The effect of Lactobacillus brevis on Apoptosis and casp (casp8, casp3) gene Expression in HeLa Cancer Cells

Chobdar, Neda; Ahmadizadeh, Changiz

doi:10.30699/ijmm.14.1.84

Cited by 3 publications

References 29 publications

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Lactobacillus, Bifidobacterium and Streptococcus, Probiotic Bacteria Supplements, Induce DNA Repair of Local Breast Cancer Cell Line AMJ13

Zaidi,

Al-Abdulwahid,

Hasan

2024

acopen

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General Background: Breast cancer is the most prevalent cancer affecting women, with increasing incidence worldwide. Specific Background: Recent research has focused on the role of epigenetic changes in DNA damage, repair mechanisms, and the potential therapeutic effects of probiotics. Probiotics have shown promise in promoting tissue regeneration and DNA repair. Knowledge Gap: However, the precise impact of probiotics on DNA repair in cancer cells, specifically breast cancer cells, remains underexplored. Aims: This study aimed to evaluate the effects of probiotics on DNA damage repair in AMJ13 Iraqi breast cancer cells and assess the cytotoxic effects of probiotics on these cells. Results: Using the comet assay, we found significant increases in DNA damage repair in AMJ13 cells treated with Lactobacillus plantarum (T1) and a combination of eight probiotic strains (T2). Exposure to T1 for 48 hours resulted in significant increases in tail DNA (P≤0.001), head DNA (P≤0.001), and tail moment (P<0.001), while T2 showed similar significant increases at 72 hours (P<0.05). Image analysis further supported the DNA repair potential of probiotics, as indicated by a small tail curve for treated cells. Novelty: This study provides novel insights into the therapeutic potential of probiotics in breast cancer treatment by demonstrating their capacity to enhance DNA repair mechanisms in cancer cells. Implications: The findings suggest that probiotic therapy may be a promising adjunct treatment in breast cancer, offering a new avenue for cancer management through the enhancement of DNA repair and reduction of DNA damage. Highlights: Probiotics significantly repaired DNA damage in breast cancer cells. T1 and T2 enhanced DNA repair within 48-72 hours. Probiotics offer potential as breast cancer adjunct therapy. Keywords: Breast cancer, probiotics, DNA repair, AMJ13 cells, cytotoxicity

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Lactobacillus, Bifidobacterium and Streptococcus, Probiotic Bacteria Supplements, Induce DNA Repair of Local Breast Cancer Cell Line AMJ13

Zaidi,

Al-Abdulwahid,

Hasan

2024

acopen

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Probiotics-based Anticancer Immunity In Cervical Cancer

Mahooti

Abdolalipour

Miri

et al. 2023

Probiotics in Anticancer Immunity

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In the recent past, many investigations have been directed toward finding the possible relationship between probiotic preventive-therapeutic effects and different cancers. Among different cancers, human papillomavirus (HPV)-induced cancer is the third most frequent cancer among women, resulting in being the second cause of death worldwide. Current treatments, such as chemotherapy and radiotherapy, have been shown to have some limitations, and the available effective cervical vaccines are costly, particularly in developing countries. Therefore, the researchers seek alternatives, such as natural components, as a new approach to treating and cure HPV-induced cancer. Among several natural components, probiotics have increasingly gained more attention due to the probiotic-associated immunomodulation and therapeutic efficacy shown in several studies, as well as their lower risk for human health. In this chapter, we have reviewed the association between probiotics and cervical cancer and discussed how probiotics could exert their effects to suppress or even inhibit the growth of cervical tumors, preclinically or clinically. The different aspects of probiotic application have been precisely studied to assess the potential of probiotics in improving or treating HPV-induced cancer. In addition, the effects of probiotics on immune responses have been described<br>

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Antiproliferative potential of Lactobacillus casei supernatant against MCF-7 breast cancer and HT-29 colorectal cancer cell lines

Haji Mehdi Nouri,

Tafvizi,

Amini

et al. 2023

gebsj

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The effect of Lactobacillus brevis on Apoptosis and casp (casp8, casp3) gene Expression in HeLa Cancer Cells

Cited by 3 publications

References 29 publications

Lactobacillus, Bifidobacterium and Streptococcus, Probiotic Bacteria Supplements, Induce DNA Repair of Local Breast Cancer Cell Line AMJ13

Lactobacillus, Bifidobacterium and Streptococcus, Probiotic Bacteria Supplements, Induce DNA Repair of Local Breast Cancer Cell Line AMJ13

Probiotics-based Anticancer Immunity In Cervical Cancer

Antiproliferative potential of Lactobacillus casei supernatant against MCF-7 breast cancer and HT-29 colorectal cancer cell lines

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