The effect of loteprednol suspension eye drops after corneal transplantation

Abstract

Background To compare the effect of loteprednol suspension eye drops after corneal transplantation with the effect of prednisolone acetate eye drops. Methods A total of 234 patients (234 eyes) who underwent penetrating keratoplasty (PKP) and lamellar keratoplasty (LKP) were retrospectively included. Patients who received 1 % prednisolone acetate eye drops were defined as 1 % prednisolone acetate eye drop group (n = 96), and patients who received 0.5 % loteprednol suspension eye drops were defined as 0.5 % loteprednol suspension eye drop group (n = 138). Results 35 cases in 1 % prednisolone acetate eye drops group and 27 cases in 0.5 % loteprednol suspension eye drops group developed corticosteroid-induced ocular hypertension, and were defined as prednisolone acetate group and loteprednol group. No significant differences were observed in the average intraocular pressure (IOP) at 1 week, 1 month, 3 months or 12 months postoperatively. There were significant differences in the average IOP between the two groups at 6 months postoperatively (P = 0.001). There were no significant differences in the average best corrected visual acuity (BCVA) at 1, 3 and 12 months postoperatively between two groups. The average 6-month postoperative BCVA was significantly higher in the prednisolone acetate group than the loteprednol group (P < 0.05). There were no significant differences in the postoperative graft rejection rates between the two groups (P > 0.05). Conclusions 0.5 % loteprednol suspension eye drops may be considered for long-term use after corneal transplantation.

Profilaktyka zakażeń po operacji zaćmy: fluorochinolony i leki przeciwzapalne – pojedynczo czy w preparatach złożonych?

“…At month 6 postoperatively, intraocular pressure was significantly higher in the group receiving prednisolone than in the group receiving loteprednol. Moreover, there were no significant differences between the postoperative graft rejection in the two study groups [4].…”

“…Therefore, authors recommended that future studies should be designed in a uniform and consistent manner. Chen et al [4] compared the efficacy and safety of 1% prednisolone acetate eye drops (n = 96) with 0.5% loteprednol suspension eye drops (n = 138) administered to corneal transplant patients. Thirty-five patients receiving prednisolone acetate eye drops and 27 treated with loteprednol developed corticosteroid-induced ocular hypertension.…”

“…Loteprednol etabonate exhibits greater potency than dexamethasone phosphate and a 4.3-fold higher GCR-binding affinity [3]. The anti-inflammatory efficacy and safety of loteprednol was confirmed in 2021 by Chen et al [4] who compared the effect of 0.5% loteprednol suspension eye drops with the effect of 1% prednisolone eye drops in patients after corneal transplantation. Authors reported no differences between the groups in terms of the number of graft rejections, but at 6 months postoperatively, intraocular pressure was significantly higher in the group receiving prednisolone acetate than in the group receiving loteprednol.…”