The integumentary system covers the surface of the embryo (skin) and its specialized skin structures including hair, nails, sweat glands, mammary glands and teeth. During fetal skin development, the epidermis changes from a single layer of ectodermal cells at 7–8 days of gestation into a more apparent stratified, keratinized epithelium at 22–24 weeks. The aim of the study is to identify the histological and cytological changes that take place during neonatal and adult epidermis development. Human neonatal and adult samples were obtained from fully informed, consenting parent or releatives from Al-hilla mortary / Iraq. Neonatal samples were obtained from neonates after sudden deaths from maternity wards. Anatomical Sites included abdomen, forehead, back, shoulder and feet sole. A totoal of 15 neonates and 10 mature adults were used for this study. Fresh tissues were sectioned using a freezing cryostat. Tissues were sectioned at 5µm in -24°C and collected on microscopic slides. Slides were allowed to air dry for 30 min prior to hematoxyline and eosin staining. Tissues were also photographed using scanning electron microscopy SEM. Cytological measurements were taken using image j software and data was analysed using graph prism. Various cytological and histological changes takes place during neonatal and adult and epidermis development. Our study shows the stages of fair follicule formation as well as number of nucleated layers present at each stage of development and at different anatomical sites. Major histological changes takes places during the transition frm a neonate to a mature adult including the number of basal cells and epidermal thickness depending on the anatomical site.

Vitamin D is a fat-soluble steroid hormone. It obtained from foods or by the synthesis in the skin after sunlight exposure (Ultraviolet rays) and converted to the active form in the liver and kidneys. Vitamin D3 is highly affected by hormones of the menstrual cycle. Some evidence also suggests a possible role for vitamin D in the regulation of sexual function. There is no scientific evidence present that shows a relationship between marital status and vitamin D3 levels. The aim of this study is to investigate the correlation between vitamin D3 levels and marital status in females of different age groups in a given population. Methodology: A total of 140 females were randomly selected from the outpatient department in Al-Sader teaching hospital in Al-Najaf province Iraq in the period of December 2018 and March 2019. Venous blood (5 ml) was drawn from all subjects. Subjects were classified according to their marital status (single, married) and age groups.Subjects taking vitamin D3 supplementation were discarded from the study. Vitamin D3 and calcium analysis were determined from Human serum using ELISA microtiter plate. Calcium levels mg/dl were also determined using serum (Sysmex XP-300 Atomic Hematology Analyzer). Results: The results of this study showed that all females of all age groups suffered from hypovitaminosis D3 due to bone disorders. The levels of vitamin D3 in all age groups single females were significantly (P<0.05) lower than that in married subjects. Serum calcium levels were statistically significant (P<0.05) lower in females that are single compared to married females. Conclusion: Females that were single had lower vitamin D3 levels as well as lower serum calcium levels compared to those married. The outcome of this study shows that married females have higher vitamin D3 levels compared to that of single subjects.

Bone metastases are the main reason for death in males suffering from advanced prostate cancer. This study aimed to create zoledronic acid and graphene oxide conjugation for anticancer therapy. The process of conjugation was confirmed by several characterization methods including UV-VIS spectrophotometry, Fourier Transform Infrared Spectroscopy (FTIR), and atomic force microscope (AFM). the cytotoxicity of 400, 600, and 800 μg/ml to each GO, ZOL, and ZOL-GO was evaluated on a human hepatic cell line (WRL 68) and human prostate cancer cell line (PC3) using an MTT assay. The antitumor mechanisms of ZOL-GO were examined by cell cycle analysis. The results demonstrated That ZOL-GO caused a reduction in the cell viability of WRL 68 and PC3, with IC50 values of about 932.9 and 787.9 µg/ml respectively. The cell cycle distribution was evaluated after treating the prostate cancer cells (PC3) with 800µg/mL of ZOL-GO, the results showed the presence of a highly significant arresting effect in the G1 phase (P≤ 0.002) than the untreated cells (control). Our findings demonstrate the potential antitumor activity of using GO as a nanocarrier to improve the therapeutic efficacy of prostate cancer.

B vitamins are crucial for metabolism. They are chemically unique vitamins with a variety of uses that are often present in the same meals. The vitamin B often operates in concert to provide the body with a multitude of health advantages. The metabolism has been demonstrated to be supported and speeded up by vitamin B. Maintain toned muscles and healthy skin. Boost immune and nervous system performance. Improved red blood cell development and division help to avoid anemia. Together, these factors also assist in battling the signs and causes of stress, depression, and cardiovascular disease. Water-soluble and found throughout the body, all vitamin B. Any excess that is expelled in the urine daily replenishes them, and a vitamin B shortage may result in a wide range of health issues.

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