The Effect of &lt;i&gt;Citrullus colocynthis&lt;/i&gt; Pulp Extract on the Liver of Diabetic Rats a Light and Scanning Electron Microscopic Study

Khalil, M. W.; Mohamed, Gamal A.; Dallak, Mohammad; Al‐Hashem, Fahaid; Sakr, Hussein F.; Eid, Refaat A.; Adly, Mohamed A.; Alkhateeb, Mahmoud; Banihani, Saleh M.; Hassan, Zuhair M.; Bashir, Nabil

doi:10.3844/ajbbsp.2010.155.163

Cited by 21 publications

(13 citation statements)

References 28 publications

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“…Similarly to Khalil et al (27), our histological analysis of liver tissue in the control mice with alloxaninduced diabetes shows more or less vacuolated liver cells (Figure 2a,2b), a probable consequence of fat metabolism disorders. In half of the samples, the liver cells are more vacuolated around the central veins than around Kiernan's spaces (Figure 2a).…”

Section: Resultssupporting

confidence: 84%

Naringenin ameliorates pathological changes in liver and kidney of diabetic mice: a preliminary study / Naringenin reducira histopatološke promjene u jetri i bubregu miševa s dijabetesom

Sirovina

Oršolić

Gregorović

et al. 2016

Archives of Industrial Hygiene and Toxicology

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The effect of naringenin, a flavonoid found in grapefruit, orange, and tomato, on lipid peroxidation and histopathological changes in the liver and kidneys of alloxan-induced diabetic mice were investigated. Two days after alloxan injection (75 mg kg -1 , i.v.), naringenin ethanolic solution (0.5 % v/v) was given to mice intraperitoneally (50 mg kg -1 per day) for seven days. Naringenin's impact on lipid peroxidation was measured by the 2-thiobarbituric acid test and histopathological changes were examined under a light microscope. Naringenin administration resulted in a significant decrease of lipid peroxidation level in liver and kidney tissue, as well as in a decreased number of vacuolated liver cells and degree of vacuolisation. Indications of tissue repair in kidney suggested that amelioration of diabetes-induced renal damage could be achieved over a longer period of time. Findings suggest that naringenin could be considered a dietary supplement in the prevention or treatment of diabetic complications and other diseases connected wih oxidative stress, and gives a hope that it could show similar effects in the treatment of diabetes in humans.

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Section: Resultssupporting

confidence: 84%

Naringenin ameliorates pathological changes in liver and kidney of diabetic mice: a preliminary study / Naringenin reducira histopatološke promjene u jetri i bubregu miševa s dijabetesom

Sirovina

Oršolić

Gregorović

et al. 2016

Archives of Industrial Hygiene and Toxicology

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“…It participates in the uptake, oxidation, and metabolic conversion of free fatty acids and in the synthesis of cholesterol, phospholipids, and triglycerides [1].…”

Section: Introductionmentioning

confidence: 99%

The histopathological and biochemical effects of green tea extract on the liver of high-fat diet and streptozotocin diabetic female rats

El-Mahalaway¹,

El-Gohary

Wahba

2013

Evidence Based Womenʼs Health Journal

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ObjectiveTo evaluate the histopathological and biochemical effects of green tea extract on the liver tissues of high-fat diet and streptozotocin diabetic female rats. Methods Eighty adult female rats weighing 150-200 g were taken for the study and divided into four groups: group I (control nondiabetic group), group II (high-fat diet and nondiabetic), group III (high-fat diet and diabetic), and group IV (high-fat diet and diabetic, treated with green tea extract with a concentration of 1.5% in drinking water for 4 weeks), with each group comprising 20 rats (n = 20). Non-insulin-dependent diabetes was induced by a combination of high-fat diet and single intraperitoneal injection of streptozotocin (25 mg/kg body weight). Biochemical estimation of fasting blood glucose, fasting insulin (FINS), homeostasis model assessment of insulin resistance (HOMA-IR) index, and plasma alanine transaminase was carried out. The livers of the rats were collected for examination of clinical biochemistry, which includes measuring levels of tissue malondialdehyde (MDA) and reduced gluthione (GSH), and were studied histopathologically by light and electron microscopy. ResultsBody weight, FINS, and the HOMA-IR index were increased in the high-fat diet and nondiabetic group. Body weight, fasting blood glucose, FINS, and the HOMA-IR index were increased in the high-fat diet and diabetic group, but were significantly reduced in the high-fat diet and diabetic group treated with green tea extract. The level of MDA was significantly increased, whereas the level of GSH was significantly decreased in the liver of high-fat diet and diabetic rats; however, the level of MDA was significantly decreased, whereas the level of GSH was significantly increased in the liver of the high-fat diet and diabetic rats treated with green tea extract. Liver histopathology of non-insulin-dependent diabetes rats showed pathological changes. However, treatment with green tea extract attenuated the histopathological changes and corrected the biochemical parameters mentioned above. ConclusionGreen tea extract could potentially attenuate the hepatic injury induced by high-fat diet and streptozotocin as it has the capacity to scavenge free radicals, protect against oxidative stress, improve antioxidant enzyme activities, and exert an antidiabetic effect.

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“…Scanning electron microscope examination of these livers revealed numerous lipid droplets within hepatocytes, damaged blood sinusoids and hemorrhage of erythrocytes between hepatocytes and inside Disse's spaces. The liver of Citrullus colocynthis-treated rats revealed minor histological changes versus the control animals [49].…”

Section: Citrullus Colocynthismentioning

confidence: 99%

Medicinal plants with antidiabetic effects (part 2): plant based review

Al-Snafi¹

2016

IOSRPHR

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The Effect of <i>Citrullus colocynthis</i> Pulp Extract on the Liver of Diabetic Rats a Light and Scanning Electron Microscopic Study

Cited by 21 publications

References 28 publications

Naringenin ameliorates pathological changes in liver and kidney of diabetic mice: a preliminary study / Naringenin reducira histopatološke promjene u jetri i bubregu miševa s dijabetesom

Naringenin ameliorates pathological changes in liver and kidney of diabetic mice: a preliminary study / Naringenin reducira histopatološke promjene u jetri i bubregu miševa s dijabetesom

The histopathological and biochemical effects of green tea extract on the liver of high-fat diet and streptozotocin diabetic female rats

Medicinal plants with antidiabetic effects (part 2): plant based review

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