The effect of levetiracetam on rat bone mass, structure and metabolism

Fekete, Sona; Simko, J; Gradosova, Iveta; Maláková, Jana; Zivna, Helena; Palička, Vladimír; Živný, Pavel

doi:10.1016/j.eplepsyres.2013.08.012

Cited by 28 publications

(5 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[1527] A recent study in 108 patients concluded that newer generation (lamotrigine, topiramate, and clonazepam) AEDs are associated with low BMD. However, the patients were also on treatment with one of the conventional drugs leading to inability to arrive at conclusive evidence.…”

Section: Newer Antiepileptic Drugs and Bone Healthmentioning

confidence: 99%

Impact of antiepileptic drugs on bone health: Need for monitoring, treatment, and prevention strategies

Arora

Singh

Gupta

2016

J Family Med Prim Care

View full text Add to dashboard Cite

Epilepsy is the most common neurological disorder affecting approximately 50 million people worldwide. In India, overall prevalence of epilepsy is reported to be 5.59/1000 population. Antiepileptic drugs (AEDs) constitute the main-stay of treatment with a large number of AEDs available in the market. High incidence of adverse effects is a major limitation with AEDs. One of the major concerns is significant metabolic effects on the bone. However, little attention has been paid to this issue because most of the bone effects remain subclinical for a long time and may take years to manifest clinically. The main effects include hypocalcemia, hypophosphatemia, reduced serum levels of Vitamin D, increase in parathormone (PTH) levels, and alterations in bone turnover markers. The CYP450 enzyme-inducing AEDs such as phenytoin, phenobarbital, carbamazepine, and primidone are the most common AEDs associated with bone disorders while the data regarding the effect of valproate and newer AEDs such as lamotrigine, gabapentin, vigabatrin, levetiracetam, and topiramate on bone metabolism and bone density are scanty and controversial. Deficiency of Vitamin D is commonly described as a cause for the bone loss in epileptic patients while others being decreased absorption of calcium, increased PTH levels, and inhibition of calcitonin secretion, etc. However, there are no formal practical guidelines for the management of bone disease among those taking AEDs. Evidence-based strategies regarding monitoring, prevention, and treatment of bone diseases in patients on AED therapy are needed.

show abstract

Section: Newer Antiepileptic Drugs and Bone Healthmentioning

confidence: 99%

Impact of antiepileptic drugs on bone health: Need for monitoring, treatment, and prevention strategies

Arora

Singh

Gupta

2016

J Family Med Prim Care

View full text Add to dashboard Cite

show abstract

“…It is complicated to determine how high the risk will be in comparison to the other AEDs. In the case of levetiracetam (LEV) we monitored a significant decline of BMD on the same model in only 1 out of 4 locations of measurement (left femur), and moreover, we did not record significant changes in the mechanical durability of the bone 25 . In the case of LTG and TPM, we recorded on the same model both significant decline of BMD (at 3 measurement locations out of 4) and significant reduction in the mechanical durability of the bone (supplied data).…”

Section: Discussionmentioning

confidence: 86%

The effect of lacosamide on bone tissue in orchidectomised male albino Wistar rats

Simko¹,

Fekete²,

Maláková³

et al. 2015

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

Self Cite

View full text Add to dashboard Cite

show abstract

“…They postulated that there was a significant reduction of bone mineral density in LEV monotherapy-treated patients. In a preclinical study in 2013, Fekete et al 17 demonstrated a significant loss of femoral bone marrow density following LEV therapy and a decrease of osteoprotegerin serum levels (a marker of bone formation) with significant elevation of C-terminal telopeptide of collagen type I (a marker of bone resorption). In 2007, in a preclinical study, Nissen-Meyer et al…”

Section: Discussionmentioning

confidence: 99%

Levetiracetam and lamotrigine effects as mono- and polytherapy on bone mineral density in epileptic patients

El-Haggar

Mostafa

Allah

et al. 2018

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

The purpose of this study was to determine the effect of lamotrigine (LTG) and levetiracetam (LEV) as mono- and polytherapy on biochemical markers of bone turnover and bone mineral density in Egyptian adult patients with epilepsy. Methods Forty-eight patients were divided into four groups: two received monotherapy of either LTG or LEV, and the other two groups received polytherapy comprising (valproate [VPA] + LTG or VPA + LEV). Thirty matched healthy participants were included in the study. Participants completed a nutritional and physical activity questionnaire. Biochemical markers of bone and mineral metabolism and bone mineral density of the lumbar spine were measured at baseline and at six months. Results In the LEV monotherapy group, the bone formation markers showed a significant decrease in serum alkaline phosphatase and serum osteocalcin levels while the bone resorption marker showed a significant increase in urinary deoxypyridinoline levels. After six months of treatment, bone mineral density showed a significant decrease in all treated groups, while among monotherapy groups, this significant decrease was more prevalent in the LEV monotherapy group compared with the LTG monotherapy group. Furthermore, there was significant negative correlation between urinary deoxypyridinoline levels and bone mineral density in the LEV monotherapy group. Conclusion Using new generation antiepileptics, LEV monotherapies and polytherapy showed harmful effects on bone but LTG did not.

show abstract

The effect of levetiracetam on rat bone mass, structure and metabolism

Cited by 28 publications

References 19 publications

Impact of antiepileptic drugs on bone health: Need for monitoring, treatment, and prevention strategies

Impact of antiepileptic drugs on bone health: Need for monitoring, treatment, and prevention strategies

The effect of lacosamide on bone tissue in orchidectomised male albino Wistar rats

Levetiracetam and lamotrigine effects as mono- and polytherapy on bone mineral density in epileptic patients

Contact Info

Product

Resources

About