The Effect of Large Doses of Desiccated Thyroid on the Distribution and Metabolism of Albumin-I131 in Euthyroid Subjects1

Studies of Iodoalbumin Metabolism. Ii. The Effects of Thyroid Hormone*

“…The results of the present study and those of other investigators cited above (17,19) are in substantial agreement regarding the increase in rate of synthesis, increase in fractional rate of catabolism and reduction of total exchangeable albumin produced by thyroid hormone. These studies, however, shed no light on the mechanism whereby these changes are effected.…”

Radiothyroxine Turnover Studies in Thyroid Disease After Therapy

“…This would be consistent with previous evidence on serum protein metabolism, such as I131-tagged albumin turnover studies which have demonstrated the accelerating effect of thyroid hormone (7,17,18).…”

Albumin and gamma-globulin tracer studies in protein depletion states.

“…In a series of papers based on experimental reduction and expansion of the albumin pool size Rothschild and his colleagues (36)(37)(38)(39) concluded that the quantity of albumin degraded was related to albumin concentration or pool size. It would be of interest to know whether a fall in albumin catabolic rate is brought about by reduction of the serum albumin concentration or by contraction of either the intra-or extravascular pool.…”

“…These findings may correspond to our plasmapheresis experiments with ad libitum feeding and suggest that albumin synthesis will increase when protein is lost from the body, provided dietary nitrogen is adequate. In their series of experiments Rothschild and his colleagues (36)(37)(38)(39) concluded that synthesis of albumin was regulated by the colloidal osmotic pressure of plasma, not by the albumin concentration. This problem may not finally be answered until a direct method of measuring albumin synthesis is applied.…”