The effect of intravenous tranexamic acid on reduction of seroma after para- umbilical hernioplasty

Abstract

Background: Para-umbilical hernioplasty is mostly safe but there are possible complications like seroma, wound infection and recurrence. Tranexamic acid is a synthetic derivative of the amino acid lysine that exerts an anti-fibrinolytic action through the reversible blockade of lysine binding sites on plasminogen molecules, used in the prevention and treatment of excessive bleeding both in primary and secondary care. Our study aimed to evaluate the effect of intravenous tranexamic acid injection on reduction of seroma after para-umbilical hernioplasty.Methods: We conduct a prospective controlled trial to compare the effect of intra-operative, intravenous single dose of tranexamic acid by a dose of 10 mg/kg body weight with induction of anaesthesia on the occurrence of local wound complications as seroma, wound infection in addition to time of drain removal and the amounts of drain output, by comparison between two groups.Results: Single intravenous dose of tranexamic acid with induction of anathesia reduced drain duration (P-value was 0.001), drain output in 1st day (P-value was 0.008), and drain output in 5th day (P-value was 0.036). Adverse effects were not observed.There were no significant difference in occurence of seroma (P-value was 0.429), and wound infection (P-value was 1.00).Conclusions: Our study revealed that tranexamic acid showed significant correlation with decrease duration of drains and fewer amounts of drain volumes in first day post-operative.

Evaluation of outcome of systemic tranexamic acid injection in drain output in ventral hernia repair

“…Even in patients with mastectomy tranexamic acid has well established role (23,24). Albatonanny has also found reduced risk among patients with single use of tranexamic acid in patients with ventral hernia (12). Use of Tranexamic acid in our study reduced postoperative drain output in patients with ventral hernia repair.…”

“…Studies have shown postoperative reduction in complications when tranexamic acid was used in patients of ventral hernia with reduced seroma formation, serous discharge and postoperative wound leakage as reported previously (16)(17)(18)(19)(20). A Study by Ahmed et al has found 81% patients with seroma formation but reduced in 5 days postoperatively and reduced drain output with use of tranexamic acid 1gm twice daily with short hospital stay (20).…”

“…In 1962, tranexamic acid was discovered, essential medicines used to treat major traumatic injuries, excessive bleeding injuries, post-partum bleeding, surgeries, bleeding from nose, removal of tooth, and heavy menstrual bleeding (8)(9)(10)(11). Tranexamic acid is an easily available drug and its cost-effective with no dose adjustment required and safe in hepatic impairment (11)(12)(13)(14)(15). Our study therefore designed to explore use of tranexamic acid in drain output.…”

Comparative study between herniorrhaphy alone versus hernioplasty in small-sized paraumbilical hernia

“…It can be the reason for postoperative wound infection, suppuration and hernia recurrence. 6 We had all our patients operated on by a fixed team of surgeons divided into two groups; group 1 with mesh repair and group 2 with only anatomical repair without mesh. All patients completed a 6-month follow-up period with interval reviews for detection of any complications.…”