The Effect of Insulin Treatment on Fetal Mortality and Congenital Malformations in Diabetic Pregnant Women

Cohen, A.; Schenker, Joseph G.

doi:10.1007/978-1-4684-3219-0_30

Cited by 4 publications

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“…Elevated risks were observed for chromosomal defects as well as for cleft palatekleft lips. The combination of major malformations and the administration of insulin cannot be completely disregarded, but most authors view diabetes mellitus and not insulin as a risk factor [Cohen and Schenker, 1972;Miller et al, 1981;Mills, 1982;Molstedt-Pedersen, 1976;Soler et al, 19761. In the literature, mainly malformations of the musculoskeletal system, the nervous system, heart defects, and cleft palatekleft lips, as well as chromosomal aberrations, have been reported [Daw and Riley, 1984;Klingenberg et al, 1983;KuEera et al, 1965;Quaas et al, 1986;Schwaibold, 19851. Results obtained by our study therefore corroborate those reported in the literature.…”

Section: Discussionmentioning

confidence: 99%

Serial examination of 20,248 newborn fetuses and infants: Correlations between drug exposure and major malformations

et al. 1996

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Maternal medication during the first trimester of pregnancy has been discussed as a risk factor for development of birth defects. The correlation between maternal drug use and major malformations was investigated in a population-based case-control study in Mainz. Over a period of 5 years (1990-1994), 20,248 livebirths, stillbirths, and abortions underwent physical and sonographic examination, and anamnestic data were collected. A total of 1,472 births with congenital anomalies (cases) and 9,682 births without major and minor malformations (controls) were analyzed. We distinguished between 30 different drug categories, which were divided into medication taken continuously (before and during pregnancy; CM) and acute medication (drugs given within the first 3 months of gravidity; AM). Statistically highly-significant results [CM: Odds Ratios (OR) 1.2, Confidence Intervals (CI) 1.1-1.4, P = 0.008; AM: OR 1.2, CI 1.1-1.3, P = 0.008] were established for maternal drug use in correlation to birth defects. For the majority of combinations between drugs and specific malformations no teratogenic risks were found. However, statistically significant associations were recorded for antiallergics and heart anomalies (CM, AM) as well as musculoskeletal anomalies (AM); for bronchodilators and heart anomalies (CM, AM); for antiepileptics and anomalies of the internal urogenital system (CM), as well as cleft palate/cleft lips (AM); for thyroid hormones and anomalies of the nervous system (CM, AM), as well as anomalies of the external urogenital system (CM, AM); for insulin and anomalies of the musculoskeletal system (CM); for digitalis and anomalies of the musculoskeletal system (AM).

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Section: Discussionmentioning

confidence: 99%

Serial examination of 20,248 newborn fetuses and infants: Correlations between drug exposure and major malformations

et al. 1996

View full text Add to dashboard Cite

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“…The combination of major malformations and the administration of insulin cannot be completely disregarded, but most authors view diabetes mellitus and not insulin as a risk factor [Cohen and Schenker, 1972;Miller et al, 1981;Mills, 1982;Molstedt-Pedersen, 1976;Soler et al, 19761. In the literature, mainly malformations of the musculoskeletal system, the nervous system, heart defects, and cleft palatekleft lips, as well as chromosomal aberrations, have been reported [Daw and Riley, 1984;Klingenberg et al, 1983;KuEera et al, 1965;Quaas et al, 1986;Schwaibold, 19851. Elevated risks were observed for chromosomal defects as well as for cleft palatekleft lips.…”

Section: Discussionmentioning

confidence: 99%

Serial examination of 20,248 newborn fetuses and infants: Correlations between drug exposure and major malformations

et al. 1996

View full text Add to dashboard Cite

Maternal medication during the first trimester of pregnancy has been discussed as a risk factor for development of birth defects. The correlation between maternal drug use and major malformations was investigated in a population‐based case‐control study in Mainz. Over a period of 5 years (1990–1994), 20,248 livebirths, stillbirths, and abortions underwent physical and sonographic examination, and anamnestic data were collected. A total of 1,472 births with congenital anomalies (cases) and 9,682 births without major and minor malformations (controls) were analyzed. We distinguished between 30 different drug categories, which were divided into medication taken continuously (before and during pregnancy; CM) and acute medication (drugs given within the first 3 months of gravidity; AM). Statistically highly‐significant results [CM: Odds Ratios (OR) 1.2, Confidence Intervals (CI) 1.1–1.4, P = 0.008; AM: OR 1.2, CI 1.1–1.3, P = 0.008] were established for maternal drug use in correlation to birth defects. For the majority of combinations between drugs and specific malformations no teratogenic risks were found. However, statistically significant associations were recorded for antiallergics and heart anomalies (CM, AM) as well as musculoskeletal anomalies (AM); for bronchodilators and heart anomalies (CM, AM); for antiepileptics and anomalies of the internal urogenital system (CM), as well as cleft palate/cleft lips (AM); for thyroid hormones and anomalies of the nervous system (CM, AM), as well as anomalies of the external urogenital system (CM, AM); for insulin and anomalies of the musculoskeletal system (CM); for digitalis and anomalies of the musculoskeletal system (AM). © 1996 Wiley‐Liss, Inc.

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A mechanistic approach to teratogenesis: analysis of caudal dysplasia syndrome (sacral agenesis)

Kaplan¹

1979

Teratogenic Mechanisms

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The Effect of Insulin Treatment on Fetal Mortality and Congenital Malformations in Diabetic Pregnant Women

Cited by 4 publications

References 4 publications

Serial examination of 20,248 newborn fetuses and infants: Correlations between drug exposure and major malformations

Serial examination of 20,248 newborn fetuses and infants: Correlations between drug exposure and major malformations

Serial examination of 20,248 newborn fetuses and infants: Correlations between drug exposure and major malformations

A mechanistic approach to teratogenesis: analysis of caudal dysplasia syndrome (sacral agenesis)

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