The effect of intravenous lidocaine on hemodynamic response to endotracheal intubation during sufentanil-based induction of anaesthesia

Zou, Yi; Kong, Gaoyin; Wei, Lai; Ling, Yingzi; Tang, Yixun; Zhang, Le; Huang, Qian

doi:10.5114/ait.2020.99918

Cited by 8 publications

(7 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 23 In this case, the occurrence of drowsiness may also have been due to the analgesic effect of nalbuphine. Intravenous lidocaine blocks Na + channels in the heart, which inhibites sympathetic transmission and depresses the hemodynamic response, 26 and so the MAP decreases significantly in group L.…”

Section: Discussionmentioning

confidence: 99%

Effect of nalbuphine on rocuronium injection pain

Huang

Wang

et al. 2021

World Jnl Ped Surgery

View full text Add to dashboard Cite

ObjectiveRocuronium-associated intravenous injection pain occurs frequently in children during induction of anesthesia. The aim of this study was to systematically evaluate the benefits of nalbuphine in patients with rocuronium-associated injection pain.MethodsNinety children undergoing tonsillectomy and adenoidectomy in our hospital between October 2019 and September 2020 were randomly divided into the following groups, with 30 patients per group: control group (group C), lidocaine group (group L), and nalbuphine group (group N). Routine 0.1 mg/kg midazolam and 2 mg/kg propofol were injected intravenously. After sedation, children in group C, group L, and group N were administered an intravenous injection of saline, lidocaine (10 mg/mL), or nalbuphine hydrochloride (2 mg/mL), respectively, at a dosage of 0.1 mL/kg. Intravenous injection of rocuronium stock solution (0.6 mg/kg) was administered 2 minutes later. Pain was evaluated using Ambeshs 4-pointscale. The incidence of rocuronium injection pain was compared among the three groups, and postoperative adverse reactions, such as drowsiness, bradycardia, hypotension, and respiratory depression, were evaluated.ResultsThe incidence of injection pain among children in group N was significantly lower than that in group C and group L (p<0.05). The incidence of drowsiness in group N was significantly higher than that in the other groups (p<0.05). The incidences of hypotension, bradycardia, and respiratory depression were not significantly different among the three groups (p>0.05).ConclusionsIntravenous nalbuphine during induction of anesthesia effectively prevented rocuronium-associated injection pain in children. Drowsiness is a complication.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of nalbuphine on rocuronium injection pain

Huang

Wang

et al. 2021

World Jnl Ped Surgery

View full text Add to dashboard Cite

show abstract

“…Moreover, it also inhibits the release of adrenaline and catecholamine and alleviates the stress response caused by a surgical operation. [ 11 , 12 ] Studies have shown that intravenous application of 1.5 mg/kg lidocaine reduces hemodynamic changes during endotracheal intubation, extubation, and operation. [ 13 ] Our results showed that MAP decreased at T1 in both groups; however, it was significantly decreased in group L but not in group C. HR decreased at T1 in group L. These results indicate that low-dose lidocaine reduces the stress response caused by endotracheal intubation.…”

Section: Discussionmentioning

confidence: 99%

Effect of low-dose lidocaine on MEPs in patients undergoing intracranial tumor resection with propofol anesthesia: A randomized controlled trial

Liu

Wang

et al. 2022

Medicine

View full text Add to dashboard Cite

Objective: To investigate the effect of low-dose lidocaine on motor evoked potentials (MEPs) in patients undergoing intracranial tumor resection with propofol anesthesia. Methods: Forty patients who underwent intracranial tumor resection and required MEP monitoring were selected. They were randomly divided into the lidocaine group (group L, n = 20) and the control group (group C, n = 20) by computer-generated randomization. All patients were given propofol anesthesia under the guidance of the bispectral index. In group L, 1 mg/kg of lidocaine was injected intravenously during anesthesia induction. Then, lidocaine was continuously pumped at a speed of 1 mg/kg/h until the operation started. Group C was given an equal volume of normal saline. Heart rate (HR), mean artery pressure (MAP), and bispectral index were recorded before anesthesia induction (T0), 2 minutes after tracheal intubation (T1), and 35 minutes (T2), and 50 minutes (T3) after anesthesia induction. The amplitude and latency of MEP at T2 and T3, the total dosage of propofol after anesthesia induction, and adverse events before T3 were recorded. Results: Compared with those in group C, HR and MAP were significantly decreased at T1 in group L. No significant differences were observed in HR and MAP at T0, T2, and T3 between group L and group C. The total dosage of propofol and the incidence of adverse events were significantly lower in group L than in group C before T3. There were no significant differences in the amplitude and latency of MEP between the 2 groups at each time point. Conclusions: Low-dose lidocaine has no obvious effect on MEP in patients undergoing intracranial tumor resection. However, it increased hemodynamic stability, reduced propofol use, and decreased the incidence of adverse events.

show abstract

“…Lidocaine is a local anesthetic that can be given intravenously. It was reported that intravenous infusion of lidocaine could blunt the hemodynamic response to endotracheal intubation during induction of anaesthesia [21]. Hypotension is a common complication after induction of general anaesthesia and lidocaine-ketamine combination could significant decrease incidence of hypotension compared to ketamine when used for endotracheal intubation in patients with circulatory failure [22].Our study found that the fluctuation of MAP and HR after gastroscopy implanted in group L were lower than those in group S. In addition, IV lidocaine can reduce the incidence of cough in patients undergoing gastroscopy.…”

Section: Lidocaine Decreased the Incidence Of Bucking Response Durmentioning

confidence: 99%

Intravenous lidocaine Increases the Efficacy of Propofol Anesthesia for Gastroscope Implanted:A Randomised, Double-blind, Controlled Study

Fu¹,

Chen²,

Ren³

et al. 2021

Preprint

View full text Add to dashboard Cite

Backgroud: Gastroscope insertion is a distressing experience and propofol use for sedation can result in inhibition of circulation and respiration. Intravenous (IV) infusion of lidocaine has been shown to reduce propofol requirements during surgery.The goal of this study was to evaluate the impact of IV lidocaine on the median effective dose (ED50) of propofol and other outcomes after surgery. Method: Ninety adult patients undergoing analgesic gastroscopy were randomly divided into two groups (45 cases in each). The lidocaine group was slowly injected with 1% lidocaine at 1.5mg/kg while the saline group was given the same volume of saline before propofol induction. Motion and cough reaction were regarded as the judgment index of gastroscope implanted. The dose-response curves were made in the two groups when implanted gastroscope according to the formula of Y=Ymin+(Ymax-Ymin)/[1+10 log(ED50-X)*m ]. The primary outcome were the ED50 and requirement of propofol. Secondary outcomes were:intraoperative hemodynamic parameters,adverse reaction,awakening time,post-operative pain and fatigue. Results: Compared with the group S, the dose-response curve showing percentage of gastroscope implanted after propofol anesthesia in the L group shifted to the left. Intravenous infusion of lidocaine decreased the ED50 of propofol (group S 1.80mg/kg, group L 1.56mg/kg).Compared with group S, induction, additional requirement and total dose of propofol anesthesia, and incidence of bucking were significantly reduced in group L (P<0.05). Post-operative fatigue scores in group L were lower than that in group S (P < 0.05). Conclusion: Intravenous lidocaine could reduce the consumption of propofol anesthesia and reduce adverse reaction in patients undergoing painless gastroscopy. Trials registration: ChiCTR2000038542. Data of registration: Sep 23th, 2020.

show abstract

The effect of intravenous lidocaine on hemodynamic response to endotracheal intubation during sufentanil-based induction of anaesthesia

Cited by 8 publications

References 19 publications

Effect of nalbuphine on rocuronium injection pain

Effect of nalbuphine on rocuronium injection pain

Effect of low-dose lidocaine on MEPs in patients undergoing intracranial tumor resection with propofol anesthesia: A randomized controlled trial

Intravenous lidocaine Increases the Efficacy of Propofol Anesthesia for Gastroscope Implanted:A Randomised, Double-blind, Controlled Study

Contact Info

Product

Resources

About