The effect of jet lag on the human brain: A neuroimaging study

Zhang, Feifei; Li, Weikai; Li, Huiru; Gao, Shaobing; Sweeney, John A.; Jia, Zhiyun; Gong, Qiyong

doi:10.1002/hbm.24945

Cited by 16 publications

(8 citation statements)

References 41 publications

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“…Using computational models, Diekman and Bose (2018) report that this east‐west asymmetry stems from a combination of endogenous clock period (commonly >24 hours in humans) and external day length and predict that changes in day length may even induce jetlag when travelling from north to south 163 . On the other hand, Zhang et al (2020) reported that west‐to‐east jetlag induced brain and neuroendocrine changes that were related to jetlag symptoms 164 . Noteworthy, repeated long distance travel, as experienced by aircrews, may induce more severe health consequences than less extensive trans‐meridian travel.…”

Section: Modern Life Challenges To the Human Circadian Systemmentioning

confidence: 99%

Mammalian circadian systems: Organization and modern life challenges

Finger

Kramer

2020

Acta Physiologica

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Humans and other mammalian species possess an endogenous circadian clock system that has evolved in adaptation to periodically reoccurring environmental changes and drives rhythmic biological functions, as well as behavioural outputs with an approximately 24‐hour period. In mammals, body clocks are hierarchically organized, encompassing a so‐called pacemaker clock in the hypothalamic suprachiasmatic nucleus (SCN), non‐SCN brain and peripheral clocks, as well as cell‐autonomous oscillators within virtually every cell type. A functional clock machinery on the molecular level, alignment among body clocks, as well as synchronization between endogenous circadian and exogenous environmental cycles has been shown to be crucial for our health and well‐being. Yet, modern life constantly poses widespread challenges to our internal clocks, for example artificial lighting, shift work and trans‐meridian travel, potentially leading to circadian disruption or misalignment and the emergence of associated diseases. For instance many of us experience a mismatch between sleep timing on work and free days (social jetlag) in our everyday lives without being aware of health consequences that may arise from such chronic circadian misalignment, Hence, this review provides an overview of the organization and molecular built‐up of the mammalian circadian system, its interactions with the outside world, as well as pathologies arising from circadian disruption and misalignment.

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Section: Modern Life Challenges To the Human Circadian Systemmentioning

confidence: 99%

Mammalian circadian systems: Organization and modern life challenges

Finger

Kramer

2020

Acta Physiologica

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“…Thus, a proper functioning of the circadian clock is critical to maintain homeostasis and physiological functions, and the perturbation of this system may result in severe pathologies including cancer 41,42 . Abnormal changes in circadian rhythms have been reported in jet lag 43 , night-shift workers 44 , cancer 45,46 , metabolic disorders 47,48 , mental disorders 49,50 , and also as a consequence of spaceflight [51][52][53] . Space travellers report circadian rhythm disruption during spaceflight, which is visible in many physiological aspects, for example shorter sleep durations 54 .…”

Section: Introductionmentioning

confidence: 99%

Skeletal muscle gene expression dysregulation in long-term spaceflights and aging is clock-dependent

et al. 2023

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The circadian clock regulates cellular and molecular processes in mammals across all tissues including skeletal muscle, one of the largest organs in the human body. Dysregulated circadian rhythms are characteristic of aging and crewed spaceflight, associated with, for example, musculoskeletal atrophy. Molecular insights into spaceflight-related alterations of circadian regulation in skeletal muscle are still missing. Here, we investigated potential functional consequences of clock disruptions on skeletal muscle using published omics datasets obtained from spaceflights and other clock-altering, external (fasting and exercise), or internal (aging) conditions on Earth. Our analysis identified alterations of the clock network and skeletal muscle-associated pathways, as a result of spaceflight duration in mice, which resembles aging-related gene expression changes observed in humans on Earth (e.g., ATF4 downregulation, associated with muscle atrophy). Furthermore, according to our results, external factors such as exercise or fasting lead to molecular changes in the core-clock network, which may compensate for the circadian disruption observed during spaceflights. Thus, maintaining circadian functioning is crucial to ameliorate unphysiological alterations and musculoskeletal atrophy reported among astronauts.

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“…Although photoperiod cycle change can induce cognitive function deficit, it is also essential that photoperiod change can induce hippocampal shrinkage [41,42]. Hippocampal shrinkage is also the main basis for several mental diseases, including anxiety and depression [43,44].…”

Section: Social Jetlag and Brain Functionmentioning

confidence: 99%

Covid-19 pandemic quarantine and social jetlag

Sahraei¹,

Meftahi²,

Sahraei³

2021

Ukr.Biochem.J.

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Covid-19 pandemic forced the governments to choose the policy to the lockdown the gathering centers , including universities and schools to prevent the rapid spread of the disease, forcing millions of people to stay at home for several weeks and even more. Staying in the home for such long periods is associated with a change in the wake/sleep period (a kind of social jet lag) and the resulting alteration in feeding time and type of food. Moreover, the prevalence of anxiety and depression resulted from the reduction in physical activity and bad news also may help to worsen the social jetlag effect on these parts of society. Possible hazardous changes in this factor are reviewed in this study and some suggestions for better management of this condition are also offered. Pubmed, SCOPUS, WOS, and Google Scholar data banks were searched using the following keyword in combination and/or alone: jetlag, social jetlag, Chronobiology, photoperiod, metabolic disease, cardiovascular, sleep/weak period. Longtime lockdown gathering centers are shown to change the photoperiod cycle in people, and it may induce several consequences, including the effects on cognitive brain function, induce mental illness, metabolic syndrome, insulin resistance, mitochondrial aging, and cardiovascular diseases. Considering these facts, it is important to make rehabilitation programs for all the societies' members for post-pandemic time.

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The effect of jet lag on the human brain: A neuroimaging study

Cited by 16 publications

References 41 publications

Mammalian circadian systems: Organization and modern life challenges

Mammalian circadian systems: Organization and modern life challenges

Skeletal muscle gene expression dysregulation in long-term spaceflights and aging is clock-dependent

Covid-19 pandemic quarantine and social jetlag

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