The effect of injectable butaphosphan and cyanocobalamin on postpartum serum β-hydroxybutyrate, calcium, and phosphorus concentrations in dairy cattle

Rollin, E.; Berghaus, Roy D.; Rapnicki, Paul; Godden, Sandra; Overton, Michael W.

doi:10.3168/jds.2009-2508

Cited by 72 publications

(89 citation statements)

References 27 publications

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“…Although several studies had shown the positive effect of butaphosphan in reducing NEB intensity in high-producing dairy cows during the transition period (Furll et al, 2010;Rollin et al, 2010), its mode of action is not clear yet. What is known about the pharmacokinetics of this molecule is that it is rapidly eliminated from the organism after i.v.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have indicated (Furll et al, 2010;Rollin et al, 2010) that the injection of butaphosphan (2 to 8 g/cow) and cyanocobalamin (1 to 4mg/cow) in dairy cows, can reduce NEB intensity in a dose-dependent fashion with at least three injections of 2 g of butaphosphan and 1 mg of cyanocobalamin. Our results indicate that the use of 1 g of butaphosphan/cow, that is, half of the minimum dose used in other studies, is still able to induce positive effects on NEB and milk production.…”

Section: Discussionmentioning

confidence: 99%

“…The cyanocobalamin is a vitamin B involved in the synthesis of methionine, a donator of methyl for choline and carnitine. These two substances participate in the metabolism and transport of fat in the body (Rollin et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…Recently, a study has shown that cows treated with BTPC at calving and 1 day later had lower incidence of ketosis (Rollin et al, 2010). Another study also demonstrated that BTPC improved the energetic status of dairy cows during the peripartum period based on concentration of glucose, NEFA, BHB and cholesterol (Furll et al, 2010).…”

Section: Introductionmentioning

confidence: 97%

“…Overall, current treatments had limited success, and more research is needed. One potential alternative is the use of butaphosphan and cyanocobalamin (BTPC; vitamin B12) injections after calving, which have shown positive effects up to now (Furll et al, 2010;Rollin et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Effect of butaphosphan and cyanocobalamin on postpartum metabolism and milk production in dairy cows

Pereira

Silveira

Montagner

et al. 2013

Animal

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The aim of this study was to determine the effect of butaphosphan and cyanocobalamin (BTPC) supplementation on plasma metabolites and milk production in postpartum dairy cows. A total of fifty-two Holstein cows were randomly assigned to receive either: (1) 10 ml of saline (NaCl 0.9%, control group); (2) 1000 mg of butaphosphan and 0.5 mg of cyanocobalamin (BTPC1 group); and (3) 2000 mg of butaphosphan and 1.0 mg of cyanocobalamin (BTPC2 group). All cows received injections every 5 days from calving to 20 days in milk (DIM). Blood samples were collected every 15 days from calving until 75 DIM to determine serum concentration of glucose, non-esterified fatty acids (NEFA), b-hydroxybutyrate (BHB), cholesterol, urea, calcium (Ca), phosphorus (P), magnesium (Mg), aminotransferase aspartate (AST) and g-glutamyltransferase (GGT). The body condition score (BCS) and milk production were evaluated from calving until 90 DIM. Increasing doses of BTPC caused a linear reduction in plasma concentrations of NEFA and cholesterol. Supplementation of BTPC also reduced concentrations of BHB but it did not differ between the two treatment doses. Milk yield and milk protein had a linear increase with increasing doses of BTPC. A quadratic effect was detected for milk fat and total milk solids according to treatment dose, and BTPC1 had the lowest mean values. Concentrations of glucose, urea, P, Mg, AST, GGT, milk lactose and BCS were not affected by treatment. These results indicate that injections of BTPC during the early postpartum period can reduce NEFA and BHB concentrations and increase milk production in Holstein cows.Keywords: butaphosphan, cyanocobalamin, postpartum dairy cows, non-esterified fatty acid ImplicationsThis study presents a new metaphylactic strategy aimed to reduce the intensity of negative energy balance (NEB) in postpartum dairy cows. Unlike previous studies, the current protocol consists of five injections of cyanocobalamin and butaphosphan at 5 days interval during the first 20 days in milk (DIM), the period of greatest metabolic challenge for dairy cows. The results of this experiment indicate that this protocol can improve metabolic adaptation in the early postpartum period, by reducing adipose tissue mobilization and increasing milk production.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effect of butaphosphan and cyanocobalamin on postpartum metabolism and milk production in dairy cows

Pereira

Silveira

Montagner

et al. 2013

Animal

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Gluconeogenesis in dairy cows: The secret of making sweet milk from sour dough

et al. 2010

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SummaryGluconeogenesis is a crucial process to support glucose homeostasis when nutritional supply with glucose is insufficient. Because ingested carbohydrates are efficiently fermented to short-chain fatty acids in the rumen, ruminants are required to meet the largest part of their glucose demand by de novo genesis after weaning. The qualitative difference to nonruminant species is that propionate originating from ruminal metabolism is the major substrate for gluconeogenesis. Disposal of propionate into gluconeogenesis via propionyl-CoA carboxylase, methylmalonyl-CoA mutase, and the cytosolic form of phosphoenolpyruvate carboxykinase (PEPCK) has a high metabolic priority and continues even if glucose is exogenously supplied. Gluconeogenesis is regulated at the transcriptional and several posttranscriptional levels and is under hormonal control (primarily insulin, glucagon, and growth hormone). Transcriptional regulation is relevant for regulating precursor entry into gluconeogenesis (propionate, alanine and other amino acids, lactate, and glycerol). Promoters of the bovine pyruvate carboxylase (PC) and PEPCK genes are directly controlled by metabolic products. The final steps decisive for glucose release (fructose 1,6-bisphosphatase and glucose 6-phosphatase) appear to be highly dependent on posttranscriptional regulation according to actual glucose status. Glucogenic precursor entry, together with hepatic glycogen dynamics, is mostly sufficient to meet the needs for hepatic glucose output except in high-producing dairy cows during the transition from the dry period to peak lactation. Lactating cows adapt to the increased glucose requirement for lactose production by mobilization of endogenous glucogenic substrates and increased hepatic PC expression. If these adaptations fail, lipid metabolism may be altered leading to fatty liver and ketosis. Increasing feed intake and provision of glucogenic precursors from the diet are important to ameliorate these disturbances. An improved understanding of the complex mechanisms underlying gluconeogenesis may further improve our options to enhance the postpartum health status of dairy cows.

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Effects of intravenous butaphosphan and cyanocobalamin to late pregnant ewes on the metabolic indices around parturition and weight gain of their lambs after birth

Barimanloo

Chalmeh

Pourjafar

et al. 2021

Veterinary Medicine & Sci

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Background: Management and control of metabolic disorders in sheep around parturition is important. and various researchers have suggested different managerial solutions. Butaphosphan and cyanocobalamin are widely used for curing metabolic disorders resulting from poor nutrition, inadequate management or diseases.Objectives: It was hypothesised that butaphosphan and cyanocobalamin could improve the metabolism of ewes around parturition.Methods: Twenty-eight clinically healthy 3-year-old pregnant Afshari ewes from 21 days before parturition were enrolled into four equal groups: control (Ctrl), B+C1, B+C2 and B+C3. The Ctrl group only received intravenous normal saline and B+C1, B+C2 and B+C3 ewes, respectively, received an intravenous combination of 10% butaphosphan and 0.005% cyanocobalamin at 2, 4 and 6 ml/ewe, on Days 19-21, 10-12 and 1-3 before parturition. Blood samples were taken from all the ewes on Days 21, 12 and 3 before lambing at parturition day and on days 3, 12 and 21 after parturition.A body condition score of all the ewes was assessed at blood sampling days, and lambs born from the ewes were weighed at birth and every 2 weeks up to 3 months. Serum concentrations of glucose, cortisol, non-esterified fatty acids, beta-hydroxy butyric acid, triglyceride, cholesterol, high-, low-and very-low-density lipoproteins, aspartate aminotransferase and alanine aminotransferase were measured.Results: This drug combination decreased circulating glucose, cortisol, lipid profile and hepatic enzymes via dose-dependent manner, 6 ml of this drug compound/ewe was more potent than 4 and 2 ml/ewe. The lambs' weight from mothers receiving 6 ml of this combination was significantly higher than those of the others. Conclusions:It may be suggested that the intravenous administration of 6 ml/ewe of this combination for 3 consecutive days in three states before parturition had prophylactic effects on metabolic disorders of ewes and enhanced the lambs weight gain after birth.

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The effect of injectable butaphosphan and cyanocobalamin on postpartum serum β-hydroxybutyrate, calcium, and phosphorus concentrations in dairy cattle

Cited by 72 publications

References 27 publications

Effect of butaphosphan and cyanocobalamin on postpartum metabolism and milk production in dairy cows

Effect of butaphosphan and cyanocobalamin on postpartum metabolism and milk production in dairy cows

Gluconeogenesis in dairy cows: The secret of making sweet milk from sour dough

Effects of intravenous butaphosphan and cyanocobalamin to late pregnant ewes on the metabolic indices around parturition and weight gain of their lambs after birth

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