The Effect of Intravenous Estrogens on Ground Substance

Schiff, Maurice; Burn, Helen

doi:10.1001/archotol.1961.00740020047005

Cited by 98 publications

(28 citation statements)

References 7 publications

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“…For example, LHRH has its major physiologic effects on the gonadotrophins and, thereby, on sex hor mones. Previous reports have shown that progester one causes anaphylaxis [26] and that estrogens are mast cell secretagogues [27][28][29], However, LHRH an tagonists do not increase either of these two steroid hormones [3]. Therefore, it seems unlikely that LHRH antagonists alter mast cell activity and no mecha nisms other than direct release of mediators from mast cells are implicated in either the potentiation of the response to the second injection in vivo or in the discrepancies in activities of the antagonists in the various tests.…”

Section: Discussionmentioning

confidence: 99%

Antagonistic Analogs of Luteinizing Hormone-Releasing Hormone Are Mast Cell Secretagogues

Morgan¹,

O’Neil²,

Coy³

et al. 1986

Int Arch Allergy Immunol

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The histamine-releasing activity of luteinizing hormone-releasing hormone (LHRH) antagonistic analogs has been documented. Antagonists of LHRH elicited in vitro histamine release from mast cells obtained from previously unexposed rats. Intradermal injection of the antagonists caused increased local skin permeability. Anaphylactoid reactions followed subcutaneous injection of the antagonists and in some cases these edematous reactions were accompanied by increased serum histamine levels. These studies show that these small peptides can cause mast cell degranulation and suggest that the neuropeptide, LHRH, may have modulating effects on the immune system.

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Section: Discussionmentioning

confidence: 99%

Antagonistic Analogs of Luteinizing Hormone-Releasing Hormone Are Mast Cell Secretagogues

Morgan¹,

O’Neil²,

Coy³

et al. 1986

Int Arch Allergy Immunol

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“…Ear molding, for example, has illustrated that neonatal cartilage is malleable within the first 6 weeks of life. 18–24 This had been attributed to elevated levels of circulating maternal estrogen, stimulating an overproduction of hyaluronic acid, as well as elevated gradients of transforming growth factor-beta. 25,26 This neonatal milieu allows for molding of cleft nasal cartilage in an analogous fashion.…”

Section: Introductionmentioning

confidence: 99%

Early Cleft Lip Repair Revisited: A Safe and Effective Approach Utilizing a Multidisciplinary Protocol

Hammoudeh

Imahiyerobo

Fan

et al. 2017

Plastic and Reconstructive Surgery - Global Open

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Background:The optimal timing for cleft lip repair has yet to be established. Advances in neonatal anesthesia, along with a growing body of literature, suggesting benefits of earlier cleft lip and nasal repair, have set the stage for a reexamination of current practices.Methods:In this prospective study, cleft lip and nasal repair occurred on average at 34.8 days (13–69 days). Nasal correction was achieved primarily through molding the nasal cartilage without the placement of nasal sutures at the time of repair. A standardized anesthetic protocol aimed at limiting neurotoxicity was utilized in all cases. Anesthetic and postoperative complications were assessed. A 3-dimensional nasal analysis compared pre- and postoperative nasal symmetry for unilateral clefts. Surveys assessed familial response to repair.Results:Thirty-two patients were included (27 unilateral and 5 bilateral clefts). In this study, the overall complication rate was 3.1%. Anthropometric measurements taken from 3-dimensional-image models showed statistically significant improvement in ratios of nostril height (preoperative mean, 0.59; postoperative mean, 0.80), nasal base width (preoperative mean, 1.96; postoperative mean, 1.12), columella length (preoperative mean, 0.62; postoperative mean, 0.89; and columella angle (preoperative mean, 30.73; postoperative mean, 9.1). Survey data indicated that families uniformly preferred earlier repair.Conclusions:We present evidence that early cleft lip and nasal repair can be performed safely and is effective at improving nasal symmetry without the placement of any nasal sutures. Utilization of this protocol has the potential to be a paradigm shift in the treatment of cleft lip and nasal deformity.

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“…The cause of this change is not yet known, but alterations in the basement membrane and ground substance have been suggested [9]. Paradoxically however, estrogen sreatment which is known to cause an increase in mucopoly saccharides [64] decreased pulmonary diffusing capacity [60]. This tuggests that reduction in diffusing capacity is not related to the mucopolysaccharides.…”

mentioning

confidence: 99%

Aging of Connective Tissue and Molecular Transport

Sobel¹

1968

Gerontology

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The Effect of Intravenous Estrogens on Ground Substance

Cited by 98 publications

References 7 publications

Antagonistic Analogs of Luteinizing Hormone-Releasing Hormone Are Mast Cell Secretagogues

Antagonistic Analogs of Luteinizing Hormone-Releasing Hormone Are Mast Cell Secretagogues

Early Cleft Lip Repair Revisited: A Safe and Effective Approach Utilizing a Multidisciplinary Protocol

Aging of Connective Tissue and Molecular Transport

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