The effect of intestinal flora intervention on bone development in children: A systematic review and meta-analysis

Huang, Zefan; Zou, Cheng; Li, Xin; Jiang, Tao; Li, Yingxian; Zhu, Xiaojuan; Guo, Haibin; Zhou, Xuan; Du, Qing

doi:10.1016/j.ctcp.2022.101591

Cited by 6 publications

(5 citation statements)

References 55 publications

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“…A quasy experiment conducted in China by (Huang & Fawzi, 2019) said that the complementary food supplement YingYang Bao (YYB) was able to increase the concentration of HB, TB and BB in children, and reduce the risk of anemia and stunting. YYB contains macronutrients and micronutrients, which function to increase brain intelligence.…”

Section: Resultsmentioning

confidence: 99%

Analysis Stunting Prevention and Intervention: A Literatur Review

Marni

Soares

Wahyudi

et al. 2022

PICNHS

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The incidence of stunting in Indonesia is still high, various efforts have been made by the government to reduce stunting. Stunting is a health problem that often occurs in children which can result in decreased productivity and intelligence in adulthood. This study aims to analyze the prevention factors for stunting at the age of toddlers. Checklist Prisma has been used for registration of titles, abstracts, full texts and methodologies with the keywords Analysis AND stunting AND Prevention AND Intervention. The computerized databases that have been used to search for articles in this study are Science Direct, Pubmed, ProQuest and Google Scholar. Has used articles that report quantitative and qualitative research in journals published in the period 2017 to 2022. The method used in data analysis is thematic analysis. This literature review involved 29 selected articles. There were 8 main factors that could affect stunting, namely nutrition/nutrition, economic status, education/knowledge, sanitation/environment, geographic location, government/cross-sectoral policies, age of marriage and health education. Most of the factors that contribute to stunting prevention are the provision of macronutrient/micronutrient supplements in the form of zinc tablets to adolescent girls, pregnant women, and supplementary feeding to children under five. Most of the studies reported in these 29 articles used a qualitative, quantitative design and were conducted in Bangladesh, China, India, Indonesia, Pakistan, Peru, Nepal, USA and Zimbabwe. In all these articles it is reported that the incidence of stunting is still high in several countries and especially in Indonesia. This literature review reported using 29 articles that met the inclusion criteria from the Science Direct, Pubmed, ProQuest and Google Scholar databases. The results detect the main factors that influence the occurrence of stunting, namely malnutrition in the early 1000 days of life, while for prevention is giving blood/zinc tablets to adolescents, pregnant women.

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Section: Resultsmentioning

confidence: 99%

Analysis Stunting Prevention and Intervention: A Literatur Review

Marni

Soares

Wahyudi

et al. 2022

PICNHS

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“…The modulation of osteoporosis by probiotics has become increasingly popular in clinical practice. In a systematic review study ( Huang et al, 2022 ), it was found that gut flora significantly improves bone development in infants, children, and adolescents, and that gut flora interventions serve as effective supplementary supplements for bone development. Furthermore, clinical trial studies have demonstrated that supplementation with probiotics enhances bone metabolism and increases the abundance of SCFAS-producing bacterial species, ultimately reducing bone loss.…”

Section: Discussionmentioning

confidence: 99%

The causal relationship between gut microbiota and bone mineral density: a Mendelian randomization study

Wang,

Zhang,

Tang

et al. 2023

Front. Microbiol.

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BackgroundThe gut microbiota has emerged as an intriguing and potentially influential factor in regulating bone health. However, the causal effect of the gut microbiota on bone mineral density (BMD) appears to differ throughout various life stages.MethodsWe conducted a Mendelian randomization (MR) analysis to investigate the potential causal relationship between gut microbiota and BMD in five distinct age groups: 0–15, 15–30, 30–45, 45–60, and 60 years and older. The analysis employed three different methods, namely MR-Egger, weighted median, and Inverse-variance weighting, to ensure the robustness of our findings, a series of sensitivity analyses were also conducted, such as horizontal pleiotropy tests, heterogeneity tests, and leave-one-out sensitivity tests.ResultsIn the age group of 0–15 years, Eubacterium_fissicatena_group and Eubacterium_hallii_group were identified as risk factors for BMD. During the 15–30 age group, Phascolarctobacterium, Roseburia, and Ruminococcaceae_UCG_003 were found to be protective factors for BMD. In the 30–45 age group, Lachnospira genus demonstrated a protective effect on BMD, while Barnesiella and Lactococcus were identified as risk factors for BMD. Moving on to the 45–60 age group, Eubacterium_ventriosum_group, Lachnospiraceae_UCG_004, and Subdoligranulum were observed to be protective factors for BMD, while Eubacterium_coprostanoligenes_group, Fusicatenibacter, and Lactococcus were associated with an increased risk of BMD. In individuals aged 60 years and older, Fusicatenibacter and Ruminococcaceae_UCG_002 were also noted as risk factors for BMD. Conversely, Eubacterium_ruminantium_group, Ruminococcus_gauvreauii_group, Alistipes, and Coprococcus_3 were found to be protective factors for BMD, whereas Barnesiella and Sellimonas were identified as risk factors for BMD.ConclusionA robust causal relationship between gut microbiota and bone mineral density (BMD) exists throughout all stages of life, with Firmicutes phylum being the primary group associated with BMD across age groups. Gut microbiota linked with BMD primarily belong to the Firmicutes phylum across age groups. The diversity of gut microbiota phyla associated with BMD depicts relatively stable patterns during the ages of 0–45 years. However, for individuals aged 45 years and above, there is an observed increase in the number of gut microbiota species linked with BMD, and by the age of 60 years, a trend toward an increase in the Bacteroidetes phylum categories is proposed.

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“…It has been recently reported that modulating intestinal flora is a promising approach of improving bone mineral density and hight in infants, children, and adolescents. [ 21 ] In addition, importance of gut microbiota has also been attached to the childhood development of a variety of organs, such as brain, lung, as well as the immune system. [ 22 ] Therefore, a better understanding of the intestinal flora in children’s health and disease conditions will help us to hold the key to better clinical management.…”

Section: Discussionmentioning

confidence: 99%

Changes of intestinal flora in children with febrile seizure

Yang

Tian

2023

Medicine

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Febrile seizure (FS) is a highly recurrent neuro-system disorder in children that affects their nervous system development and quality of life. However, the pathogenesis of febrile seizures remains unclear. Our study aims to investigate the potential differences in the intestinal flora and metabolomics between healthy children and those with FS. By examining the relationship between specific flora and different metabolites, we hope to shed light on the pathogenesis of FS. Fecal specimens were collected from healthy children (n = 15) and children with febrile seizures (n = 15), and 16S rDNA sequencing was conducted to characterize intestinal flora. Subsequently, fecal samples from healthy (n = 6) and febrile seizure children (n = 6) were used to characterize metabolomics using linear discriminant analysis of effect size, orthogonal partial least squares discriminant analysis, Kyoto Encyclopedia of Genes and Genomes (pathway enrichment analysis), and Kyoto encyclopedia of genes and genomes topology analysis. Liquid chromatography-mass spectrometry was used to identify metabolites in the fecal samples. The intestinal microbiome in the febrile seizure children significantly differed from that in the healthy children at the phylum level. Ten differentially accumulated metabolites (xanthosine, (S)-abscisic acid, N-palmitoylglycine, (+/−)-2-(5-methyl-5-vinyl-tetrahydrofuran-2-yl) propionaldehyde, (R)-3-hydroxybutyrylcarnitine, lauroylcarnitine, oleoylethanolamide, tetradecyl carnitine, taurine, and lysoPC [18:1 (9z)/0:0] were considered the potential febrile seizure markers. Three metabolic pathways (taurine metabolism; glycine, serine, and threonine metabolism; and arginine biosynthesis) were found essential in febrile seizure. Bacteroides were significantly correlated with the 4 differential metabolites. Adjusting the balance of intestinal flora may be an effective method for preventing and treating febrile seizures.Abbreviations: FS = febrile seizure, KEGG = Kyoto encyclopedia of genes and genomes, LC-MS = liquid chromatographymass spectrometry, LDA = linear discriminant analysis, LEfSe = linear discriminant analysis of effect size, NC = normal control, OPLS-DA = orthogonal partial least squares discriminant analysis, VIP = variable importance of the projection.

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The effect of intestinal flora intervention on bone development in children: A systematic review and meta-analysis

Cited by 6 publications

References 55 publications

Analysis Stunting Prevention and Intervention: A Literatur Review

Analysis Stunting Prevention and Intervention: A Literatur Review

The causal relationship between gut microbiota and bone mineral density: a Mendelian randomization study

Changes of intestinal flora in children with febrile seizure

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