The effect of low-level laser therapy on oxidative stress and functional fitness in aged rats subjected to swimming: an aerobic exercise

Guaraldo, Simone A.; Serra, Andrey Jorge; Amadio, Eliane Martins; Antonio, Ednei L; Silva, Flávio Alves da; Portes, Leslie Andrews; Tucci, Paulo José Ferreira; Leal-Junior, Ernesto César Pinto; Carvalho, Paulo de Tarso Camillo de

doi:10.1007/s10103-016-1882-2

Cited by 32 publications

(24 citation statements)

References 27 publications

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“…The antioxidant system includes a number of antioxidant enzymes such as catalase (CAT) and superoxide dismutase (SOD), nonenzymatic antioxidants such as glutathione (GSH) and dietary antioxidants. As reported previously, aged rats suffered from decreased antioxidant capacity, as compared with young rats [9]. As antioxidants play a crucial role against ROS, an impaired antioxidant system aggravates the process of aging and may become another “vicious cycle”.…”

Section: Introductionmentioning

confidence: 54%

The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways

et al. 2017

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Age-related dysfunction of the central auditory system, known as central presbycusis, is characterized by defects in speech perception and sound localization. It is important to determine the pathogenesis of central presbycusis in order to explore a feasible and effective intervention method. Recent work has provided fascinating insight into the beneficial function of H2S on oxidative stress and stress-related disease. In this study, we investigated the pathogenesis of central presbycusis and tried to explore the mechanism of H2S action on different aspects of aging by utilizing a mimetic aging rat and senescent cellular model. Our results indicate that NaHS decreased oxidative stress and apoptosis levels in an aging model via CaMKKβ and PI3K/AKT signaling pathways. Moreover, we found that NaHS restored the decreased activity of antioxidants such as GSH, SOD and CAT in the aging model in vivo and in vitro by regulating CaMKKβ and PI3K/AKT. Mitochondria function was preserved by NaHS, as indicated by the following: DNA POLG and OGG-1, the base excision repair enzymes in mitochondrial, were upregulated; OXPHOS activity was downregulated; mitochondrial membrane potential was restored; ATP production was increased; and mtDNA damage, indicated by the common deletion (CD), declined. These effects were also achieved by activating CaMKKβ/AMPK and PI3K/AKT signaling pathways. Lastly, protein homeostasis, indicated by HSP90 alpha, was strengthened by NaHS via CaMKKβ and PI3K/AKT. Our findings demonstrate that the ability to resist oxidative stress and mitochondria function are both decreased as aging developed; however, NaHS, a novel free radical scavenger and mitochondrial protective agent, precludes the process of oxidative damage by activating CaMKKβ and PI3K/AKT. This study might provide a therapeutic target for aging and age-related disease.

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Section: Introductionmentioning

confidence: 54%

The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways

et al. 2017

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“…In the present study, we investigated the structure and the activity of glycated catalase exposed to laser irradiation. Laser irradiation such as LLLI is a convenient and attractive candidate for complement therapy, in order to reduce oxidative stress and to modify the activity of enzyme 39,40 even in diabetes condition. 24,27 In one study, the influence of low-level GaAlAs laser irradiation at 904 nm for different doses on amylase activity was investigated experimentally.…”

Section: Figurementioning

confidence: 99%

Effect of Low-Level Laser Irradiation on the Function of Glycated Catalase

et al. 2018

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Introduction: The aim of this work is to evaluate the effect of low-level laser irradiation (LLLI), by lasers with different wavelengths, on glycated catalase enzyme in vitro experimentally. Methods: This is done by measuring the activity and structure properties of glycated catalase enzyme. The structure properties were evaluated with circular dichroism (CD) and fluoroscopy methods. Three continuous wave (CW) lasers in the visible spectrum (λ = 450, 530, 638 nm) and a 100-ns pulsed laser in the infrared spectrum (λ = 905 nm) were chosen for comparison. For the infrared laser, same effects have been investigated for different energy doses. The effect of photon energy (hυ) at different wavelengths was measured on activity, CD, and fluoroscopy properties of catalase, and compared with the control group (samples without irradiation). The energy intensity of laser should not exceed 0.1 J/cm 2 . Experiments were performed on glycated catalase between 2 to 16 weeks after glycation of catalase. The LLLI effect was also investigated on the samples, by comparing the catalase activity, CD and fluoroscopy for different wavelengths. Results: Our results indicated, the decrease in catalase activity as a function of glycation time (weeks) for all samples, and a slight increase on its activity by different laser wavelengths irradiation for any fixed period of glycation time. Finally, the catalase activity has been increased as the laser's photon energy (hυ) intensified. More specifically, the blue laser (λ = 450 nm) had the most and the red laser (λ = 638 nm) had the least effect, and the green laser (λ = 530 nm) had the medium effect on catalase activity as well. Furthermore, pulsed laser had an additional effect by increasing energy dosage. Conclusion: As we expected in all experiments, an increase in the catalase activity was coincident with a decrease in the catalase fluoroscopy and CD parameters.

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“…The oxidative stress has been reported to be involved in several diseases such as diabetes mellitus, neurodegenerative disorders (Parkinson's disease (PD), Alzheimer's disease (AD), and multiple sclerosis (MS)), cardiovascular diseases (atherosclerosis and hypertension), respiratory diseases (asthma), cataract development, and rheumatoid arthritis [ 4 ]. Many studies showed an increase ROS and oxidative damage markers in blood and tissues of humans and animals during and after muscle damage [ 1 , 2 , 5 , 6 ]. After muscle injury, oxidative stress could be increased due to a number of potential sites for the ROS generation within the traumatized muscle.…”

Section: Introductionmentioning

confidence: 99%

“…There are studies showing that PBMT can improve mitochondrial function and mitigate ROS as well as reactive nitrogen species (RNS) generated during exercise training [ 12 ]. Thus, PBMT has been reported to modulate oxidative events, reducing oxidative stress in different situations [ 5 , 13 – 15 ]. We performed this systematic review to identify animal research defining the effects of PBMT on experimental models of muscle injury and the impact of PBMT dosage.…”

Section: Introductionmentioning

confidence: 99%

Effects of Photobiomodulation Therapy on Oxidative Stress in Muscle Injury Animal Models: A Systematic Review

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Serra

Stancker

et al. 2017

Oxidative Medicine and Cellular Longevity

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This systematic review was performed to identify the role of photobiomodulation therapy on experimental muscle injury models linked to induce oxidative stress. EMBASE, PubMed, and CINAHL were searched for studies published from January 2006 to January 2016 in the areas of laser and oxidative stress. Any animal model using photobiomodulation therapy to modulate oxidative stress was included in analysis. Eight studies were selected from 68 original articles targeted on laser irradiation and oxidative stress. Articles were critically assessed by two independent raters with a structured tool for rating the research quality. Although the small number of studies limits conclusions, the current literature indicates that photobiomodulation therapy can be an effective short-term approach to reduce oxidative stress markers (e.g., thiobarbituric acid-reactive) and to increase antioxidant substances (e.g., catalase, glutathione peroxidase, and superoxide dismutase). However, there is a nonuniformity in the terminology used to describe the parameters and dose for low-level laser treatment.

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The effect of low-level laser therapy on oxidative stress and functional fitness in aged rats subjected to swimming: an aerobic exercise

Cited by 32 publications

References 27 publications

The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways

The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways

Effect of Low-Level Laser Irradiation on the Function of Glycated Catalase

Effects of Photobiomodulation Therapy on Oxidative Stress in Muscle Injury Animal Models: A Systematic Review

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