The Effect of Locoregional Transarterial Infusion Chemotherapy on Liver Metastasis after Gastric Cancer Resection

Yy, Wang; Zhang, Wen; Shen, Qian; R, Liu; Zx, Kan; Jh, Wang

doi:10.1177/147323001204000334

Cited by 5 publications

(2 citation statements)

References 25 publications

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“…Compared with systemic chemotherapy, TACE has the unique advantage for delivering high-concentration drugs to metastases as well as to control systemic toxicity. A previous study[ 21 ] involving a small sample size demonstrated the effectiveness of TACE for treating GCLM. In the present study, Kaplan-Meier analysis indicated that the efficacy of TACE was similar to that of RFA.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of hepatectomy and palliative local treatments for gastric cancer patients with liver metastases: a propensity score matching analysis

Zhang

Gao

et al. 2017

Oncotarget

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BackgroundThe optimal treatments for gastric cancer with liver metastases (GCLM) remain controversial. This study aimed to evaluate the efficacy of hepatectomy, RFA and TACE as local treatments for GCLM.MethodsFrom 2001 to 2015, 119 consecutive patients who received multidisciplinary treatments based on curative gastrectomy and local treatments (hepatectomy, RFA and TACE) for liver metastases were enrolled in this retrospective cohort study. Patients were divided into Group A (46, hepatectomy) and Group B (73, either or both RFA and TACE). Propensity score matching analysis was employed.ResultsThe propensity model revealed that hepatectomy was associated with significantly longer OS compared with either or both RFA and TACE (P=0.021). The 1-, 3- and 5-year OS rates were 80.5%, 41.5% and 24.4%, respectively in Group A; and 85.4%, 21.9% and 12.2%, respectively in Group B. Subgroup analyses indicated that hepatectomy was associated with significantly longer long-term survival compared with TACE (P=0.033) and RFA (P=0.010). TACE had a similar efficacy as RFA (P=0.518), but with significantly lower costs (P=0.014) in for patients with metachronous GCLM.ConclusionHepatectomy is the optimal local treatment for GCLM when surgical R0 resection is intended. TACE attained a similar prognosis as RFA with relatively high cost-effectiveness, particularly for patients with metachronous GCLM.

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Section: Discussionmentioning

confidence: 99%

Evaluation of hepatectomy and palliative local treatments for gastric cancer patients with liver metastases: a propensity score matching analysis

Zhang

Gao

et al. 2017

Oncotarget

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“…Type II Preoperative systemic treatments should be administered to patients who are in good performance status to ensure that surgery can take place as soon as possible. Additionally, local treatments for liver metastases such as transcatheter arterial chemoembolization (TACE) 5,42,[75][76][77] and hepatic artery infusion chemotherapy (HAIC) [78][79][80] are recommended, as they can deliver high-concentration drugs to metastatic lesions as well as reduce the overall toxicity. TACE and HAIC can be used preoperatively or postoperatively.…”

Section: Recommendation Level: Highmentioning

confidence: 99%

Chinese consensus on the diagnosis and treatment of gastric cancer with liver metastases

Zhang

Chen

2020

Ther Adv Med Oncol

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Background: The incidence of gastric cancer with liver metastases (GCLM) is 9.9–18.7%, with a median survival time of 11 months and a 5-year survival rate <20%. Multidisciplinary treatment (MDT) is gradually gaining recognition as the most important method. However, specific treatment plans remain unclear. The aim of study was to provide a consensus to improve the diagnosis and treatment of GCLM. Methods: We brought together experts from relevant medical fields across China, including the Chinese Research Hospital Association Digestive Tumor Committee, Chinese Association of Upper Gastrointestinal Surgeons, Chinese Gastric Cancer Association, and the Gastrointestinal Surgical Group of Chinese Surgical Society Affiliated to Chinese Medical Association, to discuss and formulate this consensus. Results: A consensus was reached on the diagnosis and treatment of GCLM. Moreover, we have developed a new clinical classification system, the Chinese Type for Gastric Cancer Liver Metastases, based on the likelihood of a surgical treatment being successful. Conclusions: The MDT mode should be implemented throughout all treatment of GCLM. A Chinese version of this expert consensus has been published in the Chinese Journal of Practical Surgery (Volume 39, Issue 10, p. 405-411). Written permission was obtained from the Chinese Journal of Practical Surgery to disseminate the expert consensus in English.

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The aptamers generated from HepG2 cells

et al. 2017

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The Effect of Locoregional Transarterial Infusion Chemotherapy on Liver Metastasis after Gastric Cancer Resection

Cited by 5 publications

References 25 publications

Evaluation of hepatectomy and palliative local treatments for gastric cancer patients with liver metastases: a propensity score matching analysis

Evaluation of hepatectomy and palliative local treatments for gastric cancer patients with liver metastases: a propensity score matching analysis

Chinese consensus on the diagnosis and treatment of gastric cancer with liver metastases

The aptamers generated from HepG2 cells

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