Spinal cord injury (SCI) is one of the most debilitating diseases that affects all aspects of person’s life. Researches have indicated that life satisfaction in these patients is lower than that of others. The aim of this study was to investigate the effect of life skills training on life satisfaction in patient with spinal cord injury. This study, having a quasi-experimental design, was performed with pre-test, post-test, and control group. The statistical population of this study consisted of patients with spinal cord injury (only men) that is covered by the home health care team of the Kahrizak Charity Foundation of Tehran. To do research, 30 patients of the center were selected by availability sampling and were randomly divided into experimental and control groups. In the experimental group, 10 sections of life skills training were performed, while no intervention was used for the control group. The research tool used in this study was a Self-Life Satisfaction Questionnaire and a univariate analysis of covariance was used to test results. Findings from the analysis of covariance showed that there was a significant difference between experimental and control groups (p< 0,05). This indicated that life skills training improved the life satisfaction in patients with spinal cord injury.