The effect of Ketogenic diet on vitamin D3 and testosterone hormone in patients with diabetes mellitus type 2

AL-Msaid, Hayder L F; Khalfa, Hydar Muhsin

doi:10.2478/cipms-2020-0033

Cited by 3 publications

(3 citation statements)

References 19 publications

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“…In some studies, additional changes were observed in metabolic indices [11,50], inflammatory markers [51], or hormones [50]. An increase in circulating vitamin D3 was reported for patients with T2D on a KD compared to a control group or patients with T2D not on a KD [53]. We noted that only one study compared the effects of a KD to another diet [51].…”

Section: Intervention Studies In Healthy Adults and Patients With T2dmentioning

confidence: 94%

“…Human intervention studies that investigated the effects of KDs on vitamin D in healthy adults and patients with T2D are shown in Table 1. In total, five studies were done in healthy adults [11,[50][51][52] and one in subjects with T2D [53]. Regarding healthy participants, they were mostly obese (in three studies, only obese subjects were included), and the KD was prescribed as part of a weight-loss program [11,[50][51][52].…”

Section: Intervention Studies In Healthy Adults and Patients With T2dmentioning

confidence: 99%

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Ketogenic Diet and Vitamin D Metabolism: A Review of Evidence

et al. 2022

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The ketogenic diet (KD), which is low in carbohydrates and high to normal in fat and protein, has been traditionally used in epilepsy for the last 100 years. More recently, its application in obesity has been introduced. The present review aimed to investigate the effects of the KD on vitamin D. In total, five studies were done in healthy adults, one in subjects with type 2 diabetes, and seven in subjects with epilepsy that assessed the levels of vitamin D pre- and post-intervention. In the majority of studies, increases in circulating vitamin D were reported. The relationship of the KD with vitamin D was explained through several mechanisms: ketone bodies, macronutrient intake, the status levels of other fat-soluble vitamins, weight loss, changes in the hormonal milieu, and effects on gut microbiota. Moreover, potential nutrient–gene-related interactions were discussed. There is still a need to conduct multiple arm studies to compare the effects of the KD versus other diets and better decipher the particular effects of the KD on vitamin D levels and metabolism. Moreover, differentiations of the diet’s effects according to sex and genetic makeup should be investigated to prescribe KDs on a more personalized basis.

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Section: Intervention Studies In Healthy Adults and Patients With T2dmentioning

confidence: 94%

Section: Intervention Studies In Healthy Adults and Patients With T2dmentioning

confidence: 99%

Ketogenic Diet and Vitamin D Metabolism: A Review of Evidence

et al. 2022

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“…With body mass reduction by 15.1 kg, vitamin D concentration grew by 4.2 ng/mL on average [67]. In diabetic patients on a ketogenic diet, the concentration of vitamin D was significantly higher (mean concentration 53.5 ng/mL) than in those not using a ketogenic diet (mean concentration 25.1 ng/mL) [68].…”

Section: Thyroid Function Parameters (Tsh Ft3 Ft4)mentioning

confidence: 97%

Keto Menu–Effect of Ketogenic Menu and Intermittent Fasting on the Biochemical Markers and Body Composition in a Physically Active Man—A Controlled Case Study

Dyńka,

Paziewska,

Kowalcze

2023

Foods

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The combination of ketogenic diet (KD) with intermittent fasting (IF) has, for years, aroused a great interest in the scientific world and among healthy lifestyle enthusiasts. Its importance is even greater when the study subjects are physically active individuals. The aim of the study was a determination of the effect of strict calculated ketogenic menu combined with IF and with caloric deficit on the selected biochemical markers and body composition in a 23-year-old man performing strength training. At the same time, we decided to conduct the first so-deeply investigated and controlled case study in this respect. The study protocol included a 13-week-long ketogenic diet with intermittent fasting (of delayed time-restricted eating 16:8 type) and caloric deficit. A detailed menu was designed and was used by the man throughout the whole study duration. A number of blood tests were performed before and after the implemented dietary intervention. Additionally, body composition was determined weekly and the concentrations of glucose and ketone bodies, as well as pulse rate and arterial pressure, were measured daily. The most important changes noted included a significant increase in testosterone and vitamin D concentrations and significant reduction in the HOMA-IR index and concentrations of hepatic enzymes, insulin, glucose, iron, urea, and free triiodothyronine (FT3). Moreover, a significant improvement of body composition occurred (the ratio of total body mass to the adipose and muscular tissue and water mass improved). Favourable changes were also noted in heart rate and arterial pressure values. In view of that, the KD with IF and caloric deficit exerted favourable effects on most biochemical parameters and on body composition and caused an almost twofold increase in serum testosterone concentration.

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