The effect of labor on maternal and fetal vitamins C and E

Woods, James R.; Cavanaugh, Judith L.; Norkus, Edward P.; Plessinger, Mark A.; Miller, Richard K.

doi:10.1067/mob.2002.127131

Cited by 34 publications

(29 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An increase of oxidative processes during pregnancy is expressed by enhanced lipid peroxidation and a higher level of circulating markers of oxidative stress, such as lipid hydroperoxides and malondialdehyde. Accordingly, it has been reported that pregnant women exhibit consistently elevated levels of lipid peroxides, in particular during the second trimester [1]. In normal pregnancy, oxidative processes influence maternal cardiovascular adaptations, leading to an increase in the blood volume and cardiac output, while the systemic blood *Address correspondence to this author at the Department of Biomedical Sciences and Advanced Therapy, Section of Obstetrics and Gynecology University of Ferrara, Corso Giovecca 203, I-44100, Ferrara, Italy; E-mail: ves@unife.it pressure declines [2].…”

Section: Introductionmentioning

confidence: 99%

The Role and Modulation of the Oxidative Balance in Pregnancy

Biondi¹,

Pavan²,

Lunghi³

et al. 2005

CPD

View full text Add to dashboard Cite

Oxidative processes exert a fundamental regulatory function during pregnancy. It depends on the influence of oxygen, nitric oxide, reactive oxygen species and reactive nitrogen species metabolic pathways upon the vascular changes in the maternal organism, as well as on the regulation of uterine and cervical tone throughout gestation and delivery. These functions are strictly linked with the mediators of the inflammatory pathway. At the beginning of pregnancy, when a certain grade of inflammatory change is necessary to the trophoblast invasion of maternal tissue, the activation of the process by nitric oxide and reactive nitrogen species is welcome. Indeed, these products modulate the metalloproteinases, which are responsible for the remodelling of uterine extracellular matrix. At this stage estrogens are involved as well in the regulation of the delicate balance of pro-oxidant and anti-oxidant effects. Furthermore, reactive oxygen and nitrogen species appear to play an important role both in normal and pathologic embryogenesis. During advanced pregnancy, a derangement of the oxidative balance can lead to the improper activation of inflammatory changes, thus triggering premature labour as well as other complications, such as foetal growth restriction and preeclampsia. Although a number of pro- and anti-oxidant agents are available to influence the above-mentioned processes, there is no way to adequately measure the oxidative needs in single cases, in order to modulate the oxidative balance in clinical practice. Pharmacological research should be addressed to the development of new drugs, as well as to selective methods of delivery to the gestational tissues.

show abstract

Section: Introductionmentioning

confidence: 99%

The Role and Modulation of the Oxidative Balance in Pregnancy

Biondi¹,

Pavan²,

Lunghi³

et al. 2005

CPD

View full text Add to dashboard Cite

show abstract

“…This response affects the activity of matrix enzymes by producing mediators, such as prostaglandins and cytokines (8). In addition, free radicals induced oxidative stress (12) during pregnancy cause damage to fatty acids existing in fetal membranes (13,32,33). PPROM often represents a final path associated with infection, inflammation, uterine stretch, oxidative stress and decidual bleeding.…”

Section: Discussionmentioning

confidence: 99%

Effect of Zinc Supplement on Prevention of PPROM and Improvement of some Pregnancy Outcomes in Pregnant Women with a History of PPROM: A Randomized Double -Blind Controlled Trial

Shahnazi¹,

Khalili²,

Azimi³

2016

Iran Red Crescent Med J

View full text Add to dashboard Cite

Background: Preterm premature rupture of membrane (PPROM) prior to 37 weeks' gestation is among the most common obstetrics problems, which is associated with prenatal mortality and several maternal and neonatal complications. History of PPROM is a risk factor for recurrence. Zinc has an important effect on the strength of membranes by affecting collagen [tensile] strength -a substance with immunity mechanism and antioxidant properties.

show abstract

“…[25] Nevertheless, Woods et al reported that vitamin C concentrations were significantly lower in women during delivery as compared to women who underwent an elective caesarean section. [9] They postulated that this was due to generation of ROS, caused by repetitive ischemia and reperfusion of uterine tissue after each contraction.…”

Section: Concentration Course 6 Weeks and 3 Months After Deliverymentioning

confidence: 99%

“…[7] Labour is associated with generation of ROS and lipid peroxidation, [8] possibly due to repetitive ischemia and reperfusion. [9] Within 24 to 48 h after normal pregnancy a decrease is reported of lipid peroxides and antioxidant activity. [10] However, Nakai et al (2000) found a significant increase of the antioxidants superoxide dismutase and catalase in the first 24 h after delivery, which was ascribed to the physical stress and pain of labour.…”

Section: Introductionmentioning

confidence: 96%