1982
DOI: 10.1097/00003086-198205000-00044
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The Effect of Long-Term Low-Dose Diphosphonate Treatment on Rat Bone

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Cited by 29 publications
(8 citation statements)
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“…4). Similar findings have been noted in bones of diphosphonate-treated rats, which show decreased endosteal apposition but increased periosteal apposition [18]. This difference may be due to the factors controlling bone formation at different sites: At the endosteum formation follows resorption [30,31], whereas at the periosteum it is growth directed, and resorption is normally absent except at the metaphysis.…”
Section: Discussionsupporting
confidence: 78%
See 1 more Smart Citation
“…4). Similar findings have been noted in bones of diphosphonate-treated rats, which show decreased endosteal apposition but increased periosteal apposition [18]. This difference may be due to the factors controlling bone formation at different sites: At the endosteum formation follows resorption [30,31], whereas at the periosteum it is growth directed, and resorption is normally absent except at the metaphysis.…”
Section: Discussionsupporting
confidence: 78%
“…The methods employed have previously been reported in detail [18,19], and only a brief description will be given here. The sites examined are shown in Fig.…”
Section: Quantitative Bone Histologymentioning
confidence: 99%
“…In studies of bone growth, the number of Ocl nuclei has been Dichloromethylene diphosphonate (Cl 2 MDP) treatment results in an increase in the number and size of Ocl shown to reflect resorption velocities in various sites in the rabbit femur [24]. In the present study the hypocal- [31]. In the present study, no significant change in Ocl number was seen in Ga-treated rats.…”
Section: Discussionmentioning
confidence: 46%
“…6 The normal x-rays confirmed that the increased uptake in the bone scans was not caused by the presence of Paget's disease. 6 The normal x-rays confirmed that the increased uptake in the bone scans was not caused by the presence of Paget's disease.…”
Section: Commentmentioning
confidence: 61%