PAI-1, MCP-1, TGF-β, and Galectin-3 were mediators of these relationships (P < 0.05).ConclusionInflammation can play an important role in the relationship between body shape indices and cardiometabolic risk factors among overweight and obese women.

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Section: Discussionmentioning

confidence: 99%

The mediatory effect of inflammatory markers on the association between a body shape index and body roundness index with cardiometabolic risk factor in overweight and obese women: a cross-sectional study

Mirzababaei,

Abaj,

Khosravinia

et al. 2023

Front. Nutr.

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New paradigms in the study of the cholinergic system and metabolic diseases: Acetyl‐and‐butyrylcholinesterase

Villeda‐González,

Gómez‐Olivares,

Baiza‐Gutman

2024

Journal Cellular Physiology

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Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are enzymes that belong to the neuromuscular cholinergic system, their main function is to hydrolyze the neurotransmitter acetylcholine (ACh), through their hydrolysis these enzymes regulate the neuronal and neuromuscular cholinergic system. They have recently attracted considerable attention due to the discovery of new enzymatic and nonenzymatic functions. These discoveries have aroused the interest of numerous scientists, consolidating the relevance of this group of enzymes. Recent investigations have revealed a positive correlation between several risk factors for metabolic syndrome (MetS) and the expression of cholinesterases (ChE's), which underscore the impact of high ChE's activity on the pro‐inflammatory state associated with MetS. In addition, the excessive hydrolysis of ACh and other choline esters (succinylcholine, propionylcholine, butyrylcholine, etc.) by both ChE's results in the overproduction of fatty acid precursor metabolites, which facilitate the synthesis of very low‐density lipoproteins and triacylglycerols. Participation in these processes may represent the link between ChE's and metabolic disorders. However, further scientific research is required to fully elucidate the involvement of ChE's in metabolic diseases. This review aims to collect recent research studies that contribute to understanding the association between the cholinergic system and metabolic diseases.

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Apelin, Omentin-1, and Vaspin in patients with essential hypertension: association of adipokines with trace elements, inflammatory cytokines, and oxidative damage markers

Cinemre

Bahtiyar

et al. 2020

Ir J Med Sci

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The effect of increasing tertiles of waist circumference on cardio-metabolic risk, adipokines and biomarkers of inflammation and oxidative stress in nascent metabolic syndrome

Cited by 4 publications

References 24 publications

The mediatory effect of inflammatory markers on the association between a body shape index and body roundness index with cardiometabolic risk factor in overweight and obese women: a cross-sectional study

The mediatory effect of inflammatory markers on the association between a body shape index and body roundness index with cardiometabolic risk factor in overweight and obese women: a cross-sectional study

New paradigms in the study of the cholinergic system and metabolic diseases: Acetyl‐and‐butyrylcholinesterase

Apelin, Omentin-1, and Vaspin in patients with essential hypertension: association of adipokines with trace elements, inflammatory cytokines, and oxidative damage markers

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