The effect of intravenous medetomidine on pupil size and intraocular pressure in normotensive dogs

Verbruggen, A.; Akkerdaas, L. C.; Hellebrekers, L.J.; Stades, F. C.

doi:10.1080/01652176.2000.9695052

Cited by 39 publications

(55 citation statements)

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“…Nevertheless, in the present study, a significant decrease in PS was observed when compared with the insignificant changes in IOP. This result suggests that the changes in PS were not related to IOP, which is in agreement with the hypotheses and findings presented by Kanda et al (2015) and Verbruggen et al (2000).…”

Section: Discussionsupporting

confidence: 82%

“…Despite alterations in IOP in several dogs, these changes were insignificant and IOP remained within physiological limits (10-25 mmHg). Our observations are not in agreement with those of Verbruggen et al (2000), where an increase in IOP in four dogs, and a decrease in 10 dogs, 5 min after administration of medetomidine at 0.15 mg/m 2 body surface area (corresponds to approx. 0.005 mg/kg), was reported.…”

Section: Discussioncontrasting

confidence: 56%

“…0.005 mg/kg), was reported. The dose of medetomidine in the present study was two to four times higher when compared to the dose used by Verbruggen et al (2000). In our previous study (Rauser et al 2012), where we used comparable doses of medetomidine (0.3 mg/m 2 ) or more than twice the higher dose of dexmedetomidine used here (0.3 mg/m 2 ), we detected an increase in IOP 10 min after premedication before propofol administration.…”

Section: Discussionmentioning

confidence: 80%

“…Therefore, O 2 or CO 2 levels would not have influenced IOP. Verbruggen et al 2000 suggested that peripheral alpha-2 receptors exist in the eye and may be involved in the physiological regulation of IOP, which is not regulated by miosis only. Miosis was not accompanied by changes in IOP induced by medetomidine administration.…”

Section: Discussionmentioning

confidence: 99%

“…The first report of the influence of systemically administered medetomidine on IOP and PS in dogs was presented by Verbruggen et al (2000). They described an increase of IOP in four dogs, and a decrease of IOP in 10 dogs, 5 min after administration of medetomidine at 0.15 mg/m 2 body surface area (corresponds to approximately 0.005 mg/kg).…”

mentioning

confidence: 99%

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Influence of dexmedetomidine-propofol-isoflurane and medetomidine-propofol-isoflurane on intraocular pressure and pupil size in healthy dogs

Raušer¹,

Mrázová²,

Zapletalová³

2016

Vet. Med. - Czech

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ABSTRACT:The present prospective, randomised, double-blinded clinical study was designed to investigate the commonly used anaesthetic combinations of dexmedetomidine-propofol-isoflurane and medetomidine-propofolisoflurane on intraocular pressure and pupil size in dogs. Forty client-owned healthy dogs with no ocular abnormalities, average body weight of 25.7 ± 13.1 kg (mean ± SD) and aged 3.7 ± 2.7 years, were enrolled. Twenty four males and 16 females were included. Dogs were allocated randomly to receive dexmedetomidine i.v. at 0.005 mg/ kg, dexmedetomidine at 0.01 mg/kg, medetomidine at 0.01 mg/kg or medetomidine at 0.02 mg/kg. Ten minutes later anaesthesia was induced in all dogs with propofol and maintained with isoflurane in oxygen-air. Intraocular pressure, pupil size, heart rate, respiratory frequency and arterial blood pressures (SAP, DAP) were measured prior to (baseline) and at 10 (before propofol), 20, 30, 40, 50 and 60 min after dexmedetomidine or medetomidine administration. Oxygen saturation of haemoglobin (SpO 2 ) and end-tidal CO 2 concentration (EtCO 2 ) was monitored following anaesthesia induction. Data were analysed using Anderson-Darling and Bartlett's tests for data distribution and homogeneity of variance confirmation and ANOVA followed by Dunnett's tests for multiple comparisons. Changes were considered significant when P < 0.05. Following drug administration, pupil size, heart rate and respiratory frequency decreased significantly within groups, but did not differ between groups. No significant changes in intraocular pressure, SAP and DAP within and between groups, and SpO 2 or EtCO 2 between groups, were observed. Comparable doses of dexmedetomidine or medetomidine combined with propofol and isoflurane induced reductions in pupil size, respiratory frequency and heart rate, however, without a significant influence on intraocular pressure or arterial blood pressure.

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Section: Discussionsupporting

confidence: 82%

Section: Discussioncontrasting

confidence: 56%