The effect of lipocisplatin on cisplatin efficacy and nephrotoxicity in malignant breast cancer treatment

Vitamin A deficiency execrates Lewis lung carcinoma via induction of type 2 innate lymphoid cells and alternatively activates macrophages

“…Bronchoalveolar lavage (BAL) fluid and lung tissues were collected and analyzed as previously described (Cui et al, ; Li, Guabiraba, et al, ). The tumor size was calculated by using the following formula, V = 0.5 × L × W 2 , where L and W are the length and width of tumor (Li, Tian, et al, ).…”

In vivo pharmacokinetic and tissue distribution investigation of sustained-release cisplatin implants in the normal esophageal submucosa of 12 beagle dogs

“…To quantify the time profile of plasma total platinum concentration, blood samples (2 mL) were withdrawn from the hind limb vein at 0, 5, 10, 20, and 40 min and 1, 1.5, 2, 4, 8, 12, 24, 36, and 48 h after intravenous administration of CDDP, and at 0, 4,8,16,24,48,96,168,240,360,480, and 720 h after implantation of CDDP-NP. All samples were centrifuged (4000 rpm) for 10 min at 4 °C and stored at −20 °C until analysis with a graphite furnace atomic absorption spectrometer (GFAAS).…”

“…However, its use is limited by acquired resistance to CDDP and severe adverse effects on normal tissues, including nephrotoxicity, ototoxicity, neurotoxicity, and vomiting [3][4][5]. Various strategies have been explored to reduce these side effects, including the search for novel CDDP analogs associated with lower toxicity in normal tissues and hydration of the patient during CDDP treatment [6].…”

Characterization and cytotoxicity studies of DPPC:M2+ novel delivery system for cisplatin thermosensitivity liposome with improving loading efficiency

“…Although treatment with this drug is often effective, its therapeutic exploitation is limited by severe toxicities, including nephrotoxicity, ototoxicity, as well as other side effects such as nausea and vomiting [4]. Furthermore, the drug cisplatin Abbreviations: MAL, metal ion-assisted loading; DPPC, 1,2-dipalmitoyl-snglycero-3-phosphocholine; DSC, differential scanning calorimetry; FT-IR, Fouriertransform infrared; MTT, 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazoliu bromide; CH, cholesterol; AAS, atomic absorption spectrophotometry; EE, encapsulation efficiency; DMEM, Dulbecco's modified Eagle's medium; PBS, phosphatebuffered saline; RPMI, Roswell park memorial institute; DMSO, dimethylsulfoxide; ELISA, enzyme-linked immunosorbent assay.…”