Objective: To study pregnancy and pregnancy outcomes in women with primary hyperparathyroidism (PHPT) and in controls. Design: Register-based retrospective cohort study of women aged 16-44 years with a diagnosis of PHPT with age-and gender-matched non-exposed controls in Denmark. Methods: The patients and controls were identified using the Danish National Hospital Discharge Register for the period 1977-2010. The outcomes were determined using the Birth Register, the Abortion Register and the LPR (National Hospital Discharge Register). The primary outcome was the relative risk of abortions in patients compared with controls. Results: A total of 1057 women with PHPT and 3171 controls were identified. The number of women giving birth and experiencing abortions did not differ between the two groups (live births, PZ0.21 and abortions, PZ0.12). Also birth weight, length, Apgar score, and gestation length at abortion did not differ. Within the first year after the diagnosis was made, gestation length was lower in women with PHPT than that in controls. However, this was linked to more deliveries by caesarian sections. Conclusions: A diagnosis of PHPT did not seem to increase the rate of abortions in our study. Reducing the abortion risk may therefore not be an indication for parathyroidectomy during pregnancy in patients with mild PHPT. The PHPT diagnosis does not seem to affect birth weight, length and Apgar score. The higher number of deliveries by cesarean section after the diagnosis was made may be associated with lower gestation age. The strategy for delivery should be carefully considered in pregnant women with PHPT.

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Aim: The cytotoxic effects of graphene oxide nanoparticles (GONPs) using MTT assays, observance of apoptotic markers, and oxidative stress were outlined. Materials & methods: Rat embryonic fibroblasts (REFs) and human epithelial breast cells (HBLs) were used at 250, 500 and 750 μg/ml concentrations. Results: Significant cytotoxic and apoptotic effects were observed. Analyses of CYP2E1 and malondialdehyde concentrations in REF and HBL-100 cell lines after exposing to GONPs confirmed the nanomaterials toxicity. However, the glutathione levels in REF and HBL-100 cell lines showed a substantial reduction compared with the control. The cytochrome CYP2E1, glutathione, malondialdehyde and caspase-3 alterations provided a plausible interlinked relationship. Conclusion: The study confirmed the GONPs cytotoxic effects on REF and HBL-100 cell lines. The outcome suggested caution in wide-spread applications of GONPs, which could have implications for occupational health also.

Retinol is lipid soluble vitamin widely used during pregnancy as a food supplement.The study has been conducted in Animal House/Faculty of Sciences/University of Kufa between December 2021 and February 2022, fifteen female Albino Rats are used. The present study has been intended to show the histolopathologiacl effects of retinol on blastocyst implantation in female Albino Rats. The females Rats are randomly divided into three main groups, comprising five rats for each group. The control group is given orally injection of physiological normal saline and the second and third group are given orally injection of retinol doses ten, twenty μcg/kg/day respectively for seven days from the first day to the end of experimental allocated for each female.The rats are sacrificed in 7 th (dpc) to study the implantation of embryos in decidual tissues. Retinol doses ten, twenty μcg/kg/day caused macroscopic malformations in embryos of female rats compare to control group. The histopathlogical  study of female rats embryos treated with ten, twenty μcg/kg/day of retinol have shown deformations of decidual tissues zonation.In conclusion; retinol caused malformations of embryos in 7 th (dpc) and histopathlogical effects in decidual tissue zonations of blastocyst.

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