The Effect of Intragastric Balloon on Plasma Ghrelin, Leptin, and Adiponectin Levels in Patients with Morbid Obesity

Konopko-Zubrzycka, Marzena; Baniukiewicz, Andrzej; Wróblewski, Eugeniusz; Kowalska, Irina; Zarzycki, W; Górska, Maria; Dâbrowski, A

doi:10.1210/jc.2008-1083

Cited by 80 publications

(53 citation statements)

References 18 publications

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“…Our results are comparable to previous reports in which the weight loss was 14.7–17.8 kg and BMI loss was 5.7–6.7 kg/m 2 [12–14]. Similar results were obtained by others [5, 15–18], using various types of intragastric balloons. The mean weight loss fluctuated from 9.7 to17.8 kg in these studies 6 months following balloon insertion [5, 12–18].…”

Section: Discussionsupporting

confidence: 92%

“…Similar results were obtained by others [5, 15–18], using various types of intragastric balloons. The mean weight loss fluctuated from 9.7 to17.8 kg in these studies 6 months following balloon insertion [5, 12–18]. The fat mass decreased on average by 11.7 kg.…”

Section: Discussionsupporting

confidence: 91%

“…In a 6-month study with BIB, Konopko-Zubrycka documented a significant decrease in fasting glucose and insulin response. Similar results were seen by Mathus-Vliegen in their randomized study [5, 23]. …”

Section: Discussionsupporting

confidence: 90%

“…There are few available reports on the effect of gastric balloons on hormonal regulation in patients with morbid obesity [5, 22, 24]. Body weight is regulated by a complex system, including both peripheral and central factors.…”

Section: Discussionmentioning

confidence: 99%

“…Obese subjects who do not qualify for, or do not give consent to, bariatric surgical procedures constitute a therapeutic problem. An endoscopic method for the treatment of obesity, intragastric balloon, can be an option for this group of patients [5]. …”

Section: Introductionmentioning

confidence: 99%

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Effects of the Intragastric Balloon MedSil® on Weight Loss, Fat Tissue, Lipid Metabolism, and Hormones Involved in Energy Balance

et al. 2014

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BackgroundThe prevalence of obesity continues to increase worldwide. Because obesity is associated with a number health-related problems as well as a shortened life span, treating obesity is an important clinical concern. Although various treatments are currently available, many are not efficacious in the long term. Therefore, additional medical treatment options for morbidly obese individuals must be explored. In this study, we examined the effects of the intragastric balloon MedSil® on anthropometric measures and hormones associated with lipid and energy metabolism.MethodsTwenty-two obese patients underwent insertion of the intragastric balloon MedSil® following a clinical exam, body composition scan, and collection of blood samples. Six months following implantation of the balloon, additional anthropometric and serological measures were taken.ResultsSix months following insertion of the MedSil® balloon, we observed significant decreases in body weight, body mass index, and fat mass. Compared with baseline levels, ghrelin serum levels were increased significantly, while leptin, FGF21, and glycated hemoglobin levels significantly decreased, 6 months after balloon insertion.ConclusionsThe MedSil® intragastric balloon is a safe and effective treatment for morbid obesity, with positive effects on anthropometric measures and lipid metabolism.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of the Intragastric Balloon MedSil® on Weight Loss, Fat Tissue, Lipid Metabolism, and Hormones Involved in Energy Balance

et al. 2014

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Hidden dangers and updated labels on gastric balloons

Kolli

Ofosu

Gurram

et al. 2020

Clinical Case Reports

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Weight loss with or without intragastric balloon causes divergent effects on ghrelin cell expression

Mathus-Vliegen

Spångéus

Walter

et al. 2021

Obesity Science & Practice

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Objective: The mechanism of action of intragastric balloons in the treatment of obesity is not fully understood. One of the hypotheses is that balloons might have an effect on the fundus, the area of ghrelin production.Methods: Participants were randomized to a 13-week period of sham or balloon treatment followed by a 13-week period of balloon therapy in everyone. Blood samples for ghrelin levels were taken in the fasting state and after a breakfast at the start, after 13 and 26 weeks. Biopsies for ghrelin cell immunohistochemistry were taken from the fundus at endoscopy. Results:Seven participants entered the balloon-balloon (BB) group and 11 the sham-balloon (SB) group. Despite a considerable weight loss, a median À 17.9 kg (interquartile ranges À 23.8 to À 0.5) in the BB group and À 18.3 kg (À 22.7 to À 14.7) in the SB group, fasting ghrelin and meal-induced ghrelin response did not change.In the SB group, the number of ghrelin cells increased significantly (p 0.001) from 110.6 (83.6-118.9) to 160.2 (128.5-223.0) while on sham treatment and returned to initial levels, 116.3 (91.7-146.9) (p 0.001), when they received their first balloon.No significant changes in ghrelin cell numbers were observed in the BB group. Conclusion:In participants without a balloon, weight loss induced an increase in ghrelin cell numbers in the fundus, which was annulled by the subsequent placement of a balloon. The effect of a balloon might be explained by effects on ghrelin cell numbers or ghrelin cell activity.

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The Effect of Intragastric Balloon on Plasma Ghrelin, Leptin, and Adiponectin Levels in Patients with Morbid Obesity

Cited by 80 publications

References 18 publications

Effects of the Intragastric Balloon MedSil® on Weight Loss, Fat Tissue, Lipid Metabolism, and Hormones Involved in Energy Balance

Effects of the Intragastric Balloon MedSil® on Weight Loss, Fat Tissue, Lipid Metabolism, and Hormones Involved in Energy Balance

Hidden dangers and updated labels on gastric balloons

Weight loss with or without intragastric balloon causes divergent effects on ghrelin cell expression

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