The effect of luteolin-7-O-β-d-glucuronopyranoside on gastritis and esophagitis in rats

Abstract

This study evaluated the inhibitory action of luteolin-7-O-beta-D-glucuronopyranoside, luteolin which was isolated from Salix gilgiana leaves, and omeprazole on reflux esophagitis and gastritis in rats. Reflux esophagitis and gastritis were induced surgically and by the administration of indomethacin, respectively. The intraduodenal administration of luteolin-7-O-beta-D-glucuronopyranoside decreased the ulcer index, injury area, gastric volume and acid output, and increased the gastric pH compared with luteolin. Luteolin-7-O-beta-D-glucuronopyranoside significantly decreased the size of the gastric lesions that had been induced by exposing the gastric mucosa to indomethacin. The malondialdehyde content, which is the end product of lipid peroxidation, was increased significantly after inducing of reflux esophagitis. The malondialdehyde content was decreased by Luteolin-7-O-beta-D-glucuronopyranoside but not luteolin or omeprazole. Luteolin-7-O-beta-D-glucuronopyranoside has a more potent antioxidative effect than luteolin. Luteolin-7-O-beta-D-glucuronopyranoside is a promising drug for the treatment of reflux esophagitis and gastritis.

Gastroprotective effect of Cymbopogon citratus infusion on acute ethanol-induced gastric lesions in rats

“…It is well known that many flavonoids have antisecretory and cytoprotective properties in different experimental models of gastric ulcer (Casa et al, 2000;Mota et al, 2009). In particular, several plants with anti-ulcer activity which contain luteolin and luteolin O-and C-glycosides have been reported (Batista et al, 2004;Coelho et al, 2009Coelho et al, , 2006Min et al, 2006;Yesilada et al, 2000). Therefore, the polyphenolic chemical composition of the extract may contribute, at least in part, to the gastroprotective effects observed in this study.…”

Anti-Oxidative and Anti-Inflammatory Effects of QGC in Cultured Feline Esophageal Epithelial Cells

“…Administration of anti-oxidants could attenuate the severity of experimentally induced reflux esophagitis [36] and prevent or treat reflux esophagitis [37]. Flavonoids are reported as free radical scavengers and cytoprotective compound [7,21].…”

Gastroprotective Effect of the Three Glucuronopyranoside Flavonoids in Rats

“…Six hours after pylorus ligation, rats were sacrificed by cervical dislocation and the esophagus clamped, as previously confirmed reflex esophagitis [ 15 ]. Samples of gastric juice were collected in graduated conical centrifuge tubes and centrifuged at 3,000 g for 10 min at 4℃.…”

“…In the current our study the involvement of extensive lipid peroxidation in ethanol-induced gastric damage was evidenced by the accumulation of MDA level, as an index of lipid peroxidation, and MPO activity, as a marker of neutrophil aggregation [ 14 ]. It has been demonstrated that free radical damage to the gastric or esophageal mucosa can be prevented by the administration of free radical scavengers [ 15 ].…”