The effect of macrogol administration on the quality of macroscopic images and transit time in canine capsule endoscopy

Rychlik, Andrzej; Nowicki, Marcin; Kander, M.; Szweda, M.

doi:10.2478/pjvs-2014-0098

Cited by 6 publications

(13 citation statements)

References 10 publications

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“…Indeed, the GET and SITT of the 2 control animals were also markedly disparate and overlapped with those observed in the clinical cases. Similarly, values were comparable to those obtained from 36 clinically healthy 6-to 7-month-old research beagles infected with various intestinal nematodes (mean GET 1.94 h, sd 1.40 h; SITT 1.15 h, sd 1.01 h; A. C. Y. Lee, unpublished data) and those published in a recent study on healthy dogs 20 to 26 kg (Rychlik et al . 2014 ).…”

Section: Discussionsupporting

confidence: 88%

“…Similarly, values were comparable to those obtained from 36 clinically healthy 6‐ to 7‐month‐old research beagles infected with various intestinal nematodes (mean GET 1.94 h, sd 1.40 h; SITT 1.15 h, sd 1.01 h; A. C. Y. Lee, unpublished data) and those published in a recent study on healthy dogs 20 to 26 kg (Rychlik et al . ). Finally, several patients had varying degrees of systemic illness (such as DIC, systemic lupus erythematosus, immune‐mediated thrombocytopenia), and the effect of these diseases on GI transit time is uncertain, particularly as studies in humans have shown increased transit times in critically ill trauma patients (Rauch et al .…”

Section: Discussionmentioning

confidence: 97%

“…macrogol) could have improved image quality in these clinical cases as has been reported previously (Rychlik et al . ). Further study is needed to clarify the effect of fasting time and GI preparation on image acquisition.…”

Section: Discussionmentioning

confidence: 97%

“…Moreover, studies have shown that capsules designed for evaluation of the small bowel in humans have limited utility in the evaluation of large bowel lesions in dogs, even when colonoscopy preparation protocols are utilised (Rychlik et al . ).…”

Section: Discussionmentioning

confidence: 97%

“…This may have contributed to a lower rate of complete examination in our study (5 of 8 dogs=63%) compared to the 100% observed in healthy client‐owned dogs (Rychlik et al . ) and 83% in parasitised research beagles (Lee et al . ).…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of capsule endoscopy to detect mucosal lesions associated with gastrointestinal bleeding in dogs

Davignon

Lee

Johnston

et al. 2016

J of Small Animal Practice

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OBJECTIVE The objective of this study was to examine the utility of capsule endoscopy to detect mucosal abnormalities in dogs with gastrointestinal haemorrhage. METHODS Capsules were administered to 2 healthy controls and 8 patients with gastrointestinal haemorrhage. Images were evaluated for quality, gastric emptying time, small intestinal transit time and presence of lesions. RESULTS There were no adverse effects of capsule endoscopy in dogs weighing from 7·7 to 58 kg. The capsule traversed the entire gastrointestinal tract in 5 of 8 patients, with high quality images obtained in the stomach and small intestine. Gastric emptying time and small intestinal transit time ranged from 1 to 270 and 15 to 180 minutes, respectively. In 3 of 8 patients, the capsule remained in the stomach despite pro‐kinetics. Gastric lesions included mild haemorrhage and pinpoint erosion (4 of 8), a mass (1) and thickened bleeding pyloric mucosa (2). Two of 3 dogs with capsule retention had gastric lesions. Intestinal lesions included a healing duodenal ulcer, abnormal villi, ileal ulceration and colonic bleeding. Lesions identified by capsule endoscopy were considered a significant source of haemorrhage in 4 of 7 dogs with active bleeding. The relevance of pinpoint gastric mucosal erosions to blood loss is unclear. CLINICAL SIGNIFICANCE Capsule endoscopy can enable the non‐invasive detection of gastric and small intestinal mucosal lesions in dogs presenting for evaluation of gastrointestinal bleeding.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

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Evaluation of capsule endoscopy to detect mucosal lesions associated with gastrointestinal bleeding in dogs

Davignon

Lee

Johnston

et al. 2016

J of Small Animal Practice

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A wireless endoscopy capsule suitable for imaging of the equine stomach and small intestine

Steinmann

Bezugley²,

Bond

et al. 2020

Veterinary Internal Medicne

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Background Capsule endoscopy offers a new method for visualization of the gastrointestinal mucosa in horses where other imaging technologies have diagnostic limitations. Objectives To (1) test the feasibility of using this novel endoscopy capsule to visualize intestinal mucosa in horses, including an objective assessment of image quality, (2) assess how changes in preadministration preparation affect the transit time and the amount of gastrointestinal mucosa visualized, and (3) describe intestinal mucosa lesions in healthy horses. Animals Five healthy adult horses. Methods Three protocols were used in a crossover study design. Protocols varied in time fasted, amount of oral fluid administered, and exercise. Manure was radiographically inspected for capsule recovery. Percentage of visible gastrointestinal mucosa was objectively assessed. Results Detailed images of the gastrointestinal mucosa were recorded with all 3 protocols, including images of the pylorus, major duodenal papilla, individual villi, and ileocecal junction. Visualization of large intestinal mucosa was poor. Interobserver agreement on image quality was excellent. Capsule administration after feed withholding for 24 hours provided the greatest percentage of visible mucosa in the stomach and small intestine. Total transit time to capsule excretion was 6.5 (3‐8.75) days. Of 15 capsules administered, 3 were not recovered. Lesions visualized included mucosal erosion, ulceration and hemorrhage, areas of thickened mucosa, and evidence of parasitism. Conclusions This novel endoscopic capsule appears safe, practical, and noninvasive in horses; however, variability in capsule excretion time must be taken into account for clinical application.

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Prevalence of gastrointestinal lesions in dogs chronically treated with nonsteroidal anti‐inflammatory drugs

Mabry

Hill

Tolbert

2021

Veterinary Internal Medicne

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Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most common pharmaceutical associated with gastroduodenal ulceration and perforation. The prevalence of gastrointestinal (GI) injury associated with chronic use of NSAIDs in dogs is unknown. Objective/Hypothesis: To determine the prevalence of GI mucosal erosions in dogs receiving chronic treatment with NSAIDs. We hypothesized that dogs receiving NSAIDs would have more GI mucosal erosions and longer GI transit time than a control population. Animals: Fourteen client-owned medium-and large-breed dogs receiving an NSAID for at least 30 days and 11 client-owned control dogs undergoing video capsule endoscopy (VCE) for evaluation of chronic GI disease. Methods: Dogs were prospectively recruited after determining no clinically relevant comorbidities were present and VCE was performed. The GI transit time and the presence of mucosal lesions were recorded. Results: Twelve dogs receiving NSAIDs and 11 retrospectively evaluated control dogs were included. The NSAIDs administered included carprofen (9 dogs), meloxicam (2 dogs), and firocoxib (1 dog) for a median of 6 months. Ten (83.3%; 95% confidence interval; 51.6%-97.9%) NSAID-treated dogs had GI erosions. Erosions were seen with all 3 NSAIDs in at least 1 dog. Three of 11 control dogs had gastric erosions. Dogs receiving NSAIDs had more erosions detected (P = .004). Conclusions and Clinical Relevance: Subclinical GI erosions are more common in dogs receiving chronic treatment with NSAIDs than in control dogs with chronic GI disease, suggesting that NSAIDs be used with caution, particularly in dogs with comorbidities predisposing them to GI ulceration.

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The effect of macrogol administration on the quality of macroscopic images and transit time in canine capsule endoscopy

Cited by 6 publications

References 10 publications

Evaluation of capsule endoscopy to detect mucosal lesions associated with gastrointestinal bleeding in dogs

Evaluation of capsule endoscopy to detect mucosal lesions associated with gastrointestinal bleeding in dogs

A wireless endoscopy capsule suitable for imaging of the equine stomach and small intestine

Prevalence of gastrointestinal lesions in dogs chronically treated with nonsteroidal anti‐inflammatory drugs

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