The Effect of Laparoscopic Sleeve Gastrectomy on Subclinical Atherosclerosis in Patients with Severe Obesity

Çekici, Yusuf; Kaya, Bedri Caner; Elkan, Hasan

doi:10.1007/s11695-020-05121-y

Cited by 10 publications

(4 citation statements)

References 40 publications

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“…In cohort studies, although most of the selected studies [ 16 , 32 , 33 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ] showed representativeness of the cases, the majority of them were distinguished by a lack of nonexposed group definition information. Since most of the studies did not include a control group, they were not assessed for comparability.…”

Section: Resultsmentioning

confidence: 99%

“… ( A ) Forest plot displaying standardized mean difference and 95% confidence intervals showing the consequence of bariatric surgery on IMT [ 16 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ]; ( B ) Leave-one-out sensitivity analyses indicating the effect of bariatric surgery on IMT [ 16 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , …”

Section: Figurementioning

confidence: 99%

“… Subgroup analysis based on the follow-up period [ 32 , 33 , 34 , 35 , 36 , 37 , 39 , 40 , 41 , 42 , 43 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ] ( A ) and type of surgery [ 33 , 37 , 38 , 39 , 40 , 41 , 42 , 45 , 49 , 50 , 52 , 53 , 54 , 58 , 59 , 60 ] ( B ). …”

Section: Figurementioning

confidence: 99%

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Effect of Bariatric Surgery on Intima Media Thickness: A Systematic Review and Meta-Analysis

Jamialahmadi

Reiner

Alidadi

et al. 2022

JCM

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Background: Obesity, and in particular extreme obesity, as a global health problem is an important risk factor for many diseases, including atherosclerotic cardiovascular disease (ACVD). Bariatric surgery might stop or slow atherogenesis by decreasing excessive weight in the early stages of atherogenesis, by suppressing low-grade systemic inflammation as well as by inhibiting oxidative stress and endothelial dysfunction. The aim of this meta-analysis was to provide an answer to whether bariatric surgery has a significant effect on intima-media thickness (IMT) which is a surrogate marker of early atherosclerosis and has a good correlation with atherosclerotic coronary heart disease. Methods: A systematic literature search in PubMed, Scopus, Embase, and Web of Science as well as grey literature was performed from inception to 1 July 2022. The meta-analysis was performed using Comprehensive Meta-Analysis (CMA) V3 software. Overall, the estimate of effect size was measured by a random effects meta-analysis. To account for the heterogeneity of studies regarding study design, characteristics of the populations, and treatment duration, a random-effects model (using the DerSimonian–Laird method) and the generic inverse variance weighting approach were used. To assess the existence of publication bias in the meta-analysis, the funnel plot, Begg’s rank correlation, and Egger’s weighted regression tests were used. Results: The meta-analysis of 30 trials, including 1488 subjects, demonstrated a significant decrease in IMT after bariatric surgery. The reduction in IMT was also robust in the leave-one-out sensitivity analysis. It must be stressed that the results of the random-effects meta-regression did not suggest any relationship between the changes in IMT and delta body mass index (BMI) or duration of follow-up after the bariatric surgery. However, the subgroup analyses showed a better IMT reduction after laparoscopic sleeve gastrectomy (LSG) when compared to Roux-en-Y gastric bypass (RYGB). Within a year, the IMT follow-up values showed a further improvement. Conclusions: Bariatric surgery significantly reduced IMT. Significant associations were found between the surgery type and IMT changes, as well as a significant effect of follow-up duration on the changes of IMT after bariatric surgery.

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Section: Resultsmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Section: Figurementioning

confidence: 99%

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Effect of Bariatric Surgery on Intima Media Thickness: A Systematic Review and Meta-Analysis

Jamialahmadi

Reiner

Alidadi

et al. 2022

JCM

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“…The effects of laparoscopic sleeve gastrectomy (LSG) operation on cIMT, epicardial fat thickness (EFT) and serum endocan levels, which are independent predictors of subclinical atherosclerosis, was investigated [36]. EFT, cIMT and serum endocan values decreased significantly in the sixth month after surgery (0.67 AE 0.15 vs. 0.60 AE 0.14 mm, P < 0.001; 1.07 AE 0.05 vs. 1.00 AE 0.14 mm, P < 0.001; and 89.18 AE 66.22 vs. 37.74 AE 15.37 pg/ml, P < 0.001, respectively) [36].…”

Section: Endocan and Carotid Artery Diseasementioning

confidence: 99%

Endocan: a new marker of endothelial function

Balta

Mikhailidis

2021

Current Opinion in Cardiology

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Purpose of reviewTo consider the role of endocan as an inflammatory marker in cardiovascular diseases. Recent findingsEndocan, an endothelial inflammatory marker, is associated with cardiovascular disease. SummaryVascular endothelial inflammation plays a key role in the pathogenesis of inflammatory and cardiovascular diseases by influencing thrombogenesis, tumour invasion and secretion of bioactive mediators. We discuss the role of endocan mainly in the context of cardiology.

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Impact of Bariatric Surgery on Carotid Intima-Media Thickness in Patients with Morbid Obesity: a Prospective Study and Review of the Literature

et al. 2022

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The Effect of Laparoscopic Sleeve Gastrectomy on Subclinical Atherosclerosis in Patients with Severe Obesity

Cited by 10 publications

References 40 publications

Effect of Bariatric Surgery on Intima Media Thickness: A Systematic Review and Meta-Analysis

Effect of Bariatric Surgery on Intima Media Thickness: A Systematic Review and Meta-Analysis

Endocan: a new marker of endothelial function

Impact of Bariatric Surgery on Carotid Intima-Media Thickness in Patients with Morbid Obesity: a Prospective Study and Review of the Literature

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