The effect of leptin gene polymorphisms on fertility traits in Japanese Black cattle

Kawaguchi, Fuki; Fukazawa, K.; Kohama, Namiko; Akiyama, Takayuki; Fukushima, Moriyuki; Kobayashi, Eiji; Oyama, Kenji; Mannen, Hideyuki; Sasazaki, Shinji

doi:10.2508/chikusan.87.333

Cited by 1 publication

(1 citation statement)

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“…LEP gene influences not only energy homeostasis and lipid metabolism but also reproductivity and heat resistance (Barb et al, 2001;Figueiredo et al, 2007). Actually, the T allele of c.239C > T shows a positive effect on fertility of Holstein-Friesian cattle (Komisarek, 2010), although similar effect was not observed in Japanese Black cattle (Kawaguchi et al, 2016). The possibility has also been suggested that the C allele of c.239C > T contributes to functional longevity of Holstein-Friesian cattle (Szyda et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Leptin gene contributes to beef marbling standard, meat brightness, meat firmness, and beef fat standard of the Kumamoto sub‐breed of Japanese Brown cattle

Matsumoto

Kimura

Nagai

et al. 2022

Animal Science Journal

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The Kumamoto sub-breed of Japanese Brown cattle has unique characteristics, such as great growth rate, and their contribution as future breeding materials is expected.To develop a DNA marker for their breeding, we investigated the effects of Leptin gene, controlling energy homeostasis, on carcass traits of the Kumamoto sub-breed.Sequence comparison identified five single nucleotide polymorphisms (SNPs): four linked synonymous mutations and one nonsynonymous mutation. Statistical analysis revealed that c.239C > T (p.A80V) had significant effects on the traits related with quality grade: beef marbling standard (p = 0.0132), meat brightness (p = 0.0383), and meat firmness (p = 0.0115). The C allele showed favorable effects; these scores of the C/C cattle were significantly higher than those of the C/T cattle. On the other hand, the effect of c.399T > C was observed on meat firmness (p = 0.0172) and beef fat standards (BFS) (p = 0.0129). The C/C cattle showed higher values of these traits than the T/T cattle. Our data suggested that these SNPs in Leptin gene could be used as a DNA marker for breeding of the Kumamoto sub-breed.

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