2012
DOI: 10.1177/1479164112445755
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The effect of levofloxacin and moxifloxacin on cardiovascular functions of rats with streptozotocin-induced diabetes

Abstract: Fluoroquinolone antibiotics cause rare, but clinically important, adverse events including hyperglycaemia and hypoglycaemia. The present study focuses on the possible effect of levofloxacin and moxifloxacin on the cardiovascular functions of rats with type I diabetes. Both antibiotics caused bradycardia. Levofloxacin but not moxifloxacin caused hypoglycaemia in diabetic rats and an increase in amplitude of the ST segment revealed by electrocardiogram (ECG) analysis of isolated hearts. In pressurized mesenteric… Show more

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Cited by 6 publications
(5 citation statements)
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“…These results were coincided with the results of Ravikumar et al (27) they noticed congestion, hemorrhages in cardiac muscle and inflammatory cells infiltration between myocytes after administration of 10 mg/kg bw and 20 mg/kg b.wt of levofloxacin for 4 weeks in chicken. Absi et al (28) noticed elongation of QT interval and ventricular fibrillation in addition to Dysglycaemia after intraperitoneal administration of levofloxacin to rats for 14 days. The findings of the present study are in accordance with Lin et al (9) study, they described that a mild degree of congestion, perivascular of mononuclear inflammatory cell infiltration in the myocytes was detected.…”
Section: Discussionmentioning
confidence: 99%
“…These results were coincided with the results of Ravikumar et al (27) they noticed congestion, hemorrhages in cardiac muscle and inflammatory cells infiltration between myocytes after administration of 10 mg/kg bw and 20 mg/kg b.wt of levofloxacin for 4 weeks in chicken. Absi et al (28) noticed elongation of QT interval and ventricular fibrillation in addition to Dysglycaemia after intraperitoneal administration of levofloxacin to rats for 14 days. The findings of the present study are in accordance with Lin et al (9) study, they described that a mild degree of congestion, perivascular of mononuclear inflammatory cell infiltration in the myocytes was detected.…”
Section: Discussionmentioning
confidence: 99%
“…This result, however, was not shown in diabetics who had been treated with several other antibiotic categories [7]. In another study on experimental animals, the treatment of STZ-induced diabetic wistar rats with fluoroquinolones may have improved the endothelial function of arterial blood vessels by promoting the action of SKCa, which constitutes a major part of EDHF function [8].…”
Section: Resultsmentioning
confidence: 94%
“…This result was not obtained in the groups of diabetics, who had been treated with several other categories of antibiotics [7]. As shown in another study in Aleppo university-Syria (2012) on experimental animals, an improved vascular function of EDHF was associated with the treatment of STZ-induced diabetic wistar rats with fluoroquinolone antibiotics, which was due to the enhancing of the pivotal function of SKCa channels [8]. However, these studies did not determine the effect of fluoroquinolones on plasma concentrations of CRP in these patients.…”
Section: Introductionmentioning
confidence: 85%
“…Following two weeks of adaption ، rats were randomly placed into six groups (seven rats/each group). group I negative control : healthy animals received 0.5ml normal saline ، group II positive control: received levofloxacin (LFX) dose of 50mg/kg/day intraperitoneally (IP) for fourteen days (22) ، group III positive control : received LFX 100mg/kg/day intraperitonially for fourteen days (23) ، group IV negative control : received vitamin D3 500 IU/day (24) orally by oral gavage for twenty one days ، group V received vitamin D3 500 IU/day orally for twenty one days and levofloxacin 50 mg/kg/day IP injected at day 8 for fourteen days ، group VI received vitaminD3 500IU/day for twenty one days orally and levofloxacin 100 mg/kg/day IP injected at day 8 for fourteen days.…”
Section: Experimental Protocolmentioning
confidence: 99%