The Effect of Insulin on the Secretion of Gastric Juice in the Goat

Hill, K. J.

doi:10.1113/expphysiol.1952.sp000989

Cited by 8 publications

(3 citation statements)

References 2 publications

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“…The demonstration of a secretory response to insulin hypoglycaemia was at variance with previous results obtained in the lamb (Hitchcock et al 1948) and in the goat (Hill, 1952b), where inhibition of secretion was noted. The reason for this discrepancy is not known but the over-secretion which occurred in the present experiments when the reticulo-rumen contained food material indicated that the vagi exert considerable control over the gastric glands.…”

Section: Discijssioncontrasting

confidence: 56%

“…The effect of vagal stimulation on abomasal secretion Vagal stimulation brought about by insulin hypoglycaemia has been employed extensively in studies in gastric secretion (see Bachrach, 1953) and although previous investigations (Hitchcock, Karvonen & Phillipson, 1948;Hill, 1952b) had indicated that insulin hypoglycaemia was inhibitory to abomasal secretion it was deemed worth while to reinvestigate this point.…”

Section: The Flow Of Ingesta During Feedingmentioning

confidence: 99%

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Abomasal secretion in the sheep

Hill¹

1960

The Journal of Physiology

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Anatomically and histologically the true gastric secretory stomach of the ruminant, the abomasum, is strictly comparable to the simple stomach of other mammals. The composition of the gastric juice is similar to that found in other animals and it is reasonable to assume that the basic mechanisms governing secretion are also essentially similar. The cranial part of the ruminant digestive tract is, however, considerably modified for the storage and fermentation of plant material and it is of interest to ascertain to what extent the function of the abomasum is modified by the three compartments of the forestomach which lie between it and the oesophagus. Previous investigations (Hill, 1955) have shown that the continuous flow of ingesta from the reticulo-rumen to the abomasum is responsible for its continuous secretory activity, and that the abomasal glands are not able to secrete spontaneously. The experiments to be described were carried out to obtain further information about the factors responsible for initiating and maintaining abomasal secretion. METHODS Surgical preparationsOne-to two-year-old Clun Forest sheep were taken from pasture and placed in individual pens in the animal house, where they were allowed a week or two to become acclimatized before operation. Mineral supplements and a daily ration of 1000 g of chopped hay were provided for all animals.Rumen fistulae were prepared in all animals and were fitted with polyvinyl cannulae (Jarrett, 1948). Aboma8al fi8tulae. Perspex cannulae, 16 mm diameter and fitted with screw caps, were inserted into the pyloric region of the abomasum, and brought out through the abdominal wall.Crocker-Markowitz fistula. The duodenum was transected immediately caudal to the pyloric sphincter and a stainless-steel cannula (external diam. -7! in. (11 mm), internal diam. -6 in. (9-5 mm)) inserted into each end. The stems of the cannulae were brought out through the body wall and continuity of the digestive tract re-established by connecting the two cannulae with plastic tubing (Dougherty, 1955).Vagally innervated aboma8al pouche8 were prepared in nine sheep by a modified Hollander technique (Gregory, Hallenbeck & Code, 1942). Perspex or stainless-steel cannulae with 8-2

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Section: Discijssioncontrasting

confidence: 56%

Section: The Flow Of Ingesta During Feedingmentioning

confidence: 99%

Abomasal secretion in the sheep

Hill¹

1960

The Journal of Physiology

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“…Although established as a means of testing the integrity of the vagal innervation of fundic pouches in the dog (Jemerin, Hollander & Weinstein, 1943) it has not been used definitively in ruminants in which its effects on antral exocrine secretion do not appear to have been studied: in other species antral endocrine (gastrin) secretion is increased during insulin hypoglycaemia (Jaffe, McGuigan & Newton, 1970). Hill (1952) found reductions in acid secretion of abomasal pouches of the goat during insulin hypoglycaemia and in other experiments Hill (1968) found a stimulation of fundic acid secretion associated with reticulo-ruminal hypermotility. 20 00 secretion in a sheep (4) following the sxc.…”

Section: Resultsmentioning

confidence: 79%

Gastric, antral and fundic pouch secretion in sheep.

McLeay¹,

Titchen²

1975

The Journal of Physiology

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SUMMARY1. Fundic secretion of HC1 and pepsin was studied in sheep with both fundic and antral pouches. The antral pouches were of the entire pyloric region. Continuity of the alimentary tract was restored by an abomasoduodenal anastomosis.2. Secretion from fundic pouches was continuous. It was reduced in volume and acidity, as was pepsin output, by resection of the antral pouches.3. Teasing with food, feeding and injection of pentagastrin stimulated fundic acid and pepsin secretion in animals with antral pouches before and after antrectomy.4. Pouches prepared from the entire pyloric region showed continuous secretion with variations not related to feeding or fasting. Antral secretion was increased after s.c. injections of histamine, carbachol and pentagastrin.5. It is concluded that although the pyloric antrum contributes to the magnitude of the secretary response of an abomasal fundic pouch, the direction of the secretary response is similar whether or not the pyloric antrum is present as a separated pouch, or is removed.

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Neural and Hormonal Control of Gastric Secretion

Hirschowitz

1989

Comprehensive Physiology

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The Effect of Insulin on the Secretion of Gastric Juice in the Goat

Cited by 8 publications

References 2 publications

Abomasal secretion in the sheep

Abomasal secretion in the sheep

Gastric, antral and fundic pouch secretion in sheep.

Neural and Hormonal Control of Gastric Secretion

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